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Early life stress encodes lifelong susceptibility to depression through alterations in brain reward region

Early life stress encodes lifelong susceptibility to stress through long-lasting transcriptional programming in a brain reward region implicated in mood and depression, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 15 in the journal Science.

15 Jun 2017

TSRI scientist and partners receive $7.2 million grant to create new RNA-based treatments for ALS

Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute, together with scientists from Mayo Clinic's Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).

15 Jun 2017

Study identifies new susceptibility loci for lung cancer

Using the OncoArray genotyping platform developed by multiple cancer consortia, a recent large aggregated genomewide association study identifies new susceptibility loci for lung cancer, the leading cause of cancer mortality worldwide.

14 Jun 2017

UAB researchers demonstrate persistence of donor microbes in recipients after fecal transplant

University of Alabama at Birmingham researchers have made the first direct demonstration that fecal donor microbes remained in recipients for months or years after a transplant to treat the diarrhea and colitis caused by recurrent Clostridium difficile infections -- a serious and stubborn cause of diarrhea after an antibiotic treatment for some other illness.

14 Jun 2017

UNC study uncovers crucial function of key enzyme found in virtually all organisms

UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria.

13 Jun 2017

Study uncovers new genetic markers linked to testicular germ cell tumors

Testicular cancer is relatively rare with only 8,850 cases expected this year in the United States. A majority of testicular cancer, 95 percent of all cases, begins in testicular germ cells, which are the cells responsible for producing sperm.

13 Jun 2017

New HPV vaccine could prevent most infections and millions of cancers

Cervical cancer affects more than half a million women and causes more than a quarter of a million deaths each year globally.

13 Jun 2017

Scientists create method for mapping genome-wide DNA damage caused by chemical carcinogen

Scientists have known for decades that smoking cigarettes causes DNA damage, which leads to lung cancer. Now, for the first time, UNC School of Medicine scientists created a method for effectively mapping that DNA damage at high resolution across the genome.

13 Jun 2017

Dietary practices get reflected in the genes of Europeans, study reveals

A recently published Cornell University study describes how shifts in the diets of Europeans after the introduction of farming 10,000 years ago led to genetic adaptations that favored the dietary trends of the time.

13 Jun 2017

Penn analysis finds genetic factors that could help identify men at increased risk for testicular cancer

An analysis of data from five major studies of testicular cancer has identified new genetic locations that could be susceptible to inherited testicular germ cell tumors.

12 Jun 2017

Anorexia nervosa linked to genetic anomalies on chromosome 12

A large-scale, international whole-genome analysis has now revealed for the first time that anorexia nervosa is associated with genetic anomalies on chromosome 12.

12 Jun 2017

KAUST-led researchers reveal epigenetic mechanism for gene regulation

An epigenetic mechanism regulating gene activity has been revealed by a KAUST-led international team of researchers investigating interactions between the human genome and its environment in adult tissues.

12 Jun 2017

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that half of the patients respond to an immunotherapy drug called pembrolizumab.

9 Jun 2017

‘Wholesome’ breads may not necessarily be healthiest choice for everyone, study reveals

Bread occupies a unique place in our diet: it accounts for about one-tenth of the calories many people in the West consume and up to 40 percent of the caloric consumption in some non-Western countries – more than any other food product.

9 Jun 2017

Study finds evidence that genes influence empathy

New research has found empathy may have a genetic component that also influences personality, cognition, and psychiatric conditions. Further, although not a novel finding, researchers noted women generally performed better on a test used to gauge empathy than their male counterparts.

9 Jun 2017

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

It is almost axiomatic in medicine that the study of rare disorders informs the understanding of more common, widespread ailments.

8 Jun 2017

New findings highlight possibility of developing specific cancer drugs with fewer side effects

Scientists at Karolinska Institutet in Sweden report that cancer cells and normal cells use different 'gene switches' in order to regulate the expression of genes that control growth.

6 Jun 2017

Greater gut bacteria diversity linked to longer progression-free survival in metastatic melanoma patients

The blend of bacteria in the digestive tract of metastatic melanoma patients is associated with disease progression or delay in patients treated with immunotherapy, researchers at The University of Texas MD Anderson Cancer Center report at the 2017 annual meeting of the American Society of Clinical Oncology.

6 Jun 2017

Researchers uncover protective mechanism of rotifers that may have implications for aging research

Rotifers are tough, microscopic organisms highly resistant to radiation and repeated cycles of dehydration and rehydration.

6 Jun 2017

New genomic sequencing approach could be first step toward blood tests for early cancer detection

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high-intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

5 Jun 2017

Genome News and Research

Early life stress encodes lifelong susceptibility to depression through alterations in brain reward region

TSRI scientist and partners receive $7.2 million grant to create new RNA-based treatments for ALS

Study identifies new susceptibility loci for lung cancer

UAB researchers demonstrate persistence of donor microbes in recipients after fecal transplant

UNC study uncovers crucial function of key enzyme found in virtually all organisms

Study uncovers new genetic markers linked to testicular germ cell tumors

New HPV vaccine could prevent most infections and millions of cancers

Scientists create method for mapping genome-wide DNA damage caused by chemical carcinogen

Dietary practices get reflected in the genes of Europeans, study reveals

Penn analysis finds genetic factors that could help identify men at increased risk for testicular cancer

Anorexia nervosa linked to genetic anomalies on chromosome 12

KAUST-led researchers reveal epigenetic mechanism for gene regulation

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

‘Wholesome’ breads may not necessarily be healthiest choice for everyone, study reveals

Study finds evidence that genes influence empathy

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

New findings highlight possibility of developing specific cancer drugs with fewer side effects

Greater gut bacteria diversity linked to longer progression-free survival in metastatic melanoma patients

Researchers uncover protective mechanism of rotifers that may have implications for aging research

New genomic sequencing approach could be first step toward blood tests for early cancer detection

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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