Genes News and Research

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Tumor suppressor gene represses 'jumping genes'

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or "jumping genes," from hopping around the human genome.

29 Oct 2020

Severe ulcerative colitis linked to a newly-discovered strain of oral bacteria

Bacteria from the mouth could hold clues to understanding – and potentially treating – severe ulcerative colitis, a painful bowel disease.

29 Oct 2020

High dose radiation therapy linked to shorter survival times in NSCLC patients

A genetic analysis of non-small cell lung cancer (NSCLC) patients on the phase III NRG Oncology RTOG 0617 clinical trial assessing radiation dose discovered that high dose radiation therapy is associated with shorter survival times among patients with a radiation-sensitive genotype in DNA repair pathway.

29 Oct 2020

Cell biologists and bioimaging expert team up to solve fourth dimension secrets

Cell biologists at the University of Illinois at Urbana-Champaign and Bar-Ilan University at Israel and a bioimaging expert at the University of Central Florida are teaming up in what they hope may lead to a major breakthrough in understanding of the three-dimensional organization of the nucleus over time and their role in certain diseases.

29 Oct 2020

Study reveals complex and vast diversity of African genetic variation

The study, in which six Wits researchers were involved, show that these newly discovered variants were found mostly among newly sampled ethnolinguistic groups.

29 Oct 2020

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

By leveraging nucleotide triphosphate analog-induced cell death, Chinese researchers unveiled genes that affect the import, export, and metabolism of pervasively used antiviral drugs in the treatment of coronavirus disease (COVID-19). This exciting study is currently available on the bioRxiv* preprint server.

28 Oct 2020

Cognitive disorders associated with risk for developing severe COVID-19

Dementia and other cognitive disorders now appear to be risk factors for developing severe COVID-19, according to research from the University of Georgia. The findings highlight the need for special care for populations with these preexisting conditions during the pandemic.

28 Oct 2020

Grant programs will provide $2.2 million to support biomedical research on healthy aging

The Glenn Foundation for Medical Research and the American Federation for Aging Research announce the 2020 recipients of three grant programs: the Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty, the Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research, and the Glenn Foundation for Medical Research Breakthroughs in Gerontology Awards.

28 Oct 2020

Penn researchers awarded $5.4 million to find genetic risk markers for testicular cancer

The international hunt to find more genetic risk markers for testicular cancer is expanding. A team of researchers led by Katherine L. Nathanson, MD, deputy director of the Abramson Cancer Center and the Pearl Basser Professor for BRCA-Related Research in the Perelman School of Medicine at the University of Pennsylvania, was recently awarded $5.4 million over five years from the National Institutes of Health to continue the long-standing genomics work of the TEsticular CAncer Consortium (TECAC).

28 Oct 2020

Genetic alterations linked to high incidence of prostate cancer in African American men

Prostate cancer tumors from African American men had higher frequencies of certain genetic alterations that may be associated with aggressive disease, compared with prostate cancer tumors from white men.

28 Oct 2020

Researchers describe factors that reduce placenta's capacity to protect fetus from zika virus

Genetic factors that reduce the placenta's capacity to protect the fetus from the zika virus are described by Brazilian researchers in an article published in PLOS Neglected Tropical Diseases.

28 Oct 2020

Scientists use experimental approach to identify genes and interactions

A phage is a virus that invades a bacterial cell. While harmless to human cells, phages are potentially deadly to bacteria since many phages enter a cell in order to hijack its machinery in order to reproduce itself, thus destroying the cell.

28 Oct 2020

Genetic analysis with RNA sequencing can increase diagnostic yield, shows study

In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis. A recent addition to the toolkit, RNA sequencing, has been demonstrated to help researchers narrow down disease candidate variants identified first on exome and genome sequencing.

28 Oct 2020

Specific genes of infant gut bacterium determine its symbiotic function in the infant's gut

While an infant's genes distinguish her from other newborns, a new peer-reviewed study reports that specific genes of a particular infant gut bacterium determine its symbiotic function in the infant's gut.

28 Oct 2020

Study: Coronaviruses are adept at imitating human immune proteins involved in COVID-19

Coronaviruses are adept at imitating human immune proteins that have been implicated in severe COVID-19 disease, a study from researchers at Columbia University Vagelos College of Physicians and Surgeons has found.

28 Oct 2020

Gut's immune response to SARS-CoV-2 very different from the lung

Megan L. Stanifer et al. study the immune response in the human gut upon SARS-CoV-2 infection. The study published as a bioRxiv* preprint reveals a robust proinflammatory response: a cell type-specific or a tissue-specific regulation of interferon-mediated signaling during SARS-CoV-2 infection.

27 Oct 2020

Inflammasome may play a key role in triggering immune response to cancer

The inflammasome — a protein signaling network that is activated to rid the body of virus or bacteria-infected cells — may play an important role in triggering an immune response to cancer and causing an existing class of drugs to work better against cancers.

27 Oct 2020

Scripps Research scientists uncover potential new strategy for treating eye diseases

Scientists at Scripps Research have uncovered a potential new strategy for treating eye diseases that affect millions of people around the world, often resulting in blindness.

27 Oct 2020

Scientists uncover surprising players in acute liver failure

Acute liver failure is a devastating, rapidly progressing disease that results in death in 80% of cases, unless an emergency liver transplant is performed. In the developed world, its leading cause is a substantial overdose of acetaminophen, also known as paracetamol.

27 Oct 2020

Study shows how a genetic mutation causes common sleep syndrome

A new study by researchers at UC Santa Cruz shows how a genetic mutation throws off the timing of the biological clock, causing a common sleep syndrome called delayed sleep phase disorder.

27 Oct 2020

Genes News and Research

Tumor suppressor gene represses 'jumping genes'

Severe ulcerative colitis linked to a newly-discovered strain of oral bacteria

High dose radiation therapy linked to shorter survival times in NSCLC patients

Cell biologists and bioimaging expert team up to solve fourth dimension secrets

Study reveals complex and vast diversity of African genetic variation

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

Cognitive disorders associated with risk for developing severe COVID-19

Grant programs will provide $2.2 million to support biomedical research on healthy aging

Penn researchers awarded $5.4 million to find genetic risk markers for testicular cancer

Genetic alterations linked to high incidence of prostate cancer in African American men

Researchers describe factors that reduce placenta's capacity to protect fetus from zika virus

Scientists use experimental approach to identify genes and interactions

Genetic analysis with RNA sequencing can increase diagnostic yield, shows study

Specific genes of infant gut bacterium determine its symbiotic function in the infant's gut

Study: Coronaviruses are adept at imitating human immune proteins involved in COVID-19

Gut's immune response to SARS-CoV-2 very different from the lung

Inflammasome may play a key role in triggering immune response to cancer

Scripps Research scientists uncover potential new strategy for treating eye diseases

Scientists uncover surprising players in acute liver failure

Study shows how a genetic mutation causes common sleep syndrome

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