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An integrated molecular diagnostic approach for detecting SARS-CoV-2 variants

Researchers developed an integrated approach combining NGS, molecular barcoding, machine learning, and bioinformatics to enable high-throughput detection of SARS-CoV-2 variants.

23 Jun 2022

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T–cell therapy for treatment of solid tumors.

22 Jun 2022

Bacteria causing typhoid fever are highly developing antibiotic resistance

Bacteria causing Typhoid fever are becoming increasingly resistant to some of the most important antibiotics for human health, according to a study published in The Lancet Microbe journal. The largest genome analysis of Salmonella enterica serovar Typhi (S. Typhi) also reveals that resistant strains - almost all originating in South Asia - have spread to other countries nearly 200 times since 1990.

22 Jun 2022

Potential SARS-CoV-2 antivirals based on host miRNAs

A recent research paper posted to the bioRxiv* preprint server demonstrated micro ribonucleic acids (miRNAs) as potential antiviral options against various coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

21 Jun 2022

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as guided by Gag's N-terminal matrix domain.

21 Jun 2022

Scientists discover 15 additional genetic mutations linked to KCNK9 imprinting syndrome

A collaborative team of scientists led by Mayo Clinic's Center for Individualized Medicine has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome.

21 Jun 2022

Whole genome sequencing of 1,700-year-old individuals shows genetic heterogeneity in ancient Koreans from Gaya

An international team led by The University of Vienna and the Ulsan National Institute of Science and Technology in collaboration with the National Museum of Korea has successfully sequenced and studied the whole genome of eight 1,700-year-old individuals dated to the Three Kingdoms period of Korea (approx. 57 BC-668 AD).

21 Jun 2022

Breast cancer trial results may not translate to real-world outcomes based on treatment discontinuation

New research in the June 2022 issue of JNCCN - Journal of the National Comprehensive Cancer Network raises issues with clinical trial findings that show adjuvant hormone therapy (AHT)-related hot flashes predict better outcomes for estrogen receptor-positive (ER+) breast cancer.

21 Jun 2022

TB-causing bacteria can evolve rapidly in response to new environments, study says

Researchers have identified how the bacterium that causes tuberculosis (TB) can evolve rapidly in response to new environments, says a study published today in eLife.

21 Jun 2022

Lack of biodiversity in the gut or elevated metabolites associated with heart failure severity

Some people who experience heart failure have less biodiversity in their gut or have elevated gut metabolites, both of which are associated with more hospital visits and greater risk of death, according to a systematic review of research findings led by Georgetown University School of Nursing & Health Study researchers and colleagues.

21 Jun 2022

A class of protein-cleaving enzymes suspected to play a role in hereditary brain disease

Similar to Alzheimer's disease, the hereditary disease spinocerebellar ataxia type 17 (SCA17) leads to the destruction of brain nerve cells and the premature death of patients.

21 Jun 2022

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

The impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant

Researchers assessed the impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant.

21 Jun 2022

Increased docosahexaenoic acid intake may lower risk for Alzheimer’s and dementia

An increase in the concentration of DHA in RBCs is associated with a reduced risk of Alzheimer's disease and all-cause dementia

21 Jun 2022

Implications of impaired type I interferon immunity and increasing COVID-19 severity

Researchers demonstrated that impaired type I interferon immunity is associated with increasing coronavirus disease 2019 severity.

20 Jun 2022

Scientists explore brainstem circuits to find nausea intervention strategies

In a new study, researchers uncovered the organization of nausea-associated brainstem circuits to show that selectively blocking the excitatory neurons responsive to nausea-promoting growth/differentiation factor 15 suppresses nausea-related behaviors.

20 Jun 2022

Genetic discovery may pave the way to new diagnostic approaches, treatments for motor neurone diseases

A new genetic discovery adds weight to a theory that motor neurone degenerative diseases are caused by abnormal lipid (fat) processing pathways inside brain cells.

20 Jun 2022

Model predicts effectiveness of COVID-19 vaccines against circulating SARS-CoV-2 variants

In a recent study published in the journal Nature Medicine, researchers assessed the coronavirus disease 2019 (COVID-19) vaccine effectiveness (VE) against symptomatic infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and variants of interest (VOIs) by genetic mismatch/distance (GD) analysis.

20 Jun 2022

Traumatic brain injury changes the connections between nerve cells across the entire brain

Scientists from the University of California, Irvine have discovered that an injury to one part of the brain changes the connections between nerve cells across the entire brain.

17 Jun 2022

Women with premature births more often have gum disease, study finds

Women with preterm births may be more likely to have gum disease compared to those with full-term births, according to research presented at EuroPerio10, the world's leading congress in periodontology and implant dentistry organized by the European Federation of Periodontology.

17 Jun 2022

Genetic News and Research

An integrated molecular diagnostic approach for detecting SARS-CoV-2 variants

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Bacteria causing typhoid fever are highly developing antibiotic resistance

Potential SARS-CoV-2 antivirals based on host miRNAs

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Scientists discover 15 additional genetic mutations linked to KCNK9 imprinting syndrome

Whole genome sequencing of 1,700-year-old individuals shows genetic heterogeneity in ancient Koreans from Gaya

Breast cancer trial results may not translate to real-world outcomes based on treatment discontinuation

TB-causing bacteria can evolve rapidly in response to new environments, study says

Lack of biodiversity in the gut or elevated metabolites associated with heart failure severity

A class of protein-cleaving enzymes suspected to play a role in hereditary brain disease

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

The impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant

Increased docosahexaenoic acid intake may lower risk for Alzheimer’s and dementia

Implications of impaired type I interferon immunity and increasing COVID-19 severity

Scientists explore brainstem circuits to find nausea intervention strategies

Genetic discovery may pave the way to new diagnostic approaches, treatments for motor neurone diseases

Model predicts effectiveness of COVID-19 vaccines against circulating SARS-CoV-2 variants

Traumatic brain injury changes the connections between nerve cells across the entire brain

Women with premature births more often have gum disease, study finds

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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