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GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Are we moving closer to the day when diabetes is no longer monitored and managed with blood sugar tests, insulin injections and drug treatments? A GE Research-led team, which includes The Feinstein Institutes for Medical Research, UCLA Samueli School of Engineering, Yale School of Medicine, and Albany Medical College, has demonstrated the ability to prevent or reverse the onset of diabetes in studies of three different preclinical model systems.

31 Mar 2022

Johns Hopkins researchers explore the link between psychedelics and consciousness

Psychedelic drugs, like psilocybin, an ingredient found in so-called magic mushrooms, have shown promise in treating a range of addictions and mental health disorders.

31 Mar 2022

Higher doses of anti-seizure drugs may be necessary to maintain seizure control in pregnant women

Women taking anti-seizure medications during pregnancy experienced significant decreases in serum concentrations for such drugs during their pregnancy, according to a study published in JAMA Neurology.

31 Mar 2022

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

A new study identified mechanisms regulating immune cell plasticity to develop new therapeutics.

31 Mar 2022

Liposomes tailored for pulmonary delivery for treating acute respiratory distress syndrome

Researchers developed 1,2-dimpalmiyristoyl-sn-glycero-3-phosphocholine liposomes co-loaded with methylprednisolone and N-acetyl cysteine to treat acute respiratory distress syndrome in vivo.

31 Mar 2022

Despite doctors’ concerns, pharmacists get more leeway to offer treatment with testing

When Reyna or Justin Ansley or one of their three kids feels sick and needs to be tested for strep throat or flu, there's a good chance they'll head to their local pharmacy in Hemingford or Alliance, Nebraska. Dave Randolph, the proprietor of both locations of Dave's Pharmacy, can do a rapid test, give them medicine if they need it, and send them on their way.

31 Mar 2022

Study identifies a set of sporadic genetic mutations behind cavernous angioma

A rare type of brain blood vessel malformation known as a cavernous angioma affects more than one million Americans and carries a lifetime risk of stroke and seizures.

30 Mar 2022

Research provides a roadmap for new therapies to treat chorioamnionitis

One of the serious complications that can occur during late pregnancy happens when the amniotic sac (also called the bag of waters) breaks too early, which can allow bacterial infections to cause dangerous tissue inflammation around the placenta.

30 Mar 2022

New antidiabetic substance preserves the activity of beta cells, prevents high blood glucose in mice

High blood glucose is responsible for several complications in type 1 and type 2 diabetes. Researchers at Karolinska Institutet in Sweden have identified a new antidiabetic substance that preserves the activity of insulin-producing beta cells and prevents high blood glucose in mice.

30 Mar 2022

New tactic to disrupt cancer repair mechanism could lead to a potential treatment strategy

While cancer therapies targeting specific genes or disease pathways have extended lives, they can also lead to highly resistant tumors when small reservoirs of cancer cells survive treatment, grow, and spread.

30 Mar 2022

Researchers discover potential link between inflammation and structure of specific brain regions

A potential link between inflammation and the structure of specific regions of the brain has been identified by researchers at the University of Birmingham.

30 Mar 2022

Scientists create a biobank of 87 triple-negative breast cancer organoids

It's the cancer version of "mini me." Cold Spring Harbor Laboratory (CSHL) Professor David Spector, among others, has developed organoids, which are miniature, three-dimensional copies of cancers. Organoids can be derived from cancer or healthy cells.

30 Mar 2022

NYU Langone joins NIH-sponsored program as leading center to discover new targets for autoimmune, inflammatory diseases

NYU Langone Health is joining a new National Institutes of Health (NIH)-sponsored program called Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM) as a leading center to discover new targets for therapy in these diseases.

30 Mar 2022

Covid and schizophrenia: Why this deadly mix can deepen knowledge of the brain disease

Most of the time, the voices in Keris Myrick’s head don’t bother her. They stay in the background or say nice things. But sometimes they get loud and mean — like when a deadly pandemic descended on the world.

30 Mar 2022

The potential efficacy of nasal nanoparticle COVID-19 vaccines

The current paper reviews progress in this field regarding nasal nanoparticle vaccines for COVID-19.

30 Mar 2022

Researchers present a possible therapeutic approach for severe congenital myopathy

The diagnosis is rare, but devastating – children with congenital muscle disorders often never learn to walk. Until now, there was no chance of recovery, but researchers at the University of Basel and University Hospital Basel are now presenting a possible therapeutic approach for the first time.

29 Mar 2022

Study shows clinical value of pharmacogenomic testing for patients with treatment-resistant depression

Pharmacogenetic testing was associated with nearly a two-fold (89 per cent) increase in remission rates compared to treatment as usual in a Centre for Addiction and Mental Health- (CAMH-)led clinical study just published in the journal Translational Psychiatry.

29 Mar 2022

FDA requests nearly 34% increase in funding as part of the President’s fiscal year 2023 budget

Today, the U.S. Food and Drug Administration announced it is requesting a total budget of $8.4 billion as part of the President's fiscal year (FY) 2023 budget - a nearly 34% ($2.1 billion) increase over the agency's FY 2022 appropriated funding level for investments in critical public health modernization, core food safety and medical product safety programs and other vital public health infrastructure.

29 Mar 2022

10-second videos of white blood cell motion improve the prediction of blood cancer relapse

In a new study from Vanderbilt University Medical Center, 10-second videos of white blood cell motion in the skin's microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.

29 Mar 2022

Researchers find possible window of opportunity to target astrocyte abnormalities during ALS treatment

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects as many as 30,000 people in the United States, with 5,000 new cases diagnosed each year. It weakens muscles over time, impacting physical function and ultimately leading to death.

29 Mar 2022

Drugs News and Research

GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Johns Hopkins researchers explore the link between psychedelics and consciousness

Higher doses of anti-seizure drugs may be necessary to maintain seizure control in pregnant women

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

Liposomes tailored for pulmonary delivery for treating acute respiratory distress syndrome

Despite doctors’ concerns, pharmacists get more leeway to offer treatment with testing

Study identifies a set of sporadic genetic mutations behind cavernous angioma

Research provides a roadmap for new therapies to treat chorioamnionitis

New antidiabetic substance preserves the activity of beta cells, prevents high blood glucose in mice

New tactic to disrupt cancer repair mechanism could lead to a potential treatment strategy

Researchers discover potential link between inflammation and structure of specific brain regions

Scientists create a biobank of 87 triple-negative breast cancer organoids

NYU Langone joins NIH-sponsored program as leading center to discover new targets for autoimmune, inflammatory diseases

Covid and schizophrenia: Why this deadly mix can deepen knowledge of the brain disease

The potential efficacy of nasal nanoparticle COVID-19 vaccines

Researchers present a possible therapeutic approach for severe congenital myopathy

Study shows clinical value of pharmacogenomic testing for patients with treatment-resistant depression

FDA requests nearly 34% increase in funding as part of the President’s fiscal year 2023 budget

10-second videos of white blood cell motion improve the prediction of blood cancer relapse

Researchers find possible window of opportunity to target astrocyte abnormalities during ALS treatment

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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