Clinical Trial News and Research

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Researchers use genetic manipulation to regenerate auditory hair cells in adult mice

In an apparent first, St. Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice. The research marks a possible advance in treatment of hearing loss in humans. The study appears today in the journal Cell Reports.

11 Apr 2017

FDA grants approval for first drug to treat adults with tardive dyskinesia

The U.S. Food and Drug Administration today approved Ingrezza (valbenazine) capsules to treat adults with tardive dyskinesia. This is the first drug approved by the FDA for this condition.

11 Apr 2017

Study identifies potential link between genes and treatment response in children with CAE

Consider two children who have childhood absence epilepsy (CAE), the most common form of pediatric epilepsy. They both take the same drug--one child sees an improvement in their seizures, but the other does not.

11 Apr 2017

Scientists discover promising target to treat highly aggressive brain tumor in infants

Using state-of-the-art gene editing technology, scientists from Ann & Robert H. Lurie Children's Hospital of Chicago have discovered a promising target to treat atypical teratoid/rhabdoid tumor (AT/RT) – a highly aggressive and therapy resistant brain tumor that mostly occurs in infants.

11 Apr 2017

Weather-forecast tool can help improve assessment and treatment of newborns with asphyxia

UT Southwestern Medical Center pediatric researchers have harnessed an analytical tool used to predict the weather to evaluate the effectiveness of therapies to reduce brain injury in newborns who suffer oxygen deprivation during birth.

10 Apr 2017

FDA grants approval for two drugs to treat hepatitis C virus in children

The U.S. Food and Drug Administration today approved supplemental applications for Sovaldi (sofosbuvir) and Harvoni (ledipasvir and sofosbuvir) to treat hepatitis C virus (HCV) in children ages 12 to 17. Harvoni and Sovaldi were previously approved to treat HCV in adults.

7 Apr 2017

Biomedical engineers develop new method for delivering drugs to specific neurons

Biomedical engineers have developed a way to deliver drugs to specific types of neurons in the brain, providing an unprecedented ability to study neurological diseases while also promising a more targeted way to treat them.

6 Apr 2017

Expert encourages cardiologists to continue using conventional drug-eluting stents

In a New England Journal of Medicine editorial published last week, Debabrata Mukherjee, M.D., provides expert commentary on bioresorbable stents, an alternative to the traditional stents used in patients with cardiac conditions.

6 Apr 2017

Clinical study examines impact of yoga on side-effects caused by prostate cancer treatment

Men who attended a structured yoga class twice a week during prostate cancer radiation treatment reported less fatigue and better sexual and urinary function than those who didn't, according to a clinical trial led by the Perelman School of Medicine at the University of Pennsylvania.

6 Apr 2017

MedCision announce program for companies undergoing early cell therapy trials

Limited-time program to help companies and investigators de-risk thawing of cell therapies in early stage clinical trials.

6 Apr 2017

Protocol violations in reduced radiotherapy lead to worse outcomes in children with brain tumors

A team of investigators has determined that young children participating in a clinical trial to assess the effectiveness of reduced radiotherapy did worse when there were deviations from the treatment protocol.

6 Apr 2017

Researchers achieve new step towards treatment of myotubular myopathy using gene therapy

A team of researchers in France, led by Dr. Ana Buj-Bello (Genethon/Inserm) and teams at the University of Washington and Harvard Medical School in the United States, achieved a new step towards the treatment of myotubular myopathy by gene therapy.

5 Apr 2017

Multivitamin use not linked to risk of major cardiovascular disease events

More than half of older American adults take a daily multivitamin supplement, but evidence of any clear health benefits is scarce.

5 Apr 2017

Hand-held EEG device can quickly assess brain bleeding in head injuries

In a clinical trial conducted among adults in 11 hospitals, researchers have shown that a hand-held EEG device approved in 2016 by the U.S. Food and Drug Administration that is commercially available can quickly and with 97 percent accuracy rule out whether a person with a head injury likely has brain bleeding and needs further evaluation and treatment.

5 Apr 2017

Yoga may be valuable adjunct to conventional therapies for ulcerative colitis

Patients with ulcerative colitis, a chronic inflammatory bowel disease, often relapse at times of stress.

5 Apr 2017

Stanford-led researchers use microbubbles and ultrasound to detect malignant cancers

A team led by researchers from the Stanford University School of Medicine has demonstrated a way to diagnose cancer without resorting to surgery, raising the possibility of far fewer biopsies.

5 Apr 2017

Brain responds differently to images of high-calorie foods in obese children, study finds

Brain signals that should help tell us we are full after eating appear to be dulled in obese children, according to preliminary results of a new study being presented Monday at ENDO 2017, the Endocrine Society's 99th annual meeting in Orlando, Fla.

4 Apr 2017

VUMC clinical study to evaluate treatment methods for rotator cuff tears

Nitin Jain, M.D., MSPH, associate professor of Physical Medicine and Rehabilitation and Orthopaedics, has been awarded a $7.5 million contract to determine whether surgery or non-operative therapy works better for a common age-related injury that costs the health care systems billions of dollars -- rotator cuff tears.

3 Apr 2017

Patients' immune system profiles could be linked to effectiveness of cancer immunotherapy

Higher or lower levels of certain immune cells in cancer patients may be associated with how well they respond to immunotherapy, according to preliminary results of a study conducted by researchers at the University of Pittsburgh Cancer Institute.

3 Apr 2017

Amgen, UCB present romosozumab Phase 2 results at ENDO 2017

Amgen and UCB today announced results from the fourth year of a Phase 2 study showing the efficacy and safety of a second course of treatment with EVENITY™* (romosozumab), an investigational agent for postmenopausal women with osteoporosis.

3 Apr 2017

Clinical Trial News and Research

Researchers use genetic manipulation to regenerate auditory hair cells in adult mice

FDA grants approval for first drug to treat adults with tardive dyskinesia

Study identifies potential link between genes and treatment response in children with CAE

Scientists discover promising target to treat highly aggressive brain tumor in infants

Weather-forecast tool can help improve assessment and treatment of newborns with asphyxia

FDA grants approval for two drugs to treat hepatitis C virus in children

Biomedical engineers develop new method for delivering drugs to specific neurons

Expert encourages cardiologists to continue using conventional drug-eluting stents

Clinical study examines impact of yoga on side-effects caused by prostate cancer treatment

MedCision announce program for companies undergoing early cell therapy trials

Protocol violations in reduced radiotherapy lead to worse outcomes in children with brain tumors

Researchers achieve new step towards treatment of myotubular myopathy using gene therapy

Multivitamin use not linked to risk of major cardiovascular disease events

Hand-held EEG device can quickly assess brain bleeding in head injuries

Yoga may be valuable adjunct to conventional therapies for ulcerative colitis

Stanford-led researchers use microbubbles and ultrasound to detect malignant cancers

Brain responds differently to images of high-calorie foods in obese children, study finds

VUMC clinical study to evaluate treatment methods for rotator cuff tears

Patients' immune system profiles could be linked to effectiveness of cancer immunotherapy

Amgen, UCB present romosozumab Phase 2 results at ENDO 2017

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