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Roskamp Institute Discovers New Target For Drugs To Treat Alzheimer's Disease

Scientists at the Roskamp Institute, a not-for-profit biomedical research facility specializing in Alzheimer's disease research, have isolated a key molecule that gives researchers a new drug target for the treatment of the progressive, irreversible neurological disorder.

28 Oct 2014

Digoxin drug may be adaptable for ALS treatment, study suggests

Digoxin, a medication used in the treatment of heart failure, may be adaptable for the treatment of amyotrophic lateral sclerosis (ALS), a progressive, paralyzing disease, suggests new research at Washington University School of Medicine in St. Louis.

27 Oct 2014

Researchers identify compounds that could lead to discovery of new drugs for African sleeping sickness

In early drug discovery, you need a starting point, says Northeastern University associate professor of chemistry and chemical biology Michael Pollastri.

27 Oct 2014

Salk Institute scientists identify promising target for HIV/AIDS treatment

Like a slumbering dragon, HIV can lay dormant in a person's cells for years, evading medical treatments only to wake up and strike at a later time, quickly replicating itself and destroying the immune system.

27 Oct 2014

Cornell University chemists uncover new insight into the underlying causes of ALS

Using a technique that illuminates subtle changes in individual proteins, chemistry researchers at Cornell University have uncovered new insight into the underlying causes of Amyotrophic Lateral Sclerosis (ALS).

27 Oct 2014

Research could pave way for more effective drugs to treat inflammation

Six Case Western Reserve scientists are part of an international team that has discovered two compounds that show promise in decreasing inflammation associated with diseases such as ulcerative colitis, arthritis and multiple sclerosis.

25 Oct 2014

MIT researchers develop new way to model effects of cancer-causing genetic mutations

Sequencing the genomes of tumor cells has revealed thousands of genetic mutations linked with cancer. However, sifting through this deluge of information to figure out which of these mutations actually drive cancer growth has proven to be a tedious, time-consuming process.

24 Oct 2014

Omeros provides update on OMS824 for treatment of schizophrenia, Huntington's disease

Omeros Corporation today provided an update on OMS824, the company's phosphodiesterase 10 (PDE10) inhibitor in development for the treatment of schizophrenia and Huntington's disease.

21 Oct 2014

Directed Genomics, New England Biolabs to develop new technologies for NGS

New England Biolabs (NEB®) and Directed Genomics together announce that they have established a partnership to develop a suite of new technologies for next generation sequencing (NGS), including target enrichment.

From New England Biolabs 20 Oct 2014

New findings could help develop antibiotics with lower risk of resistance

Scientists have used computer simulations to show how bacteria are able to destroy antibiotics – a breakthrough which will help develop drugs which can effectively tackle infections in the future.

20 Oct 2014

MMP-3 disrupts brain/spinal cord barrier, promotes hemorrhage

Traumatic spinal cord injury (SCI) is a devastating condition with few treatment options. Studies show that damage to the barrier separating blood from the spinal cord can contribute to the neurologic deficits that arise secondary to the initial trauma. Through a series of sophisticated experiments, researchers reporting in The American Journal of Pathology suggest that matrix metalloproteinase-3 (MMP-3) plays a pivotal role in disruption of the brain/spinal cord barrier (BSCB), cell death, and functional deficits after SCI.

20 Oct 2014

TSRI scientists identify long-sought activating molecules for subset of immune system cells

Scientists at The Scripps Research Institute (TSRI) have identified the long-sought activating molecules for a rare but crucial subset of immune system cells that help rally other white blood cells to fight infection.

17 Oct 2014

Researchers receive NIH grant to study mechanisms of auditory hypersensitivity in fragile X syndrome

Fragile X syndrome (FXS) is a genetic disorder in humans that causes social impairments and repetitive behaviors, and other behaviors on the autistic spectrum, as well as cognitive deficits.

17 Oct 2014

Females' natural resistance to bacterial pneumonia is linked to NOS3 enzyme

Researchers have linked increased resistance to bacterial pneumonia in female mice to an enzyme activated by the female sex hormone estrogen.

17 Oct 2014

Scientists map DNA replication process at the most fundamental level

The proteins that drive DNA replication—the force behind cellular growth and reproduction—are some of the most complex machines on Earth.

17 Oct 2014

Cell transplantation treatment may benefit people with spinal cord injury

Two studies recently published in Cell Transplantation reveal that cell transplantation may be an effective treatment for spinal cord injury (SCI), a major cause of disability and paralysis with no current restorative therapies.

16 Oct 2014

SOFIE BIOSCIENCES awarded NCI Phase II SBIR contract to develop [18F]FAC PET

SOFIE BIOSCIENCES, a leader in the field of Positron Emission Tomography (PET) imaging, including probes, scanners, and chemistry systems, announced today that the National Cancer Institute has awarded the company a Phase II Small Business Innovation Research (SBIR) contract for approximately $1.5M over two years.

16 Oct 2014

Reducing heart failure deaths: an interview with Dimitrios Georgiopoulos, UK Medical Director, Novartis

Heart failure is a debilitating, and life-threatening, condition in which the heart cannot pump enough blood around the body. When heart failure continues to progress and worsen over time, the persistent condition is known as chronic heart failure.

From Novartis 16 Oct 2014

Intake of arsenic linked to cardiovascular disease, diabetes

Associated with various types of cancer such as skin and liver, the intake of arsenic it is also linked to cardiovascular disease and diabetes. According to a long-term research conducted by experts from the Center for Research and Advanced Studies it was determined that this metalloid inhibits enzymes associated with antioxidant protection.

16 Oct 2014

SIRT6 protein inhibits liver and colon cancers, but promotes skin cancer caused by ultraviolet light

A new study published in Cancer Research shows SIRT6—a protein known to inhibit the growth of liver and colon cancers—can promote the development of skin cancers by turning on an enzyme that increases inflammation, proliferation and survival of sun-damaged skin cells.

16 Oct 2014

Enzyme News and Research

Roskamp Institute Discovers New Target For Drugs To Treat Alzheimer's Disease

Digoxin drug may be adaptable for ALS treatment, study suggests

Researchers identify compounds that could lead to discovery of new drugs for African sleeping sickness

Salk Institute scientists identify promising target for HIV/AIDS treatment

Cornell University chemists uncover new insight into the underlying causes of ALS

Research could pave way for more effective drugs to treat inflammation

MIT researchers develop new way to model effects of cancer-causing genetic mutations

Omeros provides update on OMS824 for treatment of schizophrenia, Huntington's disease

Directed Genomics, New England Biolabs to develop new technologies for NGS

New findings could help develop antibiotics with lower risk of resistance

MMP-3 disrupts brain/spinal cord barrier, promotes hemorrhage

TSRI scientists identify long-sought activating molecules for subset of immune system cells

Researchers receive NIH grant to study mechanisms of auditory hypersensitivity in fragile X syndrome

Females' natural resistance to bacterial pneumonia is linked to NOS3 enzyme

Scientists map DNA replication process at the most fundamental level

Cell transplantation treatment may benefit people with spinal cord injury

SOFIE BIOSCIENCES awarded NCI Phase II SBIR contract to develop [18F]FAC PET

Reducing heart failure deaths: an interview with Dimitrios Georgiopoulos, UK Medical Director, Novartis

Intake of arsenic linked to cardiovascular disease, diabetes

SIRT6 protein inhibits liver and colon cancers, but promotes skin cancer caused by ultraviolet light

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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