Genes News and Research

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Scientists trace genetic roots of Chiari 1 malformation

About one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem.

28 Dec 2020

Scientists identify distinct sub-types of angiosarcomas to allow for targeted treatment

A new study led by clinician-scientists from the National Cancer Centre Singapore, with collaborators from research institutions worldwide, has found that angiosarcomas have unique genomic and immune profiles which allow them to be classified into three different subtypes.

28 Dec 2020

Protein encourages similar developing cells to clump together

Tohoku University scientists have, for the first time, provided experimental evidence that cell stickiness helps them stay sorted within correct compartments during development.

24 Dec 2020

Polygenic risk scores from multi-population data could improve IBD predictions

Using genetic data from nearly 30,000 people, Mount Sinai researchers have built risk scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis. The study was published in Gastroenterology on December 24.

24 Dec 2020

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

In a new study, released on the bioRxiv* preprint server, a team of researchers explores the antiviral potential of red blood cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19.

24 Dec 2020

Researchers create a molecular catalog that describes different types of neurons

Retinal ganglion cells (RGCs) are the bottleneck through which all visual impressions flow from the retina to the brain. A team from the Max Planck Institute of Neurobiology, University of California Berkeley and Harvard University created a molecular catalog that describes the different types of these neurons.

24 Dec 2020

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to generate drug resistance in cancer.

24 Dec 2020

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell.

24 Dec 2020

Researchers discover how shattered chromosomes make cancer cells more aggressive

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.

23 Dec 2020

Study presents novel gene therapy for deafness

A new study from Tel Aviv University presents an innovative treatment for deafness, based on the delivery of genetic material into the cells of the inner ear.

23 Dec 2020

Forward genetics used to identify gene linked to autism spectrum disorder

UT Southwestern scientists have adapted a classic research technique called forward genetics to identify new genes involved in autism spectrum disorder (ASD).

23 Dec 2020

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

A recent computational study from India implicated a dysregulated vitamin D pathway in the pathobiology of the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and opened the door for experimental validation of these observations.

23 Dec 2020

SARS-CoV-2 mutations may evade T cell immunity

A potentially disturbing new study suggests that SARS-CoV-2 may be undergoing strategic mutations that affect the host immune capacity to recognize and combat the pathogen via T effector cells.

23 Dec 2020

COVID-19 severity could be linked to genetic variance

A new study describes some potentially important genetic factors in the host that may shape the clinical symptoms and signs of the disease.

23 Dec 2020

Researchers use fruit fly model to understand COVID-19-related neurological complications

Researchers claim to have reproduced disease mechanisms due to coronavirus disease 2019 (COVID-19) in the fruit fly, Drosophila, while also providing proof of the efficacy of one drug against these disease processes. If validated, these findings represent a new understanding of how the virus causes neurological symptoms that could help develop more effective therapies.

23 Dec 2020

Novel computational tool can systematically analyze cell images in C. elegans

A joint research team co-led by City University of Hong Kong (CityU) has developed a novel computational tool that can reconstruct and visualise three-dimensional (3D) shapes and temporal changes of cells, speeding up the analysing process from hundreds of hours by hand to a few hours by the computer.

23 Dec 2020

Researchers discover protein that adjusts gene activity to match nutrient levels in roundworms

Transforming a fertilized egg into a fully functional adult is a complicated task. Cells must divide, move, and mature at specific times. Developmental genes control that process, turning on and off in a choreographed way.

23 Dec 2020

Alterations in fetal microglia may lead to developmental and psychiatric disorders

Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders.

23 Dec 2020

Transcription factors in the brain strongly correlate with the behavior of honey bees

An unusual study that involved bar coding and tracking the behavior of thousands of individual honey bees in six queenless bee hives and analyzing gene expression in their brains offers new insights into how gene regulation contributes to social behavior.

23 Dec 2020

New mammogram-based measures could substantially improve screening

World-first techniques for predicting breast cancer risk from mammograms that were developed in Melbourne could revolutionize breast screening by allowing it to be tailored to women at minimal extra cost.

22 Dec 2020

Genes News and Research

Scientists trace genetic roots of Chiari 1 malformation

Scientists identify distinct sub-types of angiosarcomas to allow for targeted treatment

Protein encourages similar developing cells to clump together

Polygenic risk scores from multi-population data could improve IBD predictions

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

Researchers create a molecular catalog that describes different types of neurons

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

Researchers discover how shattered chromosomes make cancer cells more aggressive

Study presents novel gene therapy for deafness

Forward genetics used to identify gene linked to autism spectrum disorder

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

SARS-CoV-2 mutations may evade T cell immunity

COVID-19 severity could be linked to genetic variance

Researchers use fruit fly model to understand COVID-19-related neurological complications

Novel computational tool can systematically analyze cell images in C. elegans

Researchers discover protein that adjusts gene activity to match nutrient levels in roundworms

Alterations in fetal microglia may lead to developmental and psychiatric disorders

Transcription factors in the brain strongly correlate with the behavior of honey bees

New mammogram-based measures could substantially improve screening

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