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Children born with CDG don't contain mutation in every cell type, say Sanford-Burnham researchers

Children born with rare, inherited conditions known as Congenital Disorders of Glycosylation, or CDG, have mutations in one of the many enzymes the body uses to decorate its proteins and cells with sugars.

10 May 2013

Progenitor cells remain highly dynamic in the adult brain

By monitoring the behavior of a class of cells in the brains of living mice, neuroscientists at Johns Hopkins discovered that these cells remain highly dynamic in the adult brain, where they transform into cells that insulate nerve fibers and help form scars that aid in tissue repair.

10 May 2013

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.

10 May 2013

Research opens door to new drug therapies for Parkinson's disease

McGill University researchers have unlocked a new door to developing drugs to slow the progression of Parkinson's disease. Collaborating teams led by Dr. Edward A. Fon at the Montreal Neurological Institute and Hospital -The Neuro, and Dr. Kalle Gehring in the Department of Biochemistry at the Faculty of Medicine, have discovered the three-dimensional structure of the protein Parkin.

10 May 2013

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

In cancer, mutations in proteins that control cell growth are common, leading to unrestrained cellular proliferation and tumor formation.

9 May 2013

Trevena, Forest sign collaborative agreement to develop TRV027 for treatment of ADHF

Trevena, Inc., a clinical stage pharmaceutical company and the leader in the discovery and development of G-protein coupled receptor biased ligands, and Forest Laboratories Holding Limited, a subsidiary of Forest Laboratories Inc., an international pharmaceutical company, announced today that they have entered into a collaborative licensing option agreement for the development of TRV027, an AT1R biased-ligand that recently completed Phase 2a clinical trials.

9 May 2013

Researchers discover that microRNAs link two defining characteristics of fit muscles

Researchers discovered that small pieces of genetic material called microRNAs link the two defining characteristics of fit muscles: the ability to burn sugar and fat and the ability to switch between slow- and fast-twitch muscle fibers.

9 May 2013

Thijn Brummelkamp wins 2013 EMBO Gold Medal for genetic analysis of human disease

EMBO today announced Thijn Brummelkamp of the Netherlands Cancer Institute in Amsterdam as the winner of the 2013 EMBO Gold Medal. The award acknowledges his outstanding work to accelerate the genetic analysis of human disease.

9 May 2013

Researchers identify genetic mutations that appear to underlie rare syndrome

Researchers from Massachusetts General Hospital and Duke University have identified genetic mutations that appear to underlie a rare but devastating syndrome combining reproductive failure with cerebellar ataxia - a lack of muscle coordination - and dementia.

9 May 2013

Gene offers new insights into treatment strategies for deep-vein thrombosis

A gene associated with both protection against bacterial infection and excessive blood clotting could offer new insights into treatment strategies for deep-vein thrombosis -- the formation of a harmful clot in a deep vein.

9 May 2013

Missing link between over-stimulation and destruction of brain tissue identified

In many neurodegenerative diseases the neurons of the brain are over-stimulated and this leads to their destruction. After many failed attempts and much scepticism this process was finally shown last year to be a possible basis for treatment in some patients with stroke. But very few targets for drugs to block this process are known.

9 May 2013

UAB exercise and nutrition experts offer tips for summer slim down

With spring in full bloom, many hope to lose pounds before summer's heat descends. University of Alabama at Birmingham exercise and nutrition experts offer tips for those in search of a summer slim down.

9 May 2013

Cannibalistic tadpole may play role in understanding evolution, development of digestive organs

A carnivorous, cannibalistic tadpole may play a role in understanding the evolution and development of digestive organs, according to research from North Carolina State University.

9 May 2013

Phase 1b clinical study data of EBI-005 for treatment of dry eye disease presented at ARVO meeting

Eleven Biotherapeutics, a biopharmaceutical company designing and engineering novel and differentiated protein-based biotherapeutics for ocular diseases, announced today the presentation of data for EBI-005, the first IL-1 (Interleukin-1) signaling inhibitor designed for topical ocular administration, at the Association for Research in Vision and Ophthalmology 2013 Annual Meeting in Seattle, Washington.

9 May 2013

The Avon Foundation awards $275,000 grant to George Washington University

The Avon Foundation announced $275,000 in grants to The George Washington University (GW) School of Medicine and Health Sciences (SMHS) and GW Cancer Institute (GWCI), at the close of the 11th annual Avon Walk for Breast Cancer in Washington, D.C.

8 May 2013

Scientists reexamine gene strongly linked to Alzheimer's disease

Scientists' picture of how a gene strongly linked to Alzheimer's disease harms the brain may have to be revised, researchers at Washington University School of Medicine in St. Louis have found. People with harmful forms of the APOE gene have up to 12 times the risk of developing Alzheimer's disease compared with those who have other variations of the gene.

8 May 2013

New therapeutic targets for reducing heart disease in people with type 1 diabetes

Type 1 (insulin-dependent) diabetes appears to increase the risk of heart disease, the leading cause of death among people with high blood sugar, partly by stimulating the production of calprotectin, a protein that sparks an inflammatory process that fuels the buildup of artery-clogging plaque.

8 May 2013

G Protein News and Research

Children born with CDG don't contain mutation in every cell type, say Sanford-Burnham researchers

Progenitor cells remain highly dynamic in the adult brain

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Research opens door to new drug therapies for Parkinson's disease

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

Trevena, Forest sign collaborative agreement to develop TRV027 for treatment of ADHF

Researchers discover that microRNAs link two defining characteristics of fit muscles

Thijn Brummelkamp wins 2013 EMBO Gold Medal for genetic analysis of human disease

Researchers identify genetic mutations that appear to underlie rare syndrome

Gene offers new insights into treatment strategies for deep-vein thrombosis

Missing link between over-stimulation and destruction of brain tissue identified

UAB exercise and nutrition experts offer tips for summer slim down

Cannibalistic tadpole may play role in understanding evolution, development of digestive organs

Phase 1b clinical study data of EBI-005 for treatment of dry eye disease presented at ARVO meeting

The Avon Foundation awards $275,000 grant to George Washington University

Scientists reexamine gene strongly linked to Alzheimer's disease

New therapeutic targets for reducing heart disease in people with type 1 diabetes

Protein tumor necrosis factor-alpha is a powerful weapon to control cancer

Seven-year quest to understand how breast cancer cells resist treatment

HSPH researchers discover potential target to treat type 2 diabetes and other metabolic diseases

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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