Receptor News and Research

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Study explores distribution of new diabetes cases and specialist density in the U.S.

In the last five years, the landscape of type 2 diabetes treatment has changed dramatically. Two new classes of drugs -- SGLT2 inhibitors and GLP-1 receptor agonists -- have been shown to prevent some of the most serious diabetes complications, including heart and kidney conditions, in patients.

25 Oct 2019

Scientists uncover how brain cells respond to and recover from lack of nutrition

We all know that food is essential to healthy development of the brain and body, especially in the earliest stages of life. But exactly how early brain growth is affected by nutrition is not as well understood, especially on a cellular level.

25 Oct 2019

Most popular first-line treatment for hypertension may be less effective than alternative drugs

A new multinational study shows that the most popular first-line treatment for hypertension is less effective and has more side effects than an alternative that's prescribed much less often.

25 Oct 2019

Insights about the sweet receptor could lead to better-tasting food

Whether it's chocolate cake or pasta sauce, the sensation of sweetness plays a major role in the human diet and the perception of other flavors.

24 Oct 2019

Parents' behavior can have substantial impact on developing oxytocin systems in babies

Oxytocin is an extremely important hormone, involved in social interaction and bonding in mammals, including humans.

24 Oct 2019

ConvertibleCAR immunotherapy can be used to attack HIV latent reservoir

A team of Gladstone scientists and their partners at Xyphos Biosciences, Inc. describe a new way of attacking cells infected by HIV in this week's issue of the journal Cell.

24 Oct 2019

Study reveals novel druggable driver gene in human gastrointestinal stromal tumors

Sarcomas - cancers that arise from transformed mesenchymal cells (a type of connective tissue) - are quite deadly. Gastrointestinal stromal tumors are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase.

24 Oct 2019

Researchers discover new details about several proteins implicated in cancer

Researchers from the Stowers Institute for Medical Research have uncovered new details about several proteins implicated in tumor growth and metastasis, opening a potential avenue for the development of treatments for diseases such as breast cancer.

23 Oct 2019

Sanford Burnham Prebys scientist receives $3.58 million to advance treatment for opioid-use disorders

The National Institute on Drug Abuse, part of the National Institutes of Health, awarded a $3.58 million grant to Sanford Burnham Prebys scientist Anthony Pinkerton, Ph.D., to advance a potential treatment for opioid-use disorders, called SBI-553.

23 Oct 2019

Oncolytics Biotech and PrECOG collaborate to study metastatic breast cancer

Oncolytics Biotech Inc. , currently developing pelareorep, an intravenously delivered immuno-oncolytic virus, and PrECOG LLC, a leading cancer research network, today announced their collaboration in which PrECOG will run the BRACELET-1 (PrE0113) study.

22 Oct 2019

High glucose impairs circadian clock function, may increase cardiovascular risk

High glucose in obesity appears to gum up the works of the circadian clocks inside our cells that help regulate the timing of many body functions across the 24-hour day and drive the risk of cardiovascular disease, scientists say.

22 Oct 2019

Columbia researchers capture new detailed images of a temperature-sensing molecule

Columbia University researchers have captured new detailed images of a temperature-sensing molecule in its open, intermediate, and closed states.

21 Oct 2019

Immune cells rewire, repair brain while we sleep, study shows

Science tells us that a lot of good things happen in our brains while we sleep - learning and memories are consolidated and waste is removed, among other things.

21 Oct 2019

SciLifeLab and AstraZeneca establish cryo-EM collaboration to advance biomedicine

The study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signaling complex, the researchers solved the cryo-EM structure of its extracellular region, employing a new approach for data collection.

21 Oct 2019

Blue light and fruit flies: a warning for humans

A new study involving the fruit fly, Drosophila melanogaster, published in the journal npj Aging and Mechanisms of Disease, shows that when flies are kept in darkness, or in white light from which the blue spectrum has been excluded, they live longer, compared to flies kept in alternating 12-hour shifts of blue LED light and darkness. The reason appears to be a speeded-up version of aging; the brain cells, retinal cells and climbing ability, all suffer a breakdown.

18 Oct 2019

Keto diet may cause skin problems

Researchers from Austria have found that ketogenic diets could affect psoriasis-like skin inflammation in mice. They noted that keto diets including medium-chain triglycerides (MCTs) such as coconut along with omega-3 fatty acids obtained from nuts and seeds and fish oil could be a recipe for psoriasis exacerbation. They speculated that this could be true for humans as well. The study titled, “The Influence of Ketogenic Diets on Psoriasiform-Like Skin Inflammation,” was published this week in the Journal of Investigative Dermatology.

17 Oct 2019

Signaling defects could cause congenital heart condition

A congenital heart condition known as left ventricular non-compaction (LVNC) - which occurs when muscly projections in the embryonic heart fail to transform into compact heart muscle - could be caused by signaling defects, according to new preclinical research led by Duke-NUS Medical School in Singapore.

17 Oct 2019

Receptor News and Research

Study explores distribution of new diabetes cases and specialist density in the U.S.

Scientists uncover how brain cells respond to and recover from lack of nutrition

Most popular first-line treatment for hypertension may be less effective than alternative drugs

Insights about the sweet receptor could lead to better-tasting food

Parents' behavior can have substantial impact on developing oxytocin systems in babies

ConvertibleCAR immunotherapy can be used to attack HIV latent reservoir

Study reveals novel druggable driver gene in human gastrointestinal stromal tumors

Researchers discover new details about several proteins implicated in cancer

Sanford Burnham Prebys scientist receives $3.58 million to advance treatment for opioid-use disorders

Oncolytics Biotech and PrECOG collaborate to study metastatic breast cancer

High glucose impairs circadian clock function, may increase cardiovascular risk

Columbia researchers capture new detailed images of a temperature-sensing molecule

Immune cells rewire, repair brain while we sleep, study shows

SciLifeLab and AstraZeneca establish cryo-EM collaboration to advance biomedicine

Blue light and fruit flies: a warning for humans

Keto diet may cause skin problems

Signaling defects could cause congenital heart condition

Rapamycin is more effective at slowing down aging, says researcher

Study underlines the importance of composition of fatty acids in diet

Temple researchers win NIH grant to study HIV-related neuroinflammation in context of opioid addiction

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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