Molecule News and Research

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Small-molecule drug simultaneously rejuvenates old muscles, aging brains

Whether you're brainy, brawny or both, you may someday benefit from a drug found to rejuvenate aging brain and muscle tissue. Researchers at the University of California, Berkeley, have discovered that a small-molecule drug simultaneously perks up old stem cells in the brains and muscles of mice, a finding that could lead to drug interventions for humans that would make aging tissues throughout the body act young again.

14 May 2015

Regulatory T cells can cure inflammatory diseases, shows research

Scientists at The University of Manchester have made an important discovery about an immune cell which is already being used in immunotherapy to treat diseases such as type I diabetes.

14 May 2015

Researchers submit patent application for drug that could destroy acute lymphoblastic leukemia

A patent application for a drug that could destroy the deadly childhood disease known as acute lymphoblastic leukemia — and potentially other cancers as well — has been submitted by researchers at Sandia National Laboratories, the University of Maryland and the MD Anderson Cancer Center in Houston.

14 May 2015

TSRI researchers find interferon beta protein as prime suspect in persistent viral infections

Interferon proteins are normally considered virus-fighters, but scientists at The Scripps Research Institute have found evidence that one of them, interferon beta (IFNβ), has an immune-suppressing effect that can help some viruses establish persistent infections.

14 May 2015

Discovery could help identify molecules that selectively target cancer cells

A new family of molecules that kill cancer cells and protect healthy cells could be used to treat a number of different cancers, including cervical, breast, ovarian and lung cancers. Research published in EBioMedicine shows that as well as targeting and killing cancer cells, the molecules generate a protective effect against toxic chemicals in healthy cells.

13 May 2015

Australian researchers discover rogue germinal centre B cells that trigger autoimmune disease

Australian researchers believe they have discovered a group of cells that trigger autoimmune disease, as well as the molecular 'trigger guard' that normally holds them in check.

13 May 2015

Scientists uncover mechanism behind 'tubulin code'

Driving down the highway, you encounter ever-changing signs -- speed limits, exits, food and gas options. Seeing these roadside markers may cause you to slow down, change lanes or start thinking about lunch. In a similar way, cellular structures called microtubules are tagged with a variety of chemical markers that can influence cell functions.

13 May 2015

Study: Disrupting cancer pathway could extend benefits of new immunity-boosting drugs

Understanding how to overrule a signaling pathway that can cause treatments to fail in metastatic melanoma patients should help physicians extend the benefits of recently approved immunity-boosting drugs known as checkpoint inhibitors to more patients.

12 May 2015

Malfunction of brain architecture can prompt neuron to make 'early-career' switch

Scientists at the Salk Institute have discovered that the role of neurons -- which are responsible for specific tasks in the brain -- is much more flexible than previously believed.

12 May 2015

New method may help determine potential indicator of stress, neurological disorders

A research collaboration between the universities of Oslo and Aarhus has resulted in the development of a new method with diagnostic potential. The new method that combines phase extraction with an enzymatic reaction may eventually be used for an improved and faster screening analysis of isatin as a potential indicator of stress and neurological disorders.

12 May 2015

Can-Fite receives EMA clearance to begin CF102 Phase II trial for treatment of HCC patients in Europe

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs being developed to treat inflammatory diseases, cancer and sexual dysfunction, today announced it recently received clearance from the European Medicines Agency to commence dosing patients in Europe in its global Phase II trial for CF102 in the treatment of hepatocellular carcinoma (HCC), the most common form of liver cancer.

11 May 2015

Study sheds light on developing more targeted therapies against medulloblastoma

St. Jude Children's Research Hospital scientists have gained ground toward developing more targeted therapies for the most common childhood brain tumor.

10 May 2015

Knowing the physical structure of amyloid beta-42 offers new view on amyloid propagation in Alzheimer's

Researchers at the University of Illinois at Chicago have determined the molecular structure of one of the proteins in the fine fibers of the brain plaques that are a hallmark of Alzheimer's disease. This molecule, called amyloid beta-42, is toxic to nerve cells and is believed to provoke the disease cascade.

8 May 2015

Removing bacterial biofilms could help prevent and treat colon cancers, study suggests

A team led by scientists at The Scripps Research Institute and Johns Hopkins University School of Medicine has uncovered a big clue to how bacteria may promote some colon cancers.

8 May 2015

Quantitative phosphoproteomic approach to identify targeted cancer therapy

Winner of the Louise Eisenhardt Traveling Scholarship Award, Teresa Purzner, MD, presented her research, Quantitative Phosphoproteomics for Targeted Cancer Therapy.

7 May 2015

MSI completes patient recruitment for STRADA Phase 2 trial for treatment of major depressive disorder

MSI Methylation Sciences, Inc., a pharmaceutical company developing a once-daily oral, small molecule therapy for adjunctive treatment of major depressive disorder (MDD), announced the completion of patient recruitment for its HORIZON Phase 2 Study.

7 May 2015

Cardiff scientists develop novel anti-cancer stem cell compound

Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.

7 May 2015

Adelaide researchers identify target for developing new antibiotics against disease-causing bacteria

University of Adelaide researchers have discovered a target for the development of completely new antibiotics against disease-causing bacteria.

7 May 2015

Researchers report novel approach to combat multidrug-resistant bacterial pathogens

With the threat of multidrug-resistant bacterial pathogens growing, new ideas to treat infections are sorely needed. Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences report preliminary success testing an entirely novel approach -- tagging bacteria with a molecular "homing beacon" that attracts pre-existing antibodies to attack the pathogens.

7 May 2015

Luxembourg biologists provide complete image of human 'miRNome' in blood samples

In an elaborate study, biologists of the University of Luxembourg have found out that small molecules named microRNAs are, against many hopes, not yet suitable for early diagnosis of skin cancer, as well as supposedly for other types of cancer, in blood samples. For the first time they analysed all microRNAs in the serum of healthy people and thus provided a first complete image of the human "miRNome" in blood samples, in reference to the better-known "genome".

6 May 2015

Molecule News and Research

Small-molecule drug simultaneously rejuvenates old muscles, aging brains

Regulatory T cells can cure inflammatory diseases, shows research

Researchers submit patent application for drug that could destroy acute lymphoblastic leukemia

TSRI researchers find interferon beta protein as prime suspect in persistent viral infections

Discovery could help identify molecules that selectively target cancer cells

Australian researchers discover rogue germinal centre B cells that trigger autoimmune disease

Scientists uncover mechanism behind 'tubulin code'

Study: Disrupting cancer pathway could extend benefits of new immunity-boosting drugs

Malfunction of brain architecture can prompt neuron to make 'early-career' switch

New method may help determine potential indicator of stress, neurological disorders

Can-Fite receives EMA clearance to begin CF102 Phase II trial for treatment of HCC patients in Europe

Study sheds light on developing more targeted therapies against medulloblastoma

Knowing the physical structure of amyloid beta-42 offers new view on amyloid propagation in Alzheimer's

Removing bacterial biofilms could help prevent and treat colon cancers, study suggests

Quantitative phosphoproteomic approach to identify targeted cancer therapy

MSI completes patient recruitment for STRADA Phase 2 trial for treatment of major depressive disorder

Cardiff scientists develop novel anti-cancer stem cell compound

Adelaide researchers identify target for developing new antibiotics against disease-causing bacteria

Researchers report novel approach to combat multidrug-resistant bacterial pathogens

Luxembourg biologists provide complete image of human 'miRNome' in blood samples

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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