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Studies reveal how popular drug helps in heart failure

Results were released today from the first two clinical studies designed specifically to examine the effects of the heart drug sacubitril/valsartan on the structure and function of the failing heart.

3 Sep 2019

Discovery may help identify signs of type 1 diabetes earlier

A new study showed that there are significant differences in the MHC class II antigens on the insulin peptide that is deficient in type 1 diabetes mellitus (T1DM). These determine the response of the T cells to the insulin peptide that causes destruction of insulin.

2 Sep 2019

ARNI therapy trial misses target in heart failure, may have selective benefit only

Heart failure with preserved ejection fraction (HFpEF) is a common condition, affecting millions of people and resulting in significant illness and death. No effective treatments have been developed for this condition.

2 Sep 2019

Discovery of second gene responsible natural short-sleep

Sleep is a crucial part of human health. Piling up a chronic sleep debt by consistently sleeping less than is needed for a fully rested feeling causes a number of illnesses, including heart disease, cancer and autoimmune conditions.

1 Sep 2019

Danish-American researchers find new way to treat chronic inflammation

Researchers from Aarhus University Hospital and Aarhus University in Denmark in collaboration with researchers from Colorado in the United States have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma and HIV.

30 Aug 2019

Nerve cells aid in the spread of pancreatic cancer, study reveals

A couple of molecules that nerve cells use to grow during development could help explain why the most common pancreatic cancers are so difficult to contain and for patients to survive, a new study led by Johns Hopkins Kimmel Cancer Center researchers suggests.

30 Aug 2019

A detailed map to understand how viruses infect human cells

Biologists at Columbia University Vagelos College of Physicians and Surgeons have leveraged a computational method to map protein-protein interactions between all known human-infecting viruses and the cells they infect.

29 Aug 2019

A single cholesterol-derived molecule promotes adiposity

A single cholesterol-derived molecule, called 27-hydroxycholesterol (27HC), lurks inside your bloodstream and will increase your body fat, even if you don't eat a diet filled with red meat and fried food. That kind of diet, however, will increase the levels of 27HC and body weight.

29 Aug 2019

Investigational drug reduces stuttering symptoms in open-label pilot study

A team led by a psychiatrist at the University of California, Riverside, has tested the orally administered investigational medication ecopipam on adults who stutter in an open-label, uncontrolled clinical trial and found that it reduced their stuttering symptoms from the start of therapy after eight weeks of dosing.

28 Aug 2019

UC San Francisco scientists identify second 'short sleep' gene after 10-year search

After a decade of searching, the UC San Francisco scientists who identified the only human gene known to promote "natural short sleep" -- lifelong, nightly sleep that lasts just four to six hours yet leaves individuals feeling fully rested -- have discovered a second.

28 Aug 2019

Maternal high-fat diet may slow learning ability in offspring, study suggests

In a bid to further explore how a mother-to-be's diet might affect her offspring's brain health, Johns Hopkins Medicine researchers have found that pregnant and nursing rats fed high fat diets have offspring that grow up to be slower than expected learners and that have persistently abnormal levels of the components needed for healthy brain development and metabolism.

From Johns Hopkins Medicine 28 Aug 2019

Nab-Paclitaxel drug combo reduces risk of breast cancer recurrence

A recent large German study has shown that a new combination therapy for breast cancer treatment leads to a lowered risk of the disease coming back. A commentary on this landmark clinical trial has been published in the latest issue of the Journal of Clinical Oncology by the researchers Masey Ross and Charles Geyer Jr. from the VCU Massey Cancer Center. The commentary was titled, “Nab-Paclitaxel: A New Standard of Care in Neoadjuvant Therapy of High-Risk Early Breast Cancer?”

27 Aug 2019

U of T scientists create antibodies with enormous potential for regenerative medicine

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

27 Aug 2019

Researchers find diverse immune cell profiles, roles in breast cancer resistance to immunotherapy

In recent years it has been increasingly appreciated that immune cells within the tumor microenvironment contribute to tumor progression and, importantly, to the tumor's response to therapy.

27 Aug 2019

Remodeling unhealthful gut microbiomes with the help of synthetic peptides

You are what you eat - right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer.

27 Aug 2019

Polycystic kidney disease may be preventable

Kidney failure is a lifelong burden in hundreds of thousands of people who need to be treated either by dialysis or a kidney transplant. Both procedures significantly increase the cost of healthcare and reduce the quality of life.

26 Aug 2019

Yale-led study reveals new factors that contribute to hardening of arteries and plaque growth

In a new Yale-led study, investigators have revealed previously unknown factors that contribute to the hardening of arteries and plaque growth, which cause heart disease.

26 Aug 2019

Smoking simulator captures synthetic cannabinoid combustion products

Researchers have developed a smoking simulator that enables the reliable detection of the combustion products formed when synthetic cannabinoids are smoked.

26 Aug 2019

Researchers target cancer's protective barrier

Cancer cells are notorious for their camouflage work, which enables them to escape immune targeting. Now scientists are learning how to strip away the disguise and allow the immune system to do its work, by targeting cells called myeloid-derived suppressor cells (MDSCs) that shield the tumor. This would also enhance the effectiveness of newer cancer immunotherapies like Chimeric-Antigen Receptor T cell (CAR-T).

26 Aug 2019