Clinical Trial News and Research

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New antibody drug shows promising results to prevent or treat HIV

A new biologic agent--the most potent of its kind so far--is showing early promise as part of a potential new strategy for treating HIV. The drug, known as 10-1074, may also offer a new way to prevent viral infection in people who are at high risk to acquire HIV, the virus that causes AIDS.

7 Feb 2017

New method improves speed and diagnostic efficiency during brain surgery

A new approach to the practice of surgical pathology for brain tumor patients could make for a powerful combination: more accurate, safer and more efficient operations.

7 Feb 2017

Researcher creates molecular diagnostic system that can quickly identify dangerous bacteria

A Michigan State University researcher has developed a faster way to detect the bacteria causing patients to become sick, giving physicians a better chance at saving their lives.

3 Feb 2017

Yale researchers identify new genetic defect in brain tumor cells that prevents DNA repair

In a new study, Yale Cancer Center researchers identified a novel genetic defect that prevents brain tumor cells from repairing damaged DNA.

3 Feb 2017

Study paves way for therapies against myeloid-derived suppressor cells that collude with cancer

Some cells excite the immune system. Others soothe it. Myeloid-derived suppressor cells (MDSCs) are one type of soothing cell, and previous work shows that cancer may specifically boost production of MDSCs as a way to tamp down immune response against tumors. At least that's how it works in mice.

3 Feb 2017

New approach helps decide better treatment option for laryngeal cancer

Even as treatment options for laryngeal cancer seemed to improve, survival rates did not. For the most advanced patients, 50 percent survival was the norm, whether patients had surgery to totally remove the voice box or alternative treatment with chemotherapy and radiation to try to avoid surgery.

3 Feb 2017

Autologous hematopoietic cell transplant may induce sustained remission of multiple sclerosis

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person's own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system.

2 Feb 2017

Mayo Clinic to test vaccine for providing lifelong immunity against precancerous breast lesions

Only about 35 percent of precancerous breast lesions morph into cancer if untreated, but physicians cannot identify which lesions are potentially dangerous.

2 Feb 2017

UTHealth and Children's Memorial Hermann begin two new clinical trials for pediatric brain cancer

Two new clinical trials for pediatric brain cancer have begun at The University of Texas Health Science Center at Houston and Children's Memorial Hermann Hospital.

31 Jan 2017

Sanford clinical study exploring immunotherapy drug to treat patients with advanced esophageal cancer

A clinical trial at Sanford Health is studying if an immunotherapy drug developed by Merck might be able to treat certain patients with advanced esophageal cancer. The Merck Keynote 181 trial is now open at Sanford.

31 Jan 2017

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and develop alternative pharmacological treatment options.

31 Jan 2017

Researchers discover that existing anti-gout drug can reduce severity of opioid withdrawal symptoms

Opioid use and abuse is a significant social, health and economic issue in Canada. Researchers at the University of Calgary's Faculty of Veterinary Medicine and Hotchkiss Brain Institute have discovered that an existing anti-gout medication is effective in reducing the severity of withdrawal symptoms in opioid-dependent rodents.

30 Jan 2017

First-time drug trials launched on basis of flimsy, under-scrutinized evidence, say McGill researchers

Standards for authorizing first-time trials of drugs in humans are lax, and should be strengthened in several ways, McGill University researchers argue in a paper published today in Nature.

30 Jan 2017

Acupuncture improves effectiveness of standard treatment for chronic pain and depression

Health specialists at the University of York have found than acupuncture treatment can boost the effectiveness of standard medical care, lessening the severity of chronic pain and depression.

30 Jan 2017

ALCMI and Scancell collaborate to advance cancer vaccine clinical trials in NSCLC patients

The Addario Lung Cancer Medical Institute, the Bonnie J. Addario Lung Cancer Foundation and Scancell Holdings PLC today announce a collaboration to evaluate the use of Scancell's second innovative cancer vaccine, SCIB2, from its ImmunoBody platform to treat non-small cell lung cancer.

30 Jan 2017

Orthopaedic research helps nurse recover from knee injury

Working as a bedside nurse requires extensive physical effort — pushing wheelchairs and beds, twisting and lifting, and long periods on your feet.

28 Jan 2017

Hemodialysis patients do not wish to receive treatment for depression, study shows

Many patients with kidney failure who are receiving chronic hemodialysis have depressive symptoms but do not wish to receive aggressive treatment to alleviate them, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology.

28 Jan 2017

SLATE clinical trial uses Medtronic Visualase MRI-guided laser ablation system to treat common form of epilepsy

Medtronic plc announced today that the first procedure using the Visualase MRI-Guided Laser Ablation System has been performed in the pivotal SLATE (Stereotactic Laser Ablation for Temporal Lobe Epilepsy) clinical trial at Mayo Clinic in Rochester, Minn.

From Medtronic 27 Jan 2017

Body shaming may contribute to increased health risks

Body shaming is a pervasive form of prejudice, found in cyber bullying, critiques of celebrities' appearances, at work and school, and in public places for everyday Americans.

27 Jan 2017

New gene therapy for Pompe disease may replace currently available treatments

After decades investigating a rare, life-threatening condition that cripples the muscles, Duke Health researchers have developed a gene therapy they hope could enhance or even replace the only FDA-approved treatment currently available to patients.

27 Jan 2017

Clinical Trial News and Research

New antibody drug shows promising results to prevent or treat HIV

New method improves speed and diagnostic efficiency during brain surgery

Researcher creates molecular diagnostic system that can quickly identify dangerous bacteria

Yale researchers identify new genetic defect in brain tumor cells that prevents DNA repair

Study paves way for therapies against myeloid-derived suppressor cells that collude with cancer

New approach helps decide better treatment option for laryngeal cancer

Autologous hematopoietic cell transplant may induce sustained remission of multiple sclerosis

Mayo Clinic to test vaccine for providing lifelong immunity against precancerous breast lesions

UTHealth and Children's Memorial Hermann begin two new clinical trials for pediatric brain cancer

Sanford clinical study exploring immunotherapy drug to treat patients with advanced esophageal cancer

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

Researchers discover that existing anti-gout drug can reduce severity of opioid withdrawal symptoms

First-time drug trials launched on basis of flimsy, under-scrutinized evidence, say McGill researchers

Acupuncture improves effectiveness of standard treatment for chronic pain and depression

ALCMI and Scancell collaborate to advance cancer vaccine clinical trials in NSCLC patients

Orthopaedic research helps nurse recover from knee injury

Hemodialysis patients do not wish to receive treatment for depression, study shows

SLATE clinical trial uses Medtronic Visualase MRI-guided laser ablation system to treat common form of epilepsy

Body shaming may contribute to increased health risks

New gene therapy for Pompe disease may replace currently available treatments

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