Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

When genomic sequencing fails to diagnose a rare disease

Routine sequencing has given unprecedented insight into the genetics of rare diseases, but genomics fails to diagnose up to half of patients who are tested. That's the problem German scientists tackled in a recent study in the journal Molecular & Cellular Proteomics.

11 Feb 2019

New measurable indicator could prove instrumental in fight against HIV

George Mason University's Yuntao Wu is the lead scientist on a research team that has identified a measurable indicator that could prove instrumental in the fight against HIV.

11 Feb 2019

FDA grants clearance to Hologic’s assay for detection of common sexually transmitted infections

Hologic, Inc. announced today that the U.S. Food and Drug Administration (FDA) has granted clearance for its Aptima Mycoplasma genitalium assay, the first and only FDA-cleared test to detect this under-recognized but increasingly common sexually transmitted infection (STI).

23 Jan 2019

Scientists solve mystery of Yemen cholera epidemic

The most likely source of the cholera epidemic in Yemen has been discovered by scientists. Through the use of genomic sequencing, scientists at the Wellcome Sanger Institute and Institut Pasteur estimate the strain of cholera causing the current outbreak in Yemen - the worst cholera outbreak in recorded history - came from Eastern Africa and entered Yemen with the migration of people in and out of the region.

2 Jan 2019

Study: Reactivation of HIV-infected cells depends on its size and cell cycle

Thanks to the development of antiretroviral drugs, human immunodeficiency virus is considered a manageable chronic disease today.

27 Dec 2018

Experimental HIV vaccine strategy works in non-human primates, research shows

For more than 20 years, scientists at Scripps Research have chipped away at the challenges of designing an HIV vaccine. Now new research, published in Immunity, shows that their experimental vaccine strategy works in non-human primates.

14 Dec 2018

MUHC's 'Dr. House' discovers new genetic disease and the gene responsible for it

A team from the Research Institute of the McGill University Health Centre led by Dr. Donald Vinh, the RI's so-called "Dr. House" because of his research into rare diseases, has discovered a new human disease and the gene responsible for it, paving the way for the proper diagnosis of patients globally and the development of new therapies.

7 Dec 2018

Young black gay men are more likely to have HIV infection than their white peers

Young black men who have sex with men are 16 times more likely to have an HIV infection than their white peers despite more frequent testing for HIV and being less likely to have unsafe sex, reports a new Northwestern Medicine study.

5 Dec 2018

Researchers aim to develop a functional cure for HIV using therapeutic vaccines

EU-funded researchers are leading efforts to develop a functional cure for HIV using innovative therapeutic vaccines to halt the progression of the devastating virus, increase the availability and affordability of treatment, and improve patients' quality of life.

30 Nov 2018

ECDC and WHO release latest data on HIV epidemic in the European Region

The European Centre for Disease Prevention and Control and the WHO Regional Office for Europe release the latest data on the HIV epidemic in the European Region, marking the 30th anniversary of World AIDS Day.

29 Nov 2018

Study reveals direct link between stigma and cognitive performance in people with HIV

A new study has drawn a direct link between the amount of stigma men with HIV report experiencing and their scores on cognitive tests, measuring abilities such as memory and attention.

27 Nov 2018

Scientists develop new surgical process for studying the thymus

Elisa Oltra, head of the Genetic Exppression and Immunity group of the Faculty of Medicine at the Catholic University of Valencia, in collaboration with Alejandro Caicedo, professor of the Department of Medicine of the University of Miami, have developed a surgical process which makes it possible to place functional fragments of the thymus in the anterior chamber of the eyes of mice.

26 Nov 2018

Myriad biological, societal factors that impact CKD severity for children of African descent

Myriad biological and societal factors can impact the occurrence and accelerate progression of chronic kidney disease for children of African descent - including preterm birth, exposure to toxins during gestation and lower socioeconomic status - and can complicate these children's access to effective treatments, according to an invited commentary published in the November 2018 edition of American Journal of Kidney Diseases.

21 Nov 2018

Researchers discover key factors behind intestinal inflammation in CVID patients

Oregon State University researchers have discovered two key factors behind the intestinal inflammation that plagues people suffering from a disorder that affects their immune system.

14 Nov 2018

Getting right level of leptin may help protect cardiovascular health

Like that famous bowl of porridge, when leptin levels are "just right" they help protect our cardiovascular health, scientists say.

29 Oct 2018

X4 Pharmaceuticals announces clinical data of X4P-001-IO and Opdivo in patients with clear cell renal cell carcinoma

X4 Pharmaceuticals, a clinical stage biotechnology company developing novel CXCR4 antagonists to improve immune cell trafficking to treat cancer and rare disease, today announced results from a pilot study of X4P-001-IO in combination with Opdivo (nivolumab) in patients with clear cell renal cell carcinoma who are non-responsive to the anti-PD-1 checkpoint inhibitor Opdivo alone.

22 Oct 2018

Tobacco control must be highest priority in national cancer control plan, says report

The highest priority in a national cancer control plan must be expansion of tobacco control--the intervention with the largest potential health benefits--according to a new American Cancer Society report, the second in a series of articles that together inform priorities for a comprehensive cancer control plan.

11 Oct 2018

Scientists discover new molecular pathway that controls colorectal cancer development

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.

8 Oct 2018

Leadiant Biosciences announces FDA approval of Revcovi for treating pediatric, adult ADA-SCID patients

Leadiant Biosciences, Inc. today announced that the Food and Drug Administration has granted approval to Revcovi (elapegademase-lvlr) injection in the U.S. Revcovi is a new enzyme replacement therapy for the treatment of adenosine deaminase severe combined immune deficiency in pediatric and adult patients.

7 Oct 2018

Two-pronged approach represents potential strategy for targeting latent reservoir of HIV

With more than 35 million people worldwide living with the virus and nearly 2 million new cases each year, the human immunodeficiency virus remains a major global epidemic.

4 Oct 2018