Efficacy News and Research

RSS

Researchers caution use of chloroquine therapy for patients at higher risk of heart rhythm abnormalities

A patient who met many of the published safety guidelines for chloroquine therapy against COVID-19 was observed to have a very abnormal ECG pattern after treatment began, leading to multiple episodes of torsade de pointes (TdP), a life-threatening arrhythmia in which the lower chambers of the heart beat out of sync with the upper chambers.

18 Jun 2020

AFFiRiS AG announces results of phase 1 trial with PD01A in Parkinson's

AFFiRiS AG, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies (SAITs), today announced that detailed results of the phase 1 clinical program with its lead candidate PD01 in early Parkinson's disease (PD) patients were published in the peer-reviewed journal The Lancet Neurology.

18 Jun 2020

Novel SARS-CoV-2 antibody cocktail impeccably mimics human antibody response

By using both humanized mice and convalescent patients, the researchers from the US and Singapore successfully generated non-competing and highly potent monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein that could potentially be combined to form antibody cocktails. Their groundbreaking paper is published in the leading research journal Science.

18 Jun 2020

Cyclosporin study may pave way for treating diseases related to mitochondrial dysfunction

Cyclic peptide molecules of the fungal origin called cyclosporins were discovered in 1970's, and cyclosporin A soon became an important drug due to its immunosuppressive activity.

18 Jun 2020

First genome-wide CRISPR screen reveals genes that control SARS-CoV-2 infection

By performing a genome-wide CRISPR screen on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), U.S. researchers identified novel proviral genes and pathways, and highlighted host genes that may regulate coronavirus disease (COVID-19) pathogenesis, as well as revealing potential targets for novel treatment approaches. Their findings are currently available on the bioRxiv* preprint server.

18 Jun 2020

Study: Vitamin D can reduce side effects associated with chemotherapy

As many cancer patients will confirm, the chemotherapy prescribed to kill the disease is often more debilitating than the cancer itself, with a range of horrendous side effects.

18 Jun 2020

Repurposing immunosuppressants to manage COVID-19

It might seem paradoxical to suggest immunosuppression could play a role in managing COVID-19. The seemingly logical therapeutic option for this disease would be an antiviral.

18 Jun 2020

Japanese health supplement could help tackle Covid-19 in people with comorbid conditions

A unique Beta 1,3-1,6 Glucan based Japanese health supplement, produced by black yeast, Aureobasidium Pullulans, could strategically help tackle Covid-19 in people with comorbid conditions like diabetes, kidney and heart diseases, as published in Frontiers in Immunology Journal recommending clinical studies, for validation.

18 Jun 2020

Impact Biomedical's COVID-19 research published in peer-reviewed scientific journal

SGX-listed Singapore eDevelopment Limited's wholly owned subsidiary Impact Biomedical Inc. announced today that their COVID-19 research with Global Research and Discovery Group Sciences, conducted in collaboration with Harvard Medical School and Vilotos Pharmaceutical, Inc., was published in the peer-reviewed scientific journal Molecules on June 11, 2020.

18 Jun 2020

C-Path's Transplant Therapeutics Consortium receives positive FDA response for its Letter of Intent

Critical Path Institute announced today that its Transplant Therapeutics Consortium has received a positive response to its Letter of Intent from the U.S. Food and Drug Administration detailing the decision to accept the Composite Biomarker Panel (iBox Scoring System) into the Center for Drug Evaluation and Research (CDER) Biomarker Qualification Program.

17 Jun 2020

Insufficient evidence for cognitive efficacy of drug treatments in multiple sclerosis

Researchers at Kessler Foundation conducted a comprehensive review of pharmacologic agents used in the treatment of multiple sclerosis, seeking evidence for efficacy for the cognitive dysfunction experienced by more than half of affected individuals.

17 Jun 2020

NAU research centers receive grants from Flinn Foundation to support COVID-19 response

Scientists at two Northern Arizona University research centers--the Pathogen and Microbiome Institute and the Center for Health Equity Research--recently received grants totaling $175,000 from the Flinn Foundation in support of projects directed at responding to the COVID-19 threat.

17 Jun 2020

Researchers call for caution of using CAR-T immunotherapy against AML

Acute myeloid leukemia is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous.

17 Jun 2020

Integrin-binding peptide ATN-161: Potential COVID-19 treatment

Now, a new study by researchers at Tulane University and published on the preprint server bioRxiv* in June 2020 reports the potential role of an integrin inhibitor ATN-161 to prevent ACE2-S protein binding.

17 Jun 2020

UConn researchers tackle a vexing problem in the development of vaccines

Researchers at UConn's Center of Excellence in Vaccine Research have made a breakthrough in vaccine development for a common and difficult to treat pneumonia-causing pathogen. Their research was recently published in the Nature Partner Journal - Vaccines.

17 Jun 2020

Benefits of convalescent plasma for COVID-19 patients still remain unclear

With vaccines and therapeutic drugs for COVID-19 still under development, doctors are wondering whether antibody-rich plasma infusions from the blood of recovered patients could be a more immediate way to keep hospitalized patients alive and off ventilators.

17 Jun 2020

New microscopy technique can be used to study the progression of wound healing

Researchers at the GSK Center for Optical Molecular Imaging have developed a new microscope that looks at the different parameters that change during wound healing. They hope to use this technique to understand how skin disorders, such as foot ulcers in diabetic patients and psoriasis, can be treated.

17 Jun 2020

Women with a history of miscarriage or subfertility more likely to have mild thyroid abnormalities

Mild thyroid abnormalities affect up to one in five women with a history of miscarriage or subfertility which is a prolonged time span of trying to become pregnant, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

17 Jun 2020

Discovery could significantly improve diagnosis of motor neuron disease

Scientists at the University of Sussex have identified a potential pattern within blood which signals the presence of motor neuron disease; a discovery which could significantly improve diagnosis.

17 Jun 2020

New nanoparticle drug combination can help treat atherosclerosis

Physicochemical cargo-switching nanoparticles (CSNP) designed by KAIST can help significantly reduce cholesterol and macrophage foam cells in arteries, which are the two main triggers for atherosclerotic plaque and inflammation.

17 Jun 2020

Efficacy News and Research

Researchers caution use of chloroquine therapy for patients at higher risk of heart rhythm abnormalities

AFFiRiS AG announces results of phase 1 trial with PD01A in Parkinson's

Novel SARS-CoV-2 antibody cocktail impeccably mimics human antibody response

Cyclosporin study may pave way for treating diseases related to mitochondrial dysfunction

First genome-wide CRISPR screen reveals genes that control SARS-CoV-2 infection

Study: Vitamin D can reduce side effects associated with chemotherapy

Repurposing immunosuppressants to manage COVID-19

Japanese health supplement could help tackle Covid-19 in people with comorbid conditions

Impact Biomedical's COVID-19 research published in peer-reviewed scientific journal

C-Path's Transplant Therapeutics Consortium receives positive FDA response for its Letter of Intent

Insufficient evidence for cognitive efficacy of drug treatments in multiple sclerosis

NAU research centers receive grants from Flinn Foundation to support COVID-19 response

Researchers call for caution of using CAR-T immunotherapy against AML

Integrin-binding peptide ATN-161: Potential COVID-19 treatment

UConn researchers tackle a vexing problem in the development of vaccines

Benefits of convalescent plasma for COVID-19 patients still remain unclear

New microscopy technique can be used to study the progression of wound healing

Women with a history of miscarriage or subfertility more likely to have mild thyroid abnormalities

Discovery could significantly improve diagnosis of motor neuron disease

New nanoparticle drug combination can help treat atherosclerosis

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News