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Study: L-Grb2 has therapeutic efficacy in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

Arcturus and Duke-NUS announce approval of clinical trials for COVID-19 vaccine candidate

Arcturus Therapeutics Holdings Inc., a leading clinical-stage messenger RNA medicines company focused on the discovery, development and commercialization of therapeutics for rare diseases and vaccines, and Duke-NUS Medical School, Singapore's flagship research-intensive graduate entry medical school, today announced that the Clinical Trial Application for COVID-19 vaccine candidate LUNAR-COV19 has been approved to proceed by the Singapore Health Sciences Authority.

22 Jul 2020

Malaria drug does not prevent infection of human lung cells with novel coronavirus

More than 600,000 people worldwide have fallen victim to the lung disease COVID-19 so far, which is caused by the SARS coronavirus-2 (SARS-CoV-2).

22 Jul 2020

Scientists want to know more about using UV light to fight COVID-19 spread

High up near the ceiling, in the dining room of his Seattle-area restaurant, Musa Firat recently installed a “killing zone” — a place where swaths of invisible electromagnetic energy penetrate the air, ready to disarm the coronavirus and other dangerous pathogens that drift upward in tiny, airborne particles.

22 Jul 2020

Study shows chloroquine does not prevent SARS-CoV-2

More than 600,000 people worldwide have fallen victim to the lung disease COVID-19 so far, which is caused by the SARS coronavirus-2 (SARS-CoV-2).

22 Jul 2020

Faster identification and isolation of infected individuals reduce viral transmission

A new analysis of SARS-CoV-2 transmission data in China shows that faster identification and isolation of infected, symptomatic individuals contributed to the shortening of the average serial interval - or the period between the onset of symptoms in successive cases - over time, as fewer opportunities occurred for viral transmission from one infector to more individuals.

22 Jul 2020

Study captures unexpected features of SARS-Cov-2 spike protein

The rod-like spike proteins on the surface of SARS CoV-2 are the tip of the spear of the COVID-19 pandemic.

22 Jul 2020

Self-imposed prevention strategies can help mitigate COVID-19 epidemic

Both self-imposed prevention measures such as hand-washing, mask-wearing and social distancing, as well as government-imposed social distancing can help mitigate and delay a COVID-19 epidemic, according to a new study published this week in PLOS Medicine by Alexandra Teslya of University Medical Center Utrecht, Utrecht, The Netherlands and colleagues.

22 Jul 2020

Researchers identify potential new combination therapy to treat head and neck cancer

Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.

21 Jul 2020

Fusion protein may help treat pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is an insidious disease. Symptoms may begin slowly, and even before they appear, extensive damage has caused the obstruction of small arteries leading to increased blood pressure in the lungs.

21 Jul 2020

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Now, a new study published on the preprint server bioRxiv in July 2020 presents an engineered transgenic mouse that reproduces the functional and clinical characteristics of severe human SARS-CoV-2 infection.

21 Jul 2020

Fasting-mimicking diet along with hormone therapy could help treat breast cancer

A USC-led team of scientists has found that a fasting-mimicking diet combined with hormone therapy has the potential to help treat breast cancer, according to newly published animal studies and small clinical trials in humans.

21 Jul 2020

Nitric oxide treatment can be pivotal in the fight against COVID-19

Nitric oxide treatment can be pivotal in the world's fight against SARS-CoV-2, the coronavirus that causes COVID-19, according to a review from the George Washington University (GW). The article is published in the journal Nitric Oxide.

21 Jul 2020

$65m investment increases British Patient Capital’s exposure to life sciences and health technology

British Patient Capital announces a cornerstone commitment of $65m to SV Health Investors’ latest fund, SV7 Impact Medicine Fund, to turn scientific breakthroughs into biotech companies producing high impact precision medicine drugs for poorly treated diseases.

21 Jul 2020

A multi-omics single cell analysis on COVID-19

Now, a new study published on the preprint server medRxiv aims to analyze the immune response over time, using multi-omics in the study of a single cell.

21 Jul 2020

Doctor in Israel reinfected with COVID-19 three months after recovering

There is still a lot to learn about coronavirus disease (COVID-19), which is currently ravaging across the globe. Though scientists are slowly gaining a better understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is still unclear if being infected once may provide long-lasting immunity against the novel coronavirus.

20 Jul 2020

UC Davis Health evaluates new antibody cocktail as a possible treatment for COVID-19

Timothy Albertson, chair of internal medicine and specialist in pulmonary and critical care, is leading efforts at UC Davis Health to test a new antibody cocktail (REGN-COV2) as a prevention and treatment for COVID-19.

20 Jul 2020

China's Ad5 vectored COVID-19 vaccine safe and induces immune response

A phase 2 trial of an Ad5 vectored COVID-19 vaccine candidate, conducted in China, has found that the vaccine is safe and induces an immune response, according to new research published in The Lancet.

20 Jul 2020

Oxford University and AstraZeneca vaccine against SARS-CoV-2 safe and induces immune response

Promising early stage results from a phase 1/2 clinical trial of the UK's vaccine candidate against SARS-CoV-2 (the virus that causes COVID-19) are published today in The Lancet.

20 Jul 2020

Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

The Josep Carreras Leukaemia Research Institute, a public centre pertaining to the Generalitat de Catalunya's (Government of Catalonia) CERCA network, has created the OneChain Immunotherapeutics spin-off, the aim of which is to develop new immuno-oncological therapeutic tools with various preclinical candidates, based on CAR-T technology for different tumors, such as cortical T-cell acute lymphoblastic leukemia (coT-ALL), a rare subtype of leukemia that mainly affects children, and which has a poor prognosis.

20 Jul 2020

Efficacy News and Research

Study: L-Grb2 has therapeutic efficacy in preclinical models of ovarian and uterine cancer

Arcturus and Duke-NUS announce approval of clinical trials for COVID-19 vaccine candidate

Malaria drug does not prevent infection of human lung cells with novel coronavirus

Scientists want to know more about using UV light to fight COVID-19 spread

Study shows chloroquine does not prevent SARS-CoV-2

Faster identification and isolation of infected individuals reduce viral transmission

Study captures unexpected features of SARS-Cov-2 spike protein

Self-imposed prevention strategies can help mitigate COVID-19 epidemic

Researchers identify potential new combination therapy to treat head and neck cancer

Fusion protein may help treat pulmonary arterial hypertension

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Fasting-mimicking diet along with hormone therapy could help treat breast cancer

Nitric oxide treatment can be pivotal in the fight against COVID-19

$65m investment increases British Patient Capital’s exposure to life sciences and health technology

A multi-omics single cell analysis on COVID-19

Doctor in Israel reinfected with COVID-19 three months after recovering

UC Davis Health evaluates new antibody cocktail as a possible treatment for COVID-19

China's Ad5 vectored COVID-19 vaccine safe and induces immune response

Oxford University and AstraZeneca vaccine against SARS-CoV-2 safe and induces immune response

Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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