DNA Sequencing News and Research

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Scientists use novel metagenomic approaches to characterize microbial communities that reside in human gut

The gut microbiota contains a vast number of microorganisms from all three domains of life, including bacteria, archaea and fungi, as well as viruses. These interact in a complex way to contribute towards both health and the development of disease - interactions that are only now being elucidated thanks to the application of advanced DNA sequencing technology in this field.

10 Mar 2014

Safeguard Scientifics reports net income of $24 million for fourth quarter 2013

Safeguard Scientifics, Inc. today announced fourth quarter and full-year 2013 financial results. For the three months ended December 31, 2013, Safeguard's net income was $24.0 million, or $1.10 per share, compared to net loss of $10.8 million, or $0.51 per share for the same period in 2012. For the year ended December 31, 2013, Safeguard's net loss was $35.5 million, or $1.66 per share, compared to $39.4 million, or $1.88 per share for the same period in 2012.

6 Mar 2014

Study to understand role of bacterium in heart valve disease

A disease-causing bacterium found in the mouth needs manganese, a trace mineral, in order to cause a serious heart infection, according to a preclinical study led by researchers at Virginia Commonwealth University Philips Institute for Oral Health Research in the School of Dentistry.

6 Mar 2014

Set of genes appear to predict which tumors can evade detection by immune system

Johns Hopkins researchers say they have identified a set of genes that appear to predict which tumors can evade detection by the body's immune system, a step that may enable them to eventually target only the patients most likely to respond best to a new class of treatment.

5 Mar 2014

Medical diagnoses, DNA sequencing can be made faster through gel electrophoresis

Medical diagnoses and DNA sequencing can be made cheaper, faster and more reliable using a new miniaturized technique for gel electrophoresis based on conducting polymer materials, according to researchers at Link-ping University in Sweden.

5 Mar 2014

Researchers identify genes that appear to predict tumors that can evade detection by immune system

Johns Hopkins researchers say they have identified a set of genes that appear to predict which tumors can evade detection by the body’s immune system, a step that may enable them to eventually target only the patients most likely to respond best to a new class of treatment.

5 Mar 2014

Novel scaffold protein regulates mu opioid receptor induced signaling activation

Researchers found initial confirmation that a novel scaffold protein previously unassociated with the mu opioid receptor (MOR) regulates MOR-induced signaling activation.

4 Mar 2014

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

A study in this week's New England Journal of Medicine potentially has significant implications for prenatal testing for major fetal chromosome abnormalities. The study found that in a head-to-head comparison of noninvasive prenatal testing using cell free DNA (cfDNA) to standard screening methods, cfDNA testing (verifi- prenatal test, Illumina, Inc.) significantly reduced the rate of false positive results and had significantly higher positive predictive values for the detection of fetal trisomies 21 and 18.

From Illumina, Inc. 27 Feb 2014

Study identifies enzyme with key role in precancerous lesions

Cancer of the pancreas is usually not detected until it's too late to cure. But precursor lesions that form in the pancreas and its ducts can signal the disease before it strikes, and when caught early enough, they can be prevented from progressing to become cancer.

26 Feb 2014

Researchers discover 'microbial Pompeii' preserved on teeth of skeletons around 1,000 years old

An international team of researchers have discovered a 'microbial Pompeii' preserved on the teeth of skeletons around 1,000 years old. The key to the discovery is the dental calculus (plaque) which preserves bacteria and microscopic particles of food on the surfaces of teeth, effectively creating a mineral tomb for microbiomes.

24 Feb 2014

Researchers discover 11 DNA sequence variants in genes influencing high BP, heart disease

New research from Queen Mary University of London has discovered 11 new DNA sequence variants in genes influencing high blood pressure and heart disease.

