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Study maps novel coronavirus infection in cells of nasal cavity, airway and lungs

In a major scientific study published in the journal Cell, scientists at the UNC School of Medicine and the UNC Gillings School of Global Public Health have characterized the specific ways in which SARS-CoV-2 – the coronavirus that causes COVID-19 – infects the nasal cavity to a great degree – replicating specific cell types – and infects and replicates progressively less well in cells lower down the respiratory tract, including the lungs.

1 Jun 2020

Expert offers COVID-19 guidance for patients with COPD

Chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema, is a chronic lung disease that makes it hard to breathe. The disease affects millions of Americans and is the fourth leading cause of disease-related death in the U.S. People with COPD have a higher risk of more severe illness from COVID-19 due to their existing lung problems.

30 May 2020

How comorbidities affect SARS-CoV-2 viral entry

Almost from the start of the current COVID-19 pandemic, it has become clear that individuals suffering from other medical conditions like diabetes, cardiovascular disease, and lung disease are far more likely to contract the infection and to have a poorer outcome.

28 May 2020

Study shows children and adults have a comparable expression of SARS-CoV-2 entry-related genes

A recent paper by researchers from China demonstrated comparable expression levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry mediators in adults and children, suggesting that previously implied difference in viral-entry associated genes is likely not responsible for milder symptoms in children. The study is currently available on the medRxiv preprint server.

27 May 2020

Zero benefit of Hydroxychloroquine or Chloroquine in COVID-19, says extensive study

The purported "game-changer" anti-malarial drug Hydroxychloroquine, which was claimed to be effective in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and also helping better outcomes in COVID-19 patients, seems to have failed in clinical trials.

25 May 2020

Children with COVID-19 presenting with sudden severe lung disease

Even as the COVID-19 pandemic continues to seek out new victims, puzzling new presentations are further confusing the situation. A new study published online in The Lancet Rheumatology in May 2020 reports a case of severe COVID-19 in a child who rapidly developed acute respiratory distress symptoms without prior respiratory symptoms. This case should alert clinicians to consider this diagnosis in children as well.

24 May 2020

Capillary leakage important in COVID-19 respiratory distress

Now, a new study published on the preprint server medRxiv reports the pivotal role played by protein leakage through lung capillaries and promotes the use of serum albumin as a biomarker of disease progression and severity.

24 May 2020

Smokers at increased risk of severe COVID-19 according to a large population study

A new UK study available on the preprint server medRxiv screened 2.4 million users of a symptom reporting application during the coronavirus disease (COVID-19) pandemic, revealing that smokers are at higher risk of increased symptom burden and more prone to hospitalization.

24 May 2020

Treatment with chloroquine or hydroxychloroquine offers no benefit for COVID-19 patients

A large observational study suggests that treatment with the antimalarial drug chloroquine or its analog hydroxychloroquine (taken with or without the antibiotics azithromycin or clarithromycin) offers no benefit for patients with COVID-19.

22 May 2020

Study focuses on COVID-19 patients with inflammatory rheumatic diseases

The ongoing COVID-19 pandemic has caused nearly five million cases and over 327,000 deaths worldwide. The signs and symptoms of this disease are varied, although there are typical features which assist diagnosis.

20 May 2020

Study highlights need to focus on medications that address clot formation

Earlier this week, the BBC reported that one-third of COVID-19 patients developed dangerous blood clots.

19 May 2020

Mount Sinai researchers are first to use AI model to analyze COVID-19 patients

Mount Sinai researchers are the first in the country to use artificial intelligence (AI) combined with imaging, and clinical data to analyze patients with coronavirus disease (COVID-19).

19 May 2020

Experts publish a review of lung cancer treatments for patients with COVID-19

Lung cancer patients are at heightened risk for COVID-19 and the reported high mortality rate among lung cancer patients with COVID-19 has given pause to oncologists who are faced with patients with not one, but two severe, life-threatening diseases.

15 May 2020

Two new devices could offer additional safety for health care workers during COVID-19

Treating patients with COVID-19 means health care workers are putting their own health and safety on the line each day.

14 May 2020

Does HIV infection increase the severity of COVID-19?

A new study by researchers at the New York University Grossman School of Medicine and published on the preprint server medRxiv* in May 2020 reports that being infected with HIV at the time of acquiring COVID-19 does not significantly increase the severity of illness or the risk of complications.

13 May 2020

Study shows why older individuals are vulnerable to COVID-19

A group of tiny RNA that should attack the virus causing COVID-19 when it tries to infect the body are diminished with age and chronic health problems, a decrease that likely helps explain why older individuals and those with preexisting medical conditions are vulnerable populations, investigators report.

13 May 2020

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Scientists around the globe are working to identify approved and investigational drugs that can be repurposed to treat COVID-19.

13 May 2020

COVID-19 pandemic is taking toll on mental and physical health of smokers

The havoc wreaked by the COVID-19 pandemic is twofold: in addition to suffering direct effects of the virus, the world is grappling with the challenge of social distancing.

13 May 2020

‘No intubation’: Seniors fearful of COVID-19 are changing their living wills

Last month, Minna Buck revised a document specifying her wishes should she become critically ill.

12 May 2020

Does cholesterol play a role in COVID-19?

A new study published on the preprint server bioRxiv in May 2020 suggests that the strikingly increased mortality in COVID-19 patients who are either old or also have high blood pressure, diabetes, cardiovascular disease is due to high tissue cholesterol levels. It also indicates the role of a healthy diet, by showing that polyunsaturated fatty acids (PUFA) in blood oppose the effects of cholesterol and thus the risk for severe COVID-19 symptoms.

12 May 2020

Lung Disease News and Research

Study maps novel coronavirus infection in cells of nasal cavity, airway and lungs

Expert offers COVID-19 guidance for patients with COPD

How comorbidities affect SARS-CoV-2 viral entry

Study shows children and adults have a comparable expression of SARS-CoV-2 entry-related genes

Zero benefit of Hydroxychloroquine or Chloroquine in COVID-19, says extensive study

Children with COVID-19 presenting with sudden severe lung disease

Capillary leakage important in COVID-19 respiratory distress

Smokers at increased risk of severe COVID-19 according to a large population study

Treatment with chloroquine or hydroxychloroquine offers no benefit for COVID-19 patients

Study focuses on COVID-19 patients with inflammatory rheumatic diseases

Study highlights need to focus on medications that address clot formation

Mount Sinai researchers are first to use AI model to analyze COVID-19 patients

Experts publish a review of lung cancer treatments for patients with COVID-19

Two new devices could offer additional safety for health care workers during COVID-19

Does HIV infection increase the severity of COVID-19?

Study shows why older individuals are vulnerable to COVID-19

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

COVID-19 pandemic is taking toll on mental and physical health of smokers

‘No intubation’: Seniors fearful of COVID-19 are changing their living wills

Does cholesterol play a role in COVID-19?

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