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Scientists aim to understand how mitochondrial defects lead to pathological states

Mitochondrial dysfunction is the root cause of many diseases that are bewildering in their variety and complexity. They include rare genetic disorders in children, some forms of heart disease, and most likely many cases of Parkinson's disease.

26 Jan 2017

TSRI researchers develop first stable semisynthetic single-celled organism

Life’s genetic code has only ever contained four natural bases. These bases pair up to form two “base pairs”—the rungs of the DNA ladder—and they have simply been rearranged to create bacteria and butterflies, penguins and people. Four bases make up all life as we know it.

25 Jan 2017

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Maternal infection during pregnancy increases the risk for psychiatric disorders in the child, but the path between the two is something of a mystery.

25 Jan 2017

Nicotine normalizes genetically-induced brain impairments linked to schizophrenia

A steady stream of nicotine normalizes genetically-induced impairments in brain activity associated with schizophrenia, according to new research involving the University of Colorado Boulder.

24 Jan 2017

Researchers discover mutation hotspots that act like backseat drivers for breast cancer development

Researchers at the Wellcome Trust Sanger Institute have discovered 'hotspots' of mutations in breast cancer genomes, where mutations thought to be inactive 'passengers' in the genome have now been shown to possibly drive further cancerous changes.

23 Jan 2017

Characterizing the Brain - Cell by Cell

My group develops approaches to study cell-to-cell signaling in the brain – how the cells of the brain talk to each other. The brain is heterogeneous, probably more so than any other organ in our body, and many of its functions depend on the unique characteristics of these cells.

From Pittcon 23 Jan 2017

Sapientia genome analysis software by Congenica could cut costs and save lives

Whole genome analysis (WGA) enables rapid diagnosis of rare disease, ensuring that an appropriate course of management and treatment can be administered, possibly within days for acute neonatal cases, cutting the cost of intensive care and potentially saving lives. Rapid diagnosis is one of the many benefits of using the Sapientia™ genome analysis and interpretation platform that Dr Nick Lench, Chief Operating Officer of Congenica, will be discussing at Precision Medicine World Conference (PMWC) 2017 on January 23rd at 3.15pm.

23 Jan 2017

Researchers uncover mechanism of resistance used by triple negative breast cancer

Breast cancer cells are evasive, finding ways to bypass drugs designed to stop their unchecked growth.

20 Jan 2017

Researchers generate structural models for protein families with metagenomic sequences

For proteins, appearance matters. These important molecules largely form a cell's structures and carry out its functions: proteins control growth and influence mobility, serve as catalysts, and transport or store other molecules.

20 Jan 2017

FishTaco method pinpoints bacterial species responsible for each functional imbalance in microbiome

A growing body of evidence indicates that the trillions of microbes that live on and inside our bodies affect our health. Collectively, these resident microbes form our microbiome.

20 Jan 2017

TSRI scientists develop new method to enhance drug discovery and protein research

A team led by scientists at The Scripps Research Institute (TSRI) has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins.

20 Jan 2017

CeMM scientists develop new method by integrating CRISPR genome editing with single-cell sequencing

Genome editing using CRISPR/Cas9 "gene scissors" is a powerful tool for biological discovery and for identifying novel drug targets.

19 Jan 2017

Scientists identify 'molecular barcode' in blood samples that can predict survival of Ebola patients

Scientists have identified a 'molecular barcode' in the blood of patients with Ebola virus disease that can predict whether they are likely to survive or die from the viral infection.

19 Jan 2017

New research provides insight into how estrogen modulates fear learning

Low estrogen levels may make women more susceptible to the development of post-traumatic stress disorder (PTSD) at some points in their menstrual cycles or lifetimes, while high estrogen levels may be protective.

19 Jan 2017

Researchers explore ins and outs of genome sequencing in newborns

When you have a baby, a nurse or a phlebotomist performs a heel stick to take a few drops of blood from your infant and sends it off to a state lab for a battery of tests.

19 Jan 2017

Researcher awarded $1.8 million grant to explore how chronic stress impacts cancer development

A five-year, $1.8 million grant (R01CA203965) from the National Cancer Institute awarded to Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, will support research to further elucidate the mechanisms behind the most frequently mutated gene in human tumors - p53.

19 Jan 2017

Research finding provides new target for regulating cell division

Modern genome sequencing methods used to measure the efficiency of synthesis of individual protein during cell division has found that the enzymes that make lipids and membranes were synthesized at much greater efficiency when a cell is ready to split.

19 Jan 2017

New ‘5-D fingerprint’ technique could precisely measure properties of individual protein molecules

In research that could one day lead to advances against neurodegenerative diseases like Alzheimer's and Parkinson's, University of Michigan engineering researchers have demonstrated a technique for precisely measuring the properties of individual protein molecules floating in a liquid.

18 Jan 2017

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

An enzyme identified in Saccharomyces cerevisiae, commonly known as brewer's or baker's yeast, has passed in vitro trials, demonstrating its capacity to kill acute lymphoblastic leukemia (ALL) cells.

18 Jan 2017

Study finds link between obesity-related disease and epigenetic modifications

Obesity has been linked to "letter" changes at many different sites in the genome, yet these differences do not fully explain the variation in people's body mass index (BMI) or why some overweight people develop health complications while others don't.

18 Jan 2017

Genome News and Research

Scientists aim to understand how mitochondrial defects lead to pathological states

TSRI researchers develop first stable semisynthetic single-celled organism

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Nicotine normalizes genetically-induced brain impairments linked to schizophrenia

Researchers discover mutation hotspots that act like backseat drivers for breast cancer development

Characterizing the Brain - Cell by Cell

Sapientia genome analysis software by Congenica could cut costs and save lives

Researchers uncover mechanism of resistance used by triple negative breast cancer

Researchers generate structural models for protein families with metagenomic sequences

FishTaco method pinpoints bacterial species responsible for each functional imbalance in microbiome

TSRI scientists develop new method to enhance drug discovery and protein research

CeMM scientists develop new method by integrating CRISPR genome editing with single-cell sequencing

Scientists identify 'molecular barcode' in blood samples that can predict survival of Ebola patients

New research provides insight into how estrogen modulates fear learning

Researchers explore ins and outs of genome sequencing in newborns

Researcher awarded $1.8 million grant to explore how chronic stress impacts cancer development

Research finding provides new target for regulating cell division

New ‘5-D fingerprint’ technique could precisely measure properties of individual protein molecules

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

Study finds link between obesity-related disease and epigenetic modifications

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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