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Investigating new cancer therapy candidates with live-cell imaging

There are two main things that we've worked on in the lab as regards to drug studies. One is identifying new combinations of drugs, and working on why a combination of drugs should work better than each alone.

From Sartorius 16 Oct 2017

McGill researchers discover new cellular mechanism in Alzheimer's disease

McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer's disease.

13 Oct 2017

CGT Catapult’s iPSC line licensed to Universal Cells for creating universal donor cell line

The Cell and Gene Therapy Catapult today announced a non-exclusive licensing agreement to provide its clinical-grade induced Pluripotent Stem Cell line to Seattle based Universal Cells.

6 Oct 2017

Plant extracts may help protect against negative effects of X-ray irradiation

A compound found in coriander and ginger may help protect against the negative effects of radiation exposure.

3 Oct 2017

Penn study provides insight into how cells maintain identity during replication

Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates sort themselves out by condensing, becoming thousands of times more compact than at any other time.

15 Sep 2017

Boise State professor wins federal grant to explore basic functions of the genome

It's rare for a faculty member in any physics department to earn a federal grant administered by the National Institutes of Health, but that is exactly what Boise State assistant professor and biophysicist Matt Ferguson has done.

14 Sep 2017

Researchers reveal possible origin of cancer-associated fibroblasts

Researchers at Okayama University describe in Scientific Reports that cancer-associated fibroblasts — cells that play a key role in cancer progression — originate from cancer stem cells. Preventing cancer stem cells from transforming into cancer-associated fibroblast may be a promising approach towards cancer treatment.

12 Sep 2017

New microfluidic device offers insights on cancer metastasis

As cancer grows, it evolves. Individual cells become more aggressive and break away to flow through the body and spread to distant areas.

7 Sep 2017

Increased enzyme production by the liver causes fatty liver, obesity and insulin resistance

In mice that are given a high-fat diet, an increased production of the enzyme DPP4 by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance.

24 Aug 2017

New strategy allows researchers to identify potential treatments for altered levels of MeCP2

Having twice the normal amount of the protein MeCP2, a condition called MECP2 duplication syndrome, causes severe progressive neuropsychiatric disorders that include intellectual disability, autism spectrum disorders, motor dysfunction and other medical complications.

24 Aug 2017

Researchers develop and validate new assay that detects gene fusions in solid tumors

An assay that identifies a peculiar but important abnormality in cancer cells has been developed and validated by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

14 Aug 2017

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer Center report in the journal Leukemia.

13 Jul 2017

Newly identified biomarker panel could pave way to earlier detection of pancreatic cancer

A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research from the Perelman School of Medicine at University of Pennsylvania.

12 Jul 2017

Computational analysis of open-access data points to new ways of using drugs

A research team led by scientists at UC San Francisco has developed a computational method to systematically probe massive amounts of open-access data to discover new ways to use drugs, including some that have already been approved for other uses.

12 Jul 2017

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June 19 in the journal Nature Neuroscience.

27 Jun 2017

Researchers discover broad role for DNA-cutting enzyme in driving abnormal genetic rearrangements

Researchers studying a DNA-cutting enzyme with a crucial role in regulating the structure of genes have discovered a broad role for its cutting activity in driving abnormal genetic rearrangements called translocations that cause cancer, including leukemias and solid tumors.

16 Jun 2017

Cell Line News and Research

Investigating new cancer therapy candidates with live-cell imaging

McGill researchers discover new cellular mechanism in Alzheimer's disease

CGT Catapult’s iPSC line licensed to Universal Cells for creating universal donor cell line

Plant extracts may help protect against negative effects of X-ray irradiation

Penn study provides insight into how cells maintain identity during replication

Boise State professor wins federal grant to explore basic functions of the genome

Researchers reveal possible origin of cancer-associated fibroblasts

New microfluidic device offers insights on cancer metastasis

Increased enzyme production by the liver causes fatty liver, obesity and insulin resistance

New strategy allows researchers to identify potential treatments for altered levels of MeCP2

Researchers develop and validate new assay that detects gene fusions in solid tumors

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

Newly identified biomarker panel could pave way to earlier detection of pancreatic cancer

Computational analysis of open-access data points to new ways of using drugs

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Researchers discover broad role for DNA-cutting enzyme in driving abnormal genetic rearrangements

Mutations identified that enable human transmission of avian flu

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Rice University scientists develop and evaluate analogs of potent cancer fighters

Study points to new pharmacologic approach to target chemo-resistant lung cancer

Automated colony picking: Comparing technologies for efficient clone screening eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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