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Combination approach is safe, improves survival outcomes in a subset of glioblastoma patients

Intratumoral delivery of an engineered oncolytic virus (DNX-2401) targeting glioblastoma (GBM) cells combined with subsequent immunotherapy was safe and improved survival outcomes in a subset of patients with recurrent GBM, according to results from a multi-institutional Phase I/II clinical trial co-led by researchers at The University of Texas MD Anderson Cancer Center and the University of Toronto.

15 May 2023

Study offers new insights into how toxic proteins spread in the brains of people with Alzheimer's disease

Fresh insights into the spread of damaging proteins that build up in the brains of people with Alzheimer's disease could hold the key to stopping the condition progressing, a study says.

15 May 2023

Metabolically healthy and unhealthy 'forms' of obesity linked with increased risk of obesity-related cancers

New research to be presented at this coming week's European Congress on Obesity in Dublin, Ireland (17-20 May) and published in the Journal of the National Cancer Institute shows that both the metabolically healthy and unhealthy 'forms' of obesity are associated with an increased risk of various obesity-related cancers, with the relationship stronger in metabolically unhealthy obesity.

15 May 2023

Study sheds light on the importance of a subset of microglial cells in cognition and memory

A new study sheds light on the importance of microglia, the immune cells of the brain, in cognition and memory.

15 May 2023

Exploiting platelets for antitumor drug delivery and immune modulation of tumor microenvironment

Announcing a new publication for Acta Materia Medica journal. Platelets are blood components traditionally believed to have fundamental roles in vascular hemostasis and thrombosis.

15 May 2023

Brain cancer cells communicate with astrocytes to enhance tumor growth by energy transfer

Malignant brain tumors belong to a group of cancers with bleak prognosis. These tumors are resistant to treatment and considered incurable.

15 May 2023

Humanized mouse model for rare genetic disease developed for the first time

Mice with a defected human gene responsible for a rare genetic disease, called congenital adrenal hyperplasia, have been developed for the first time.

15 May 2023

Nanoparticles take aim at COVID-19 with lysosome-targeted delivery

Researchers discuss the use of endo-lysosome-targeted nanoparticles for delivering antiviral therapy to treat coronavirus infections.

15 May 2023

SARS-CoV-2 variants show altered glycan processing

Researchers examine spike-protein trimers from SARS-CoV-2 variants to compare the N (asparagine)-glycan landscape.

15 May 2023

Deep generative models to generate hypothetical SARS-CoV-2 spike sequences

Scientists explore the use of deep generative models in producing complete instances of as-yet undiscovered SARS-CoV2 Spike protein sequences. The resulting models substantially outperform a state-of-the-art generative model for protein sequences finetuned on SARS-CoV2 data.

14 May 2023

Swiss researchers identify plastic-degrading microbial strains in the Alps and Arctic region

Finding, cultivating, and bioengineering organisms that can digest plastic not only aids in the removal of pollution, but is now also big business.

13 May 2023

Drug combination can prolong survival and improve quality of life in patients with advanced lung cancer

A recent clinical trial showed that the drug combination of cemiplimab plus platinum chemotherapy can prolong survival in patients with advanced lung cancer when compared with placebo plus platinum chemotherapy. Now an analysis published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society, indicates that cemiplimab plus platinum chemotherapy also affects quality of life compared to chemotherapy alone.

13 May 2023

Newly identified biomarker may predict NSCLC patients' treatment response to chemoimmunotherapy

Cutting-edge cancer treatments like immunotherapy are offering new hope for patients, often in combination with more common approaches such as chemotherapy. But determining the best treatment combination isn't always straightforward.

12 May 2023

Patient-derived head and neck cancer organoids could aid the discovery of novel therapies

Researchers from the Organoid group (Hubrecht Institute) and UMC Utrecht have developed a biobank with organoids derived from patients with head and neck cancer (HNC).

12 May 2023

Using an intracellular toolkit to map organelle bio-geography in stem cells

Organelles – the bits and pieces of RNA and protein within a cell – play important roles in human health and disease, such as maintaining homeostasis, regulating growth and aging, and generating energy.

12 May 2023

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Researchers conducted a phase I clinical trial of a personalized mRNA neoantigen vaccine.

12 May 2023

Young Geneva researcher wins SAKK Trial Network Award for clinical research on lymphoma

A young researcher from the Geneva University Hospital (HUG) and the University of Geneva (UNIGE), Dr Noémie Lang, wins the prestigious Swiss Group for Clinical Cancer Research (SAKK) Trial Network Award, with the intent to carry out a study evaluating early detection of central nervous system involvement in lymphomas.

12 May 2023

B Cell News and Research

Combination approach is safe, improves survival outcomes in a subset of glioblastoma patients

Study offers new insights into how toxic proteins spread in the brains of people with Alzheimer's disease

Metabolically healthy and unhealthy 'forms' of obesity linked with increased risk of obesity-related cancers

Study sheds light on the importance of a subset of microglial cells in cognition and memory

Exploiting platelets for antitumor drug delivery and immune modulation of tumor microenvironment

Brain cancer cells communicate with astrocytes to enhance tumor growth by energy transfer

Humanized mouse model for rare genetic disease developed for the first time

Nanoparticles take aim at COVID-19 with lysosome-targeted delivery

SARS-CoV-2 variants show altered glycan processing

Deep generative models to generate hypothetical SARS-CoV-2 spike sequences

Swiss researchers identify plastic-degrading microbial strains in the Alps and Arctic region

Drug combination can prolong survival and improve quality of life in patients with advanced lung cancer

Newly identified biomarker may predict NSCLC patients' treatment response to chemoimmunotherapy

Patient-derived head and neck cancer organoids could aid the discovery of novel therapies

Using an intracellular toolkit to map organelle bio-geography in stem cells

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Young Geneva researcher wins SAKK Trial Network Award for clinical research on lymphoma

Study identifies extremely potent monoclonal antibodies that neutralized multiple sarbecoviruses

Vector Biolabs expands viral vector manufacturing capacity and adds to QC capabilities

A machine-learning approach for the early diagnosis of Parkinson's disease

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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