Pathogen News and Research

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Antibiotic-resistant bacteria in Ghana confined to clinical settings

Calland, J. K., et al. (2023). Population structure and antimicrobial resistance among Klebsiella isolates sampled from human, animal, and environmental sources in Ghana: a cross-sectional genomic One Health study. The Lancet Microbe. doi.org/10.1016/S2666-5247(23)00208-2.

16 Oct 2023

Study reveals previously unappreciated role for innate immune cells in early stages of TB infection

A new study from the University of Pittsburgh Center for Vaccine Research published today in the Journal of Experimental Medicine describes a previously unappreciated role for a class of immune cells in the early stages of tuberculosis (TB) infection.

16 Oct 2023

Study shows widespread prevalence of dangerous pathogens in ventilated patients

University of Maryland School of Medicine (UMSOM) researchers conducted a statewide survey of all patients on breathing machines in hospitals and long-term care facilities and found that a significant percentage of them harbored two pathogens known to be life-threatening in those with compromised immune systems.

15 Oct 2023

Study identifies significant percentage of ventilated patients colonized with life-threatening pathogens

13 Oct 2023

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

Gut microbiota and macrophage-neutrophil interactions in the impact of dietary phenolic acids on intestinal inflammation.

11 Oct 2023

Nasal mupirocin found to be highly effective at preventing Staphylococcus aureus infections in critically ill patients

A large multi-state study by the Centers for Disease Control and Prevention, the Harvard Pilgrim Health Care Institute, HCA Healthcare, and the University of California, Irvine has found that a nasal antibiotic ointment, mupirocin, which is currently used daily for intensive care unit (ICU) patients in only one-third of U.S. hospitals, is highly effective at preventing Staphylococcus aureus infections in critically ill patients, outperforming an antiseptic solution.

10 Oct 2023

RSV in seniors: Less common than COVID-19, but hits harder, CDC study reveals

In a recent CDC's MMWR study, researchers found that while respiratory syncytial virus (RSV) infections are less common than COVID-19 and influenza in Americans aged 60+ years, they result in much more severe clinical outcomes. This insight supports the CDC's recommendation for RSV vaccination in older adults, emphasizing its potential in preventing severe respiratory disease.

10 Oct 2023

Halting pandemics at the source: The call for a proactive 'One Health' approach

The recent PLoS Pathogens review emphasizes proactively preventing pathogen spillover from animals to humans as a strategy against future pandemics, advocating for a holistic One Health approach that considers the interconnectedness of humans, animals, and the environment. The study underscores the importance of primary prevention, differentiating it from secondary containment, and highlights the economic and societal benefits of preemptive actions over reactive responses.

10 Oct 2023

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

In the latest research published in Science Immunology, experts delve into the gene expression patterns of distinct intraepithelial lymphocyte populations in various gastrointestinal tract regions. Key findings reveal the roles of T-cell IELs in detecting infections and ensuring the gut's barrier integrity, with a special emphasis on their function in combating colon cancer.

9 Oct 2023

Immature immune cells near dural sinuses linked to neonatal viral meningoencephalitis

Examine virus propagation within central nervous systems (CNSs) during systemic infection.

9 Oct 2023

Differences in immune responses to SARS-CoV-2 variants could inform future vaccine design

A person's immune response to variants of SARS-CoV-2, the virus that causes COVID-19, depends on their previous exposure - and differences in the focus of immune responses will help scientists understand how to optimize vaccines in the future to provide broad protection.

6 Oct 2023

USC-led team develops vaccine to boost immune system against superbugs

What if a vaccine, given to patients just before or after arriving at the hospital, could protect them against lethal superbugs that lurk in healthcare settings?

5 Oct 2023

Using portable laboratory devices for rapid and sensitive on-site detection of SARS-CoV-2

A new study has demonstrated rapid and sensitive on-site detection of SARS-CoV-2 RNA from environmental surfaces using a portable laboratory device.

5 Oct 2023

'Guard mechanism' discovered for protein that attacks microbes in infected cells

Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.

5 Oct 2023

New insights into how neutrophils fight Candida albicans infection

Umeå University researchers, Sweden, unveil how the most common white blood cells, neutrophils, counter Candida albicans toxin stopping its tracks.

5 Oct 2023

Organoid medicine reveals promising covid-19 treatment target

When the new SARS-CoV-2 virus began killing thousands of people every week, physicians and scientists around the globe raced to learn why the new pathogen was so deadly.

5 Oct 2023

Can falsified or substandard antimicrobials increase antimicrobial resistance?

The association between substandard or falsified (SF) antibiotics and antimicrobial resistance (AMR).

5 Oct 2023

New nasal vaccine shows promise in preventing deadly Strep A infections

As Streptococcus A cases continue to be prevalent in Queensland and internationally, a new nasal vaccine could provide long-term protection from the deadly bacteria.

4 Oct 2023

Could infants' robust immune responses reshape future vaccination strategies?

Utilizing next-gen sequencing techniques, researchers analyzed infants' immune responses to infections, uncovering a predominant innate immune activation unlike adults and older children. This insight could steer child vaccination research and pediatric infection management strategies, potentially revolutionizing infant healthcare.

3 Oct 2023

Brigham researchers quantify the burden of SARS-CoV-2-associated sepsis

Using data from Mass General Brigham's electronic health records, Brigham researchers quantified the burden of SARS-CoV-2-associated sepsis early in the pandemic.

29 Sep 2023

Pathogen News and Research

Antibiotic-resistant bacteria in Ghana confined to clinical settings

Study reveals previously unappreciated role for innate immune cells in early stages of TB infection

Study shows widespread prevalence of dangerous pathogens in ventilated patients

Study identifies significant percentage of ventilated patients colonized with life-threatening pathogens

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

Nasal mupirocin found to be highly effective at preventing Staphylococcus aureus infections in critically ill patients

RSV in seniors: Less common than COVID-19, but hits harder, CDC study reveals

Halting pandemics at the source: The call for a proactive 'One Health' approach

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

Immature immune cells near dural sinuses linked to neonatal viral meningoencephalitis

Differences in immune responses to SARS-CoV-2 variants could inform future vaccine design

USC-led team develops vaccine to boost immune system against superbugs

Using portable laboratory devices for rapid and sensitive on-site detection of SARS-CoV-2

'Guard mechanism' discovered for protein that attacks microbes in infected cells

New insights into how neutrophils fight Candida albicans infection

Organoid medicine reveals promising covid-19 treatment target

Can falsified or substandard antimicrobials increase antimicrobial resistance?

New nasal vaccine shows promise in preventing deadly Strep A infections

Could infants' robust immune responses reshape future vaccination strategies?

Brigham researchers quantify the burden of SARS-CoV-2-associated sepsis

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