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Researchers find low levels of neuroactive steroid in both obese and anorexic women

Women at opposite extremes of the weight spectrum have low levels of the neuroactive steroid allopregnanolone, according to new research published in the journal Neuropsychopharmacology.

10 Nov 2017

Common genetic fusion event could help identify patients with low-risk prostate cancer

Establishing the way in which a genetic alteration called a TMPRSS2-ERG gene fusion forms in a prostate cancer, rather than the presence of the gene fusion itself, could help identify patients with prostate cancer with a low risk of spreading, which might determine the best course of treatment for the patient.

10 Nov 2017

Malaria parasites’ decision making influenced by fatty molecule in human blood

Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team.

9 Nov 2017

Study finds potential chemical compound that initiated life on Earth

A new study conducted at The Scripps Research Institute (TSRI) has found a compound called diamidophosphate (DAP), which is expected to have played a vital role in the origins of life on Earth.

8 Nov 2017

ISPOR gains member feedback on new Women in HEOR initiative

ISPOR, the professional society for health economics and outcomes research, held an open meeting this afternoon that was designed to gain member feedback on a new initiative, "ISPOR Women in HEOR/Science."

8 Nov 2017

Adipocytes may reduce effectiveness of chemotherapeutic drug

Adipocytes, or fat cells, can absorb and metabolize the chemotherapeutic agent daunorubicin, reducing the effectiveness of the drug and potentially contributing to poorer treatment outcomes.

8 Nov 2017

Johns Hopkins scientists report first-ever creation of protein hydrogels inside living cells

Johns Hopkins cell biologists report what they believe is the first-ever creation of tiny protein-based gelatin-like clumps called hydrogels inside living cells.

7 Nov 2017

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.

1 Nov 2017

Study reveals unique molecules in the blood of people with MS

A breakthrough study led by the University of Sydney's Brain and Mind Centre and Royal Prince Alfred Hospital has revealed unique molecules in the blood of people with Multiple Sclerosis (MS) that could become definitive diagnostic biomarkers of the world's most common neurologic disability in young adults.

30 Oct 2017

ASCO's big-data, real-world health system revolutionizes future of cancer care

Future Science Group today announced the publication of an article in Future Oncology discussing the American Society of Clinical Oncology's CancerLinQ real-world, rapid learning health system.

28 Oct 2017

CHLA and Keck Medicine of USC develop new liquid biopsy for tumor of the retina

Retinoblastoma is a tumor of the retina that generally affects children under 5 years of age. If not diagnosed early, retinoblastoma may result in loss of one or both eyes and can be fatal. Unlike most cancers that are diagnosed using a biopsy, retinoblastoma tumors cannot be directly biopsied.

16 Oct 2017

TGen awarded $2.5 million SU2C grant to test new method of treating pancreatic cancer

Stand Up To Cancer has awarded a $2.5 million SU2C CatalystR grant to the Translational Genomics Research Institute to investigate a revolutionary new method of treating pancreatic cancer, one of the most aggressive of all cancers.

13 Oct 2017

AAPM&R endorses Perioperative Surgical Home model of care

The American Society of Anesthesiologists' Perioperative Surgical Home model of care's ability to significantly improve patient care, quality and reduce costs, has been endorsed by the American Academy of Physical Medicine and Rehabilitation, the premier professional association for physical medicine and rehabilitation physicians.

13 Oct 2017

Salk scientists receive $2.5 million funding to conduct pancreatic cancer clinical study

Salk Professor and HHMI Investigator Ronald Evans has been awarded $2.5 million by Stand Up 2 Cancer (SU2C) as part of a multi-institution team to conduct clinical studies to open up a new avenue for immunotherapy in the treatment of pancreatic cancer.

12 Oct 2017

Study provides detailed characterization of neurotoxicity arising from CD19 CAR T-cell therapy

New potential biomarkers and a novel algorithm could help identify patients at increased risk of suffering from severe neurotoxicity after receiving CD19 CAR T-cell therapy. The study extensively characterized common and occasionally fatal side effects of this immunotherapy.

12 Oct 2017

Eyes fixed on California as governor ponders inking drug price transparency bill

Insurers, hospitals, and health advocates are waiting for Gov. Jerry Brown to deal the drug lobby a rare defeat, by signing legislation that would force pharmaceutical companies to justify big price hikes on drugs in California.

6 Oct 2017

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today.

4 Oct 2017

Catalyst News and Research

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Common genetic fusion event could help identify patients with low-risk prostate cancer

Malaria parasites’ decision making influenced by fatty molecule in human blood

Study finds potential chemical compound that initiated life on Earth

ISPOR gains member feedback on new Women in HEOR initiative

Adipocytes may reduce effectiveness of chemotherapeutic drug

Johns Hopkins scientists report first-ever creation of protein hydrogels inside living cells

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

Study reveals unique molecules in the blood of people with MS

ASCO's big-data, real-world health system revolutionizes future of cancer care

CHLA and Keck Medicine of USC develop new liquid biopsy for tumor of the retina

TGen awarded $2.5 million SU2C grant to test new method of treating pancreatic cancer

AAPM&R endorses Perioperative Surgical Home model of care

Salk scientists receive $2.5 million funding to conduct pancreatic cancer clinical study

Study provides detailed characterization of neurotoxicity arising from CD19 CAR T-cell therapy

Eyes fixed on California as governor ponders inking drug price transparency bill

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

Alterations in circulating tumor DNA associated with response to checkpoint inhibitors

Chemotherapy may increase survival for advanced colon cancer patients with dementia, study suggests

Innovative new app could help enhance day-to-day lives of people with dementia

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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