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Proximity labeling to identify high-confidence SARS-CoV-2 interactors

A recent report published in the STAR Protocols journal depicted a protocol for an antibody-based proximity labeling to discover biotinylated interactors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 May 2022

Study explores SARS-CoV-2 RNA genome's functional interactions with host cell

In a new study, a worldwide map of the SARS-CoV-2 genome-associated host proteins was developed by a team of researchers using the identification of RNA-binding protein by MS (ChIRP-MS) technique.

3 May 2022

The potency of halicin against the main protease of SARS-CoV-2

A new paper published in Current Research in Chemical Biology discusses the potential of a molecule called halicin against SARS-CoV-2.

26 Apr 2022

Most blood tests to detect Alzheimer’s disease perform inconsistently across racial groups

Three experimental blood tests used to identify people in early stages of Alzheimer's disease perform differently in Black individuals compared to white individuals, according to a new study from Washington University School of Medicine in St. Louis.

21 Apr 2022

Acquiring real-time, accurate and reproducible 4D bioinformatics data with PaSER

In this interview, Chris Adams Ph.D., Business Development Director, Global Bioinformatics, Life Science Mass Spectrometry at Bruker Daltonics, Billerica, MA, USA talks to News-Medical Life Sciences about acquiring real-time, accurate and reproducible 4D-proteomics data with PaSER.

From Bruker Daltonics 20 Apr 2022

The brain's reaction to COVID's inflammatory tidal wave

Researchers study neuroinflammation in the cerebrospinal fluid and serum of patients infected with SARS-CoV-2.

18 Apr 2022

Study investigates the production of a virosome-based COVID-19 vaccine candidate

In a new study, different signal peptides, baculovirus transfer vectors, cell lines, infection techniques, and formulation buffers were investigated with the purpose of building a scalable bioprocess to generate high-quality S protein for incorporation in a virosome-based COVID-19 vaccine candidate.

18 Apr 2022

Cell’s production of lipids can be a key factor in determining cell fate

How does a cell "decide" what type of cell to become? The question of "cell fate" has been explored for decades now, especially in the context of stem cell biology, but there are still gaps in our understanding.

15 Apr 2022

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.

13 Apr 2022

Researchers make progress to develop a drug for treating metabolic syndrome

Metabolic syndrome increases a person's risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar.

11 Apr 2022

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Researchers performed high-throughput evolutionary analyses of genes encoding 334 SARS-CoV-2 viral-interacting proteins of modern humans, primates, and bats.

11 Apr 2022

Ultralong bovine antibody targets cryptic and conserved epitope on SARS-CoV and SARS-CoV-2

Researchers identified an ultralong bovine antibody that neutralizes SARS-CoV-2 and SARS-CoV.

11 Apr 2022

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

COVID-19 could change the levels of proteins related to male reproductive function

Many people who recover from COVID-19 experience long-term symptoms, such as brain fog or heart problems. Increasing evidence suggests that the virus can also impair fertility.

7 Apr 2022

Molecular signature of highly stereotyped clonotypic anti-PF4 antibodies indicates shared pathways of antibody production in VITT patients

A recent study analyzed the antibody that mediated the COVID-19 vaccine-induced thrombotic thrombocytopenia.

7 Apr 2022

UCI researchers reveal the impact of native lipids on rhodopsin signaling and regeneration

In a new study at University of California, Irvine, researchers have revealed the impact of native lipids on rhodopsin signaling and regeneration, which may usher in a new paradigm for discovery of drugs that target G protein-coupled receptors (GPCRs).

6 Apr 2022

Spectrometry News and Research

Proximity labeling to identify high-confidence SARS-CoV-2 interactors

Study explores SARS-CoV-2 RNA genome's functional interactions with host cell

The potency of halicin against the main protease of SARS-CoV-2

Most blood tests to detect Alzheimer’s disease perform inconsistently across racial groups

Acquiring real-time, accurate and reproducible 4D bioinformatics data with PaSER

The brain's reaction to COVID's inflammatory tidal wave

Study investigates the production of a virosome-based COVID-19 vaccine candidate

Cell’s production of lipids can be a key factor in determining cell fate

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

Researchers make progress to develop a drug for treating metabolic syndrome

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Ultralong bovine antibody targets cryptic and conserved epitope on SARS-CoV and SARS-CoV-2

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

COVID-19 could change the levels of proteins related to male reproductive function

Molecular signature of highly stereotyped clonotypic anti-PF4 antibodies indicates shared pathways of antibody production in VITT patients

UCI researchers reveal the impact of native lipids on rhodopsin signaling and regeneration

Researchers develop novel device to “cleanse” the blood of chemotherapeutic drugs

Study highlights immune escape mutations in viral N-terminal domain supersite of SARS-CoV-2 spike variants

Gut bacterium may be an important factor in resistance to antihypertensive medications

Researchers use breast milk to identify new set of protein biomarkers for cancer

Enhancing confidence in chemical ionization spectrometry data eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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