Clinical Trial News and Research

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Mesh used to reinforce hernia repair provides mixed outcomes, study finds

Among patients undergoing incisional hernia repair, the use of mesh to reinforce the repair was associated with a lower risk of hernia recurrence over 5 years compared with when mesh was not used, although with long-term follow-up, the benefits attributable to mesh were offset in part by mesh-related complications, according to a study published online by JAMA.

18 Oct 2016

Clinical study reveals safety and efficacy of novel investigational colonoscopy prep

Detailed results from a Phase 2 study of a novel colonoscopy prep (ECP) under development by ColonaryConcepts, LLC show the investigational treatment to be at least as effective and safe as two currently available colonoscopy prep formulations, while offering a much higher level of patient satisfaction and preference than standard preps.

17 Oct 2016

Moderate calcium intake not linked to coronary artery calcification, says UAB cardiologist

A study recently published in the Journal of the American Heart Association is prompting headlines like "Calcium supplements might hurt your heart."

17 Oct 2016

New clinical study to examine safety and outcomes of body cooling in cardiac arrest patients

The R Adams Cowley Shock Trauma Center at the University of Maryland has opened a clinical trial to study whether rapidly cooling the body temperature of patients whose hearts stop due to massive blood loss will give surgeons extra time to find and repair injuries, and in turn, help save their lives.

17 Oct 2016

NAC improves effectiveness of adoptive cell therapy for treating melanoma

A collaborative team of investigators at the Medical University of South Carolina and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma. These findings were reported in the October 15, 2016 issue of Cancer Research.

17 Oct 2016

Researchers develop MRI-based method that can track progression of genetically mutated gliomas

UT Southwestern Medical Center researchers have developed an MRI-based method that can track the state and progression of a common type of genetically mutated brain cancer.

17 Oct 2016

Scientists at NIH and Emory University induce sustained remission in SIV-infected monkeys

Scientists at the National Institutes of Health and Emory University have experimentally induced sustained remission of SIV, the simian form of HIV, in infected monkeys.

14 Oct 2016

Encapsulated cell therapy could be new way to fight glaucoma

An experimental drug, consisting of cells manufactured and implanted in the eye to stimulate optic nerve growth and activity, could be an entirely new way of fighting glaucoma, according to BrightFocus Foundation.

14 Oct 2016

CTA tests motivate people with suspected coronary artery disease to adopt healthier lifestyle practices

UCLA researchers have found that undergoing a computer tomographic angiography was a better motivator to get people with suspected coronary artery disease to adopt healthier lifestyle practices than an exercise electrocardiography and stress test.

14 Oct 2016

UA study questions safety and efficacy of selenium in reducing risk of colorectal cancer

A 12-year study led by a team of University of Arizona Cancer Center researchers is bringing into question the safety and efficacy of selenium, a popular nutritional supplement touted to combat and reduce the risk of colorectal cancer.

14 Oct 2016

TSRI scientists receive NIH grant to develop memory-erasing medication for addiction

In a development that brings the world one step closer to a time when destructive addiction-fueling memories can be erased with a single treatment, scientists from the Florida campus of The Scripps Research Institute have been given a grant by the National Institutes of Health through the Blueprint Neurotherapeutics Network and the National Institute of Drug Abuse.

13 Oct 2016

Mount Sinai awarded $10 million grant to explore cellular, molecular mechanisms of GVHD

Researchers from the Icahn School of Medicine at Mount Sinai have been awarded a $10 million from the National Cancer Institute to explore the cellular and molecular mechanisms of acute graft-versus-host disease (GVHD), a common side effect that occurs after allogeneic bone marrow transplantation (BMT), and to develop novel therapeutic strategies for BMT patients with cancer that begin in the cells of blood-forming tissue or hematologic malignancies.

13 Oct 2016

UIC researchers receive grant to study impact of diagnostic error on outcomes for pulmonary patients

Researchers at the University of Illinois at Chicago have been awarded a $1.5 million grant from the Agency for Healthcare Research and Quality to study the impact of diagnostic error on outcomes for pulmonary patients and the use of lung-function testing in primary care.

13 Oct 2016

CarThera receives €5.7 million grant for DOME project from France’s Investments for the Future Program

CarThera, which designs and develops innovative medical devices to treat brain disorders, today announces it has received a grant of €5.7 million ($6.4m) for its DOME project.

13 Oct 2016

Clinical study to determine safety, efficacy of allogeneic CDCs for patients with myocardial infarction

A multi-center team of researchers are planning a clinical trial using cardiosphere-derived cells (CDCs) (a heterogeneous cluster of proliferating cardiac cells that include mesenchymal stem cells) to regenerate the tissue and improve function of the heart in patients who have suffered heart attacks (myocardial infarction, MI).

13 Oct 2016

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients.

12 Oct 2016

Clinical trial finds women with heavy periods can be greatly helped by GP-prescribed treatments

The largest and longest running clinical trial of medical therapies for heavy periods has found that women can be greatly helped by having treatments just from their GP, with most avoiding hospital operations.

12 Oct 2016

Financial difficulties may impact treatment outcomes for cancer patients

Financial difficulties can significantly impact a cancer patient's quality of life during treatment and may even increase their risk of death, according to the results of a pooled analysis presented at the ESMO 2016 Congress in Copenhagen.

12 Oct 2016

Study to examine efficacy of orally administered medication in treating stuttering

Stuttering, an interruption in the flow of speech, affects about three million Americans. It begins most often in childhood, affecting four men for every woman. A precise cause of this complex communicative disorder is not known.

8 Oct 2016

New study of Phase II Alzheimer's drug pipeline reveals more ways to combat disease

A new analysis of the Phase II Alzheimer's drug pipeline, conducted by ResearchersAgainstAlzheimer's, revealed 57 new Alzheimer's drugs. According to the analysis, nearly twice as many mechanisms of action are being tested in Phase II than in Phase III clinical trials.

7 Oct 2016

Clinical Trial News and Research

Mesh used to reinforce hernia repair provides mixed outcomes, study finds

Clinical study reveals safety and efficacy of novel investigational colonoscopy prep

Moderate calcium intake not linked to coronary artery calcification, says UAB cardiologist

New clinical study to examine safety and outcomes of body cooling in cardiac arrest patients

NAC improves effectiveness of adoptive cell therapy for treating melanoma

Researchers develop MRI-based method that can track progression of genetically mutated gliomas

Scientists at NIH and Emory University induce sustained remission in SIV-infected monkeys

Encapsulated cell therapy could be new way to fight glaucoma

CTA tests motivate people with suspected coronary artery disease to adopt healthier lifestyle practices

UA study questions safety and efficacy of selenium in reducing risk of colorectal cancer

TSRI scientists receive NIH grant to develop memory-erasing medication for addiction

Mount Sinai awarded $10 million grant to explore cellular, molecular mechanisms of GVHD

UIC researchers receive grant to study impact of diagnostic error on outcomes for pulmonary patients

CarThera receives €5.7 million grant for DOME project from France’s Investments for the Future Program

Clinical study to determine safety, efficacy of allogeneic CDCs for patients with myocardial infarction

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

Clinical trial finds women with heavy periods can be greatly helped by GP-prescribed treatments

Financial difficulties may impact treatment outcomes for cancer patients

Study to examine efficacy of orally administered medication in treating stuttering

New study of Phase II Alzheimer's drug pipeline reveals more ways to combat disease

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