Kinase News and Research

RSS

Oral deucravacitinib shows promise in patients with active lupus

Tyrosine kinases are enzymes that play central roles in signaling by cytokines involved in the pathogenesis of autoimmune diseases, including lupus.

14 Nov 2022

What is the role of macrophage origin, function, and heterogeneity in health and disease?

In a new study, researchers examined the wealth of information available regarding the heterogeneity of tissue macrophages.

14 Nov 2022

How mRNA vaccines work without an added adjuvant

In a recent study published in the Immunity journal, researchers explored the current knowledge of the mechanism employed by messenger ribonucleic acid (mRNA) vaccines to elicit innate immune activation.

13 Nov 2022

Updated EULAR recommendations on the use of DMARDs for people with RA

Since their first publication in 2010, the EULAR recommendations for the use of disease-modifying anti-rheumatic treatments (DMARDs) in people with RA have become a most important publication in the field, and their updates are relied upon by many healthcare professionals, professional organizations and other stakeholders to offer an up-to-date and robust analysis on an optimal approach to the application of available treatment options in clinical practice.

11 Nov 2022

A knowledgebase of currently known categorized COVID-19 severity variants

In a recent study posted to the medRxiv* preprint server, researchers assessed human genome variants related to the susceptibility and severity of coronavirus disease 2019 (COVID-19).

10 Nov 2022

Empty lipid nanoparticles trigger maturation and activation of antigen-presenting cells

In a recent study posted to the Research Square* preprint server and under review at the Nature Portfolio journal, researchers reported activation and maturation of antigen-presenting cells (APCs) by lipid nanoparticles (LNPs).

9 Nov 2022

Specific protein imbalance revealed in blood tests can help quantify preeclampsia risk

In a study of pregnant women in the United States, Cedars-Sinai investigators found that a specific imbalance of two placental proteins could predict which women were at risk of developing a severe form of preeclampsia, a life-threatening blood pressure disorder.

9 Nov 2022

Study: No significant difference in cancer risk in rheumatology patients with history of malignancy taking DMARDs

New research presented this week at ACR Convergence 2022, the American College of Rheumatology's annual meeting, found no significant difference in cancer risk in patients with rheumatic disease and a history of malignancy taking biologic or targeted synthetic DMARDs compared to those treated with TNF inhibitors.

8 Nov 2022

Viral whole genome study in the United States identifies ORF-disrupting mutations in monkeypox virus

Researchers used whole genome sequencing to evaluate monkeypox virus samples from Washington and Ohio states in the United States and identified 25 samples with open reading frame (ORF)-disrupting mutations.

7 Nov 2022

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Researchers identified a genetic association signal, via genome-wide association studies, between severe COVID-19 with systemic lupus erythematosus, an autoimmune disease.

7 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Study identifies a new therapeutic strategy to tackle endometrial cancer

Inhibition of the ERK5 protein kinase reduces the proliferation and survival of endometrial cancer cells, and potentiates standard chemotherapy.

2 Nov 2022

EULAR points-to-consider can guide diagnostic evaluation, treatment and monitoring of SAIDs

SAIDs are a group of multi-system disorders caused by dysfunction in the innate immune system. A number of these SAIDs are mediated by a cytokine called interleukin-1 (IL-1), including the cryopyrin-associated periodic syndromes (CAPS), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), and deficiency of the IL-1 receptor antagonist (DIRA).

1 Nov 2022

Kinase News and Research

Oral deucravacitinib shows promise in patients with active lupus

What is the role of macrophage origin, function, and heterogeneity in health and disease?

How mRNA vaccines work without an added adjuvant

Updated EULAR recommendations on the use of DMARDs for people with RA

A knowledgebase of currently known categorized COVID-19 severity variants

Empty lipid nanoparticles trigger maturation and activation of antigen-presenting cells

Specific protein imbalance revealed in blood tests can help quantify preeclampsia risk

Study: No significant difference in cancer risk in rheumatology patients with history of malignancy taking DMARDs

Viral whole genome study in the United States identifies ORF-disrupting mutations in monkeypox virus

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Fermented dairy products can improve gut mucosal immunity

Study identifies a new therapeutic strategy to tackle endometrial cancer

EULAR points-to-consider can guide diagnostic evaluation, treatment and monitoring of SAIDs

Protein kinase CK2 controls CD8+ T cell effector and memory functions during Listeria infection

Research opens up new avenues for overcoming treatment resistance in colorectal cancer

New discovery may change the textbook model of GPCR-mediated signaling

COVID-19 and the gut

Swine acute diarrhea syndrome coronavirus promotes replication by inducing autophagy

A review of emerging pediatric respiratory viruses

What are the health benefits and food industry applications of wine industry by-products?

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Applications Engineer

Latest News