24 Feb 2014

MATH biomarker with HPV status may provide improved outcomes in HNSCC patients

Evaluating next-generation sequencing (NGS) data and associated clinical records of head and neck squamous cell carcinoma (HNSCC) patients from several institutions, made available through The Cancer Genome Atlas (TCGA), showed that combining Mutant-Allele Tumor Heterogeneity (MATH) as a biomarker with the patient's HPV status provides an effective indicator of improved patient outcome, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

21 Feb 2014

Scientists produce reliable set of genotypes to benchmark human genome sequencing

Led by biomedical engineer Justin Zook of the National Institute of Standards and Technology, a team of scientists from Harvard University and the Virginia Bioinformatics Institute of Virginia Tech has presented new methods to integrate data from different sequencing platforms, thus producing a reliable set of genotypes to benchmark human genome sequencing.

19 Feb 2014

Discovery could lead to improved early detection, prevention strategies for sudden cardiac death

UC Irvine researchers have found a specific genetic flaw that is connected to sudden death due to heart arrhythmia - a leading cause of mortality for adults around the world.

18 Feb 2014

The Future of DNA Sequencing

In this interview, Barret Bready discusses the current gold standards in DNA sequencing and how the Nabsys platform is revolutionizing this process.

18 Feb 2014

Small non-coding RNAs can help predict individuals with breast cancer

Small non-coding RNAs can be used to predict if individuals have breast cancer conclude researchers who contribute to The Cancer Genome Atlas project. The results, which are published in EMBO reports, indicate that differences in the levels of specific types of non-coding RNAs can be used to distinguish between cancerous and non-cancerous tissues. These RNAs can also be used to classify cancer patients into subgroups of individuals that have different survival outcomes.

18 Feb 2014

Studies shed more light on genetic basis of bone marrow failure

The study, published in The American Journal of Human Genetics, detected and identified a new disease gene (ERCC6L2). In its normal form, the gene plays a key role in protecting DNA from damaging agents, but when the gene is mutated the cell is not able to protect itself in the normal way.

7 Feb 2014

Study: Sensitivity to pain could be altered by person's lifestyle and environment

Researchers at King's College London have discovered that sensitivity to pain could be altered by a person's lifestyle and environment throughout their lifetime. The study is the first to find that pain sensitivity, previously thought to be relatively inflexible, can change as a result of genes being switched on or off by lifestyle and environmental factors - a process called epigenetics, which chemically alters the expression of genes.

5 Feb 2014

Treating peanut allergy with oral immunotherapy changes DNA of immune cells

Treating a peanut allergy with oral immunotherapy changes the DNA of the patient's immune cells, according to a new study from the Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford. The DNA change could serve as the basis for a simple blood test to monitor the long-term effectiveness of the allergy therapy.

31 Jan 2014

Researchers study how epigenetic alterations contribute to age-related increases in breast cancer risk

Age is a key risk factor for breast cancer. A recent study by researchers from the Dartmouth-Hitchcock Norris Cotton Cancer Center, "Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation," examines the connection between cancer and the aging process to see if epigenetic DNA alterations might contribute to age-related increases in breast cancer risk.

31 Jan 2014

DNA Sequencing News and Research

Scientists use novel metagenomic approaches to characterize microbial communities that reside in human gut

Safeguard Scientifics reports net income of $24 million for fourth quarter 2013

Study to understand role of bacterium in heart valve disease

Set of genes appear to predict which tumors can evade detection by immune system

Medical diagnoses, DNA sequencing can be made faster through gel electrophoresis

Researchers identify genes that appear to predict tumors that can evade detection by immune system

Novel scaffold protein regulates mu opioid receptor induced signaling activation

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

Study identifies enzyme with key role in precancerous lesions

Researchers discover 'microbial Pompeii' preserved on teeth of skeletons around 1,000 years old

Researchers discover 11 DNA sequence variants in genes influencing high BP, heart disease

MATH biomarker with HPV status may provide improved outcomes in HNSCC patients

Scientists produce reliable set of genotypes to benchmark human genome sequencing

Discovery could lead to improved early detection, prevention strategies for sudden cardiac death

The Future of DNA Sequencing

Small non-coding RNAs can help predict individuals with breast cancer

Studies shed more light on genetic basis of bone marrow failure

Study: Sensitivity to pain could be altered by person's lifestyle and environment

Treating peanut allergy with oral immunotherapy changes DNA of immune cells

Researchers study how epigenetic alterations contribute to age-related increases in breast cancer risk

How to optimize sample preparation for NGS? eBook

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