Mutation News and Research

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Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

What keeps leukemia cells alive almost forever, able to continue dividing endlessly and aggressively? New research at the Weizmann Institute suggests that, in around a quarter of all leukemias, the cancer cells rely on an internal "balance of terror" to keep going.

1 Oct 2013

New approaches needed for testing cancer drugs

Research institutes, regulators and the pharmaceutical industry are urged to cooperate to develop new approaches to testing cancer drugs, in order to bring the revolution in personalised medicine to patients across Europe, says the European Society for Medical Oncology.

1 Oct 2013

Researchers discover how aspirin improves survival in patients diagnosed with colon cancer

Researchers believe they have discovered how aspirin improves survival in patients diagnosed with colon cancer, the 2013 European Cancer Congress (ECC2013) heard today.

1 Oct 2013

Study shows direct causative link between obesity and risk of pancreatic cancer in mice

Researchers at UCLA's Jonsson Comprehensive Cancer Center (JCCC) have found that mice made obese by being given high-calorie, high-fat diets (HFCD) developed abnormally high numbers of lesions known as pancreatic intraepithelial neoplasias (PanINs), which are known to be precursors to pancreas cancer.

1 Oct 2013

Huntsman investigator receives $1.5M to focus on c-KIT gene's role in melanoma

The National Cancer Institute (NCI) has awarded Huntsman Cancer Institute investigator Matt VanBrocklin, Ph.D., more than $1.5 million over the next five years to continue studying the role of a gene called c-KIT in the origin and growth of melanoma, a devastating and sometimes deadly skin cancer.

1 Oct 2013

Researchers discover how aspirin improves survival in patients with colon cancer

Researchers believe they have discovered how aspirin improves survival in patients diagnosed with colon cancer, the 2013 European Cancer Congress heard today (Monday).

30 Sep 2013

Biology of tumour more important than primary site, say researchers

Identifying the molecular profile of a tumour where the primary site is unknown is crucial to the choice of treatment, the 2013 European Cancer Congress, will hear on Monday.

30 Sep 2013

Scientists discover two new compounds that could help treat CF patients having common mutation

Cystic fibrosis is a lethal genetic disorder that in France affects one child per 4,500 births. An international team led by scientists at the Institut Fédératif de Recherche Necker-Enfants Malades (CNRS/Inserm/Université Paris Descartes), led by Aleksander Edelman, has recently discovered two new compounds that could be used to treat patients carrying the most common mutation.

30 Sep 2013

Study suggests relationship between smoking history, response to inhibiting PD-L1/PD-1 pathway

New results from a trial of an antibody that helps the immune system to recognise and attack cancer cells have shown particularly encouraging responses in patients who are smokers or former smokers.

30 Sep 2013

Discoveries pave way for use of new therapies for advanced thyroid cancer

For many years, patients with advanced thyroid cancer faced bleak prospects and no viable treatment options. But now, building on recent discoveries about the genetics and cell signaling pathways of thyroid tumors, researchers are developing exciting new weapons against the disease, using kinase inhibitors that target tumor cell division and blood vessels.

30 Sep 2013

Researchers discover severe health consequences of folic acid deficiency

Researchers from the universities of Calgary and Cambridge, UK, have discovered that a mutation in a gene necessary for the metabolism of folic acid not only impacts immediate offspring but can also have detrimental health effects, such as spina bifida and heart abnormalities, on subsequent generations.

29 Sep 2013

Scientists identify 140 regions of genetic code believed to contain undiscovered cancer genes

Scanning the DNA of nearly 5,000 tumor samples, a team led by scientists at Dana-Farber Cancer Institute and the Broad Institute has identified 140 regions of scrambled genetic code believed to contain many undiscovered cancer genes.

29 Sep 2013

Research opens up possibility for new treatment approaches for motor neurone disease

New research from the University of Sheffield could offer solutions into slowing down the progression of motor neurone disease.

28 Sep 2013

Pan-Cancer Initiative: Patterns Emerge Across Diverse Tumor Types

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27 Sep 2013

Scientists unravel secrets of mechanism that snips our genes

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing.

27 Sep 2013

Mayo Clinic experts to discuss risk factors, screening and treatments for breast cancer

October is National Breast Cancer Awareness Month, and Mayo Clinic breast cancer experts are available to discuss risk factors, screening and treatments.

27 Sep 2013

Folic acid deficiency may be associated with multi-generational impact on health

Folic acid deficiency can cause severe health problems in offspring, including spina bifida, heart defects and placental abnormalities. A study out today reveals that a mutation in a gene necessary for the metabolism of folic acid not only impacts the immediate offspring but can also have detrimental health effects on the next several generations.

27 Sep 2013

Icotinib matches gefitinib in NSCLC second or third line

Icotinib has been found to be noninferior to gefitinib in patients with non-small-cell lung cancer, according to reports from the phase III Chinese double-blind ICOGEN study.

26 Sep 2013

Researchers identify mutation in ITGA10 gene that causes chondrodysplasia in dog breeds

Professor Hannes Lohi's research group at the University of Helsinki and Folkhälsan Research Center has identified a mutation in ITGA10 gene, causing chondrodysplasia in two dog breeds, the Norwegian Elkhound and the Karelian Bear Dog.

26 Sep 2013

Scientists develop model to study the behavior of embryonic tissue

A team of scientists, including M. Lisa Manning, assistant professor of physics in Syracuse University's College of Arts and Sciences, has developed a model for studying tissue-specifically how it organizes into organs and layers during embryonic development.

26 Sep 2013

Mutation News and Research

Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

New approaches needed for testing cancer drugs

Researchers discover how aspirin improves survival in patients diagnosed with colon cancer

Study shows direct causative link between obesity and risk of pancreatic cancer in mice

Huntsman investigator receives $1.5M to focus on c-KIT gene's role in melanoma

Researchers discover how aspirin improves survival in patients with colon cancer

Biology of tumour more important than primary site, say researchers

Scientists discover two new compounds that could help treat CF patients having common mutation

Study suggests relationship between smoking history, response to inhibiting PD-L1/PD-1 pathway

Discoveries pave way for use of new therapies for advanced thyroid cancer

Researchers discover severe health consequences of folic acid deficiency

Scientists identify 140 regions of genetic code believed to contain undiscovered cancer genes

Research opens up possibility for new treatment approaches for motor neurone disease

Pan-Cancer Initiative: Patterns Emerge Across Diverse Tumor Types

Scientists unravel secrets of mechanism that snips our genes

Mayo Clinic experts to discuss risk factors, screening and treatments for breast cancer

Folic acid deficiency may be associated with multi-generational impact on health

Icotinib matches gefitinib in NSCLC second or third line

Researchers identify mutation in ITGA10 gene that causes chondrodysplasia in dog breeds

Scientists develop model to study the behavior of embryonic tissue

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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