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Study provides new understanding of molecular mechanisms of HPV-induced tumors

The incidence of human papillomavirus (HPV)-associated (HPV+) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and is now more frequently diagnosed than uterine cervical cancer in the United States.

31 Mar 2017

Discovery of new genes linked to Erdheim-Chester disease provides hope for improving diagnoses

National Human Genome Research Institute researchers have identified new genes associated with the Erdheim-Chester disease and some possible new therapies. Findings on this ultra-rare disease, found in approximately 600 people in the world, were published in Blood Advances.

31 Mar 2017

Researchers uncover novel genetic links underlying Fuchs endothelial corneal dystrophy

Corneal diseases are among the most common causes of visual impairment and blindness, with Fuchs endothelial corneal dystrophy (FECD), a gradual swelling and clouding of the cornea, being the most common reason for eventual corneal transplants.

31 Mar 2017

Researchers use stem cells to model different genetic scenarios that underlie neurologic disease

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms.

30 Mar 2017

Scientists uncover how tumor cells can switch disguises to spread easily around the body

Scientists have uncovered how tumor cells in aggressive uterine cancer can switch disguises and spread so quickly to other parts of the body.

30 Mar 2017

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

By engineering an on/off switch into a weakened form of HIV, University of Nebraska-Lincoln researchers have enhanced the safety and effectiveness of a potential vaccine for the virus that has killed approximately 35 million people during the past 35 years.

30 Mar 2017

Researchers shed light on genome reorganization after fertilization in single-cell mammalian embryo

Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single-cell mammalian embryo

30 Mar 2017

Study identifies specific genetic risk factors that increase susceptibility to gliomas

A massive new study involving blood samples from over 30,000 individuals has identified 13 new genetic risk factors for glioma, the most common type of malignant brain tumor in adults

29 Mar 2017

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

Charis Eng, M.D., Ph.D., of Cleveland Clinic and her team have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer. They recently published this discovery in Human Molecular Genetics.

29 Mar 2017

TSRI researchers reveal how viruses incapacitate bacterial defense system

Picture bacteria and viruses locked in an arms race. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas.

28 Mar 2017

JAX professor receives HFSP grant for 3D genome studies of memory, learning and epilepsy

Jackson Laboratory Professor Yijun Ruan, Ph.D., a leader in the study of the three-dimensional organization of the human genome, has received a three-year grant totaling $1,050,000 from the international Human Frontier Science Program to explore the fundamental mechanics involved in memory and learning as well as epilepsy.

28 Mar 2017

Rogue proteins involved in breast cancer point to potential treatment options

For patients with difficult-to-treat cancers, doctors increasingly rely on genomic testing of tumors to identify errors in the DNA that indicate a tumor can be targeted by existing therapies.

28 Mar 2017

High concentrations of stress hormone affect DNA processes and mental health

High concentrations of the stress hormone, Cortisol, in the body affect important DNA processes and increase the risk of long-term psychological consequences.

28 Mar 2017

MIT researchers develop new technique for early liver cancer diagnosis

In many parts of the world, including Southeast Asia and sub-Saharan Africa, exposure to a fungal product called aflatoxin is believed to cause up to 80 percent of liver cancer cases. This fungus is often found in corn, peanuts, and other crops that are dietary staples in those regions.

28 Mar 2017

Study shows how epigenetic randomness helps cancer cells proliferate

In a research effort that merged genetics, physics and information theory, a team at the schools of medicine and engineering at The Johns Hopkins University has added significantly to evidence that large regions of the human genome have built-in variability in reversible epigenetic modifications made to their DNA.

27 Mar 2017

New UBC research reveals clues to how bacteria proliferates in lungs of cystic fibrosis patients

New UBC research on bacteria that cause major problems for those with cystic fibrosis reveals clues as to how it proliferates for so long in the lungs and offers new ideas for treatments to explore.

27 Mar 2017

New genetic test may give men better view on how to deal with prostate cancer risk

Scientists are reporting a test which can predict which patients are most at risk from aggressive prostate cancer, and whether they suffer an increased chance of treatment failure.

27 Mar 2017

Scientists call for better basic-clinical genomic research collaborations

In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory, National Human Genome Research Institute and institutions across the U.S. declare in a Leading Edge commentary in Cell.

27 Mar 2017

Study shows how antibiotics increase survival chances of bacteria

Antibiotics harm bacteria and stress them. Trimethoprim (TMP), an antibiotic, inhibits the growth of the bacterium Escherichia coli and induces a stress response.

25 Mar 2017

Researchers report discovery of new gene linked to Tau accumulation in AD

Tau pathology is one of the defining features of Alzheimer disease (AD), which is the most common form of dementia in older age.

25 Mar 2017

Genome News and Research

Study provides new understanding of molecular mechanisms of HPV-induced tumors

Discovery of new genes linked to Erdheim-Chester disease provides hope for improving diagnoses

Researchers uncover novel genetic links underlying Fuchs endothelial corneal dystrophy

Researchers use stem cells to model different genetic scenarios that underlie neurologic disease

Scientists uncover how tumor cells can switch disguises to spread easily around the body

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

Researchers shed light on genome reorganization after fertilization in single-cell mammalian embryo

Study identifies specific genetic risk factors that increase susceptibility to gliomas

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

TSRI researchers reveal how viruses incapacitate bacterial defense system

JAX professor receives HFSP grant for 3D genome studies of memory, learning and epilepsy

Rogue proteins involved in breast cancer point to potential treatment options

High concentrations of stress hormone affect DNA processes and mental health

MIT researchers develop new technique for early liver cancer diagnosis

Study shows how epigenetic randomness helps cancer cells proliferate

New UBC research reveals clues to how bacteria proliferates in lungs of cystic fibrosis patients

New genetic test may give men better view on how to deal with prostate cancer risk

Scientists call for better basic-clinical genomic research collaborations

Study shows how antibiotics increase survival chances of bacteria

Researchers report discovery of new gene linked to Tau accumulation in AD

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