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AbbVie starts Phase 3 clinical study of atrasentan in patients with diabetic nephropathy

AbbVie announced today the initiation of a Phase 3 clinical study called SONAR (Study Of Diabetic Nephropathy with Atrasentan) to assess the effects of the investigational compound atrasentan - when added to standard of care - on progression of kidney disease in patients with stage 2 to 4 chronic kidney disease and type 2 diabetes.

21 May 2013

New computer model predicts when avian influenza strain becomes infectious

A new computer model could help scientists predict when a particular strain of avian influenza might become infectious from bird to human, according to a report to be published in the International Journal Data Mining and Bioinformatics.

21 May 2013

Scientists design 'fishing' technique to show health benefits of foods

New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells' "superpower" to escape death.

21 May 2013

Researchers pinpoint catalytic trigger for onset of Alzheimer's disease

Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease - when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons in the brain.

21 May 2013

New breakthrough in progeria treatment

Pharmaceuticals that inhibit a specific enzyme may be useful in treating progeria, or accelerated aging in children. A new study performed at the Sahlgrenska Academy, University of Gothenburg, Sweden, indicates that the development of progeria in mice was inhibited upon reducing the production of this enzyme.

21 May 2013

Researchers examine how BRD4 contributes to sustained presence of NF-kappa B in cancer cells

In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.

20 May 2013

Novel medicine for chronic wound treatment

Every 20 seconds, a limb is lost as a consequence of diabetic foot ulcer that does not heal. To date, medical solutions that can change this situation are very limited.

20 May 2013

Purified components of ginger help asthma patients breathe more easily

Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the spicy root also may have properties that help asthma patients breathe more easily.

20 May 2013

Targeting glucagon action: A new frontier for regulating diabetes

For the first time, scientists at the Toronto General Research Institute showed that targeting glucagon action in the brain may be a new frontier for regulating diabetes.

20 May 2013

Joint replacement surgery might be avoidable in the future, suggest scientists

Scientists at Johns Hopkins have turned their view of osteoarthritis inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, they now have evidence that the bone underneath the cartilage is also a key player and exacerbates the damage.

20 May 2013

Non-invasive brain stimulation techniques improve memory

Non-invasive brain stimulation techniques aimed at mental and neurological conditions include transcranial magnetic stimulation for depression, and transcranial direct current (electrical) stimulation, shown to improve memory.

20 May 2013

Research: Women's reproductive function may be tied to their immune status

New research indicates that women's reproductive function may be tied to their immune status. Previous studies have found this association in human males, but not females.

18 May 2013

Wheat Initiative: 60% increase in wheat production needed by 2050

By 2050, a 60% increase in wheat production will be needed to meet the demand of a growing population. The Wheat Initiative, an international consortium gathering public institutions and private companies, was created as part of the 2011 action plan of the G20 Agricultural Ministries to coordinate global wheat research and participate to global food security.

18 May 2013

AGA researchers to present exciting data on GI disorders at DDW 2013

Clinicians, researchers and scientists from around the world will gather for Digestive Disease Week- 2013, the largest and most prestigious gastroenterology meeting, from May 18 to 21, 2013, at the Orange County Convention Center in Orlando, FL.

18 May 2013

Research findings could lead to new therapies for stroke and other brain diseases

Scientists investigating the interaction of a group of proteins in the brain responsible for protecting nerve cells from damage have identified a new target that could increase cell survival.

18 May 2013

UC Davis scientists detect novel molecular target for multiple sclerosis

Working with lab mice models of multiple sclerosis, UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against MS.

17 May 2013

Loss of Merlin protein leads to abnormal growth of tumours

A study led by researchers from Plymouth University Peninsula Schools of Medicine and Dentistry has for the first time revealed how the loss of a particular tumour suppressing protein leads to the abnormal growth of tumours of the brain and nervous system.

17 May 2013

Protein processing breakdown in endoplasmic reticulum

With obesity reaching epidemic levels in some parts of the world, scientists have only begun to understand why it is such a persistent condition. A study in the Journal of Biological Chemistry adds substantially to the story by reporting the discovery of a molecular chain of events in the brains of obese rats that undermined their ability to suppress appetite and to increase calorie burning.

17 May 2013

Northwestern University scientists identify gene important to morning wake-up call

Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.

17 May 2013

Changes in specific proteins contribute to 'leaky-gut' wall

Scientists at Trinity College Dublin have made an important advance in understanding the biological factors that keep the lining of the gut wall intact. Associate Professor, Maria O'Sullivan at Trinity's School of Medicine and St James's Hospital and colleagues, showed that changes in specific proteins may contribute to a 'leaky-gut' wall which may have important implications for common chronic digestive diseases such as irritable bowel syndrome and inflammatory bowel disease.

17 May 2013