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Study suggests interactions between distant DNA regions may impact disease gene levels

A person's DNA sequence can provide a lot of information about how genes are turned on and off, but new research out of Case Western Reserve University School of Medicine suggests the 3-D structure DNA forms as it crams into cells may provide an additional layer of gene control.

21 Sep 2016

Researchers use novel technique to unravel key mystery of earliest stage of development

A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or "epigenetic") modifications made to the protein packaging of DNA using a small population of cells.

20 Sep 2016

De-bookmarking could be key to better reprogramming of fibroblasts into iPS cells

In reading, a bookmark tells where you stopped. Cells use bookmarks too, specific proteins that help the cell remember what collection of genes needs to be turned on again after the brief halt of gene expression during cell division.

20 Sep 2016

Tendency to feel lonely linked partially to genetic traits

Loneliness is linked to poor physical and mental health, and is an even more accurate predictor of early death than obesity.

20 Sep 2016

Gene therapy may be viable approach for treating CF lung problems

Two new studies from the University of Iowa suggest that gene therapy may be a viable approach for treating or preventing lung disease caused by cystic fibrosis.

20 Sