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Pioneering gene therapy for rare immune disorder shows promise in early pre-clinical studies

The development of a pioneering gene therapy to treat a devastating, rare immune disorder led by UCL scientists is set to move into its next phase following promising early pre-clinical studies.

27 Jun 2026

Gene fusion patterns refine classification of rare acute leukemias

Acute leukemias with chimeric fusion genes involving FET (FUS, EWSR1, and TAF15) family proteins and ETS (E26 transformation-specific)-like transcription factors often present with unique clinical and pathological characteristics.

27 Jun 2026

Scientists uncover immune mechanisms driving rare gastrointestinal disorder

A collaborative team led by Dr. Jingnan Li and Dr. Ji Li at Peking Union Medical College Hospital, together with Associate Professor Xiaohuan Guo at Tsinghua University and Academician Ye-Guang Chen at Tsinghua University School of Life Sciences, published a study in Volume 2, article number 28 of the journal Immunity & Inflammation on June 17, 2026.

26 Jun 2026

New screening approach identifies proteins that control human gene expression

Researchers at University of California San Diego have developed a large-scale screening approach that identifies proteins controlling a fundamental step in gene expression known as alternative polyadenylation (APA).

26 Jun 2026

Case report details rare basal cell carcinoma on patient's finger

Basal cell carcinoma is the most prevalent form of skin cancer, typically developing on sun-exposed areas like the face and neck.

26 Jun 2026

Engineered CAR T cells successfully target bladder cancer in mice

Researchers at Weill Cornell Medicine, Cedars-Sinai Medical Center, and Roswell Park Comprehensive Cancer Center have developed genetically engineered CAR T cells that specifically target and kill bladder cancer cells.

26 Jun 2026

New accessible multiplex imaging workflow advances spatial liver research

Spatial biology technologies are reshaping modern biomedical research by enabling the visualization of cellular organization and interactions within intact tissues.

26 Jun 2026

Scientists identify key osteoblast protein that promotes bone formation

New study identifies CAR3 as a key osteoblast protein promoting collagen mineralization, bone formation, and skeletal regeneration.

26 Jun 2026

Biognosys showcases next-gen multiomics innovations at ASMS 2026

The Biognosys Group, a leader in mass spectrometry-based multiomics, announces advancements across its integrated multiomics portfolio, highlighting next-generation software, sample preparation, enrichment, and separation technologies for proteomics and metabolomics.

From Biognosys 26 Jun 2026

AI and multiomics reveal how gut bacteria trigger colon cancer

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

26 Jun 2026

Targeting specific immune pathways could prevent severe reperfusion injury

IRI is a shared pathological process in myocardial infarction, ischaemic stroke, acute kidney injury, lung injury, and graft dysfunction after transplantation.

26 Jun 2026

Smart nanoplatform uses wound acidity to trigger accelerated healing

Infected wounds pose a significant medical challenge, often leading to delayed healing and complications due to bacterial biofilms and excessive inflammation.

26 Jun 2026

Study uncovers self-propelled actin filaments that shape living cells

Every time a white blood cell engulfs a bacterium, a neuron extends a projection to connect with a neighboring cell, or when a cancer cell forcefully squeezes through tissue to spread, the cell must change its shape to accommodate the movement.

26 Jun 2026

Scientists find link between bacterium in the gut ecosystem and lupus

Scientists at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, found a link between a bacterium in the gut microbiome, or ecosystem, and lupus, which could lead to more effective treatment of the disease, in a study published in Nature Communications.

25 Jun 2026

Lipid nanoparticles enhance immune response against lung cancer

Researchers at the University of Arizona R. Ken Coit College of Pharmacy have developed a new strategy that helps the immune system recognize and attack lung cancer tumors more effectively.

25 Jun 2026

Protein-sharing helps dormant bacteria withstand antibiotic treatment

When bacteria are under antibiotic attack, it is not 'every man for himself.' Researchers at Baylor College of Medicine and colleagues from collaborating institutions have discovered that bacterial populations work as a team to survive antibiotics.

25 Jun 2026

Natural compound puerarin may protect against cholestatic liver fibrosis

A recent study published in Current Molecular Pharmacology demonstrates that puerarin-a bioactive isoflavone derived from Kudzu root and widely used in traditional Chinese medicine-may offer significant therapeutic benefits against cholestatic liver fibrosis, a progressive pathological condition arising from impaired bile formation and flow that currently lacks effective pharmacotherapies.

25 Jun 2026

Iron overload gradually increases neurons' vulnerability to neurodegeneration

Neurodegenerative diseases affect tens of millions of people worldwide. Among these, Alzheimer's and Parkinson's diseases are the most common; in the United States alone, the Alzheimer's Disease Association and Parkinson's Foundation report roughly 7 million people with Alzheimer's and another million with Parkinson's.

25 Jun 2026

Opposing protein pathways control skin regeneration and disease development

Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine researchers have found.

25 Jun 2026

Lactate and lactylation play multifaceted roles in pancreatic ductal adenocarcinoma

A comprehensive review recently published in Current Molecular Pharmacology illuminates the pivotal, multifaceted roles of lactate and its downstream protein modification, lactylation, in pancreatic ductal adenocarcinoma (PDAC).

25 Jun 2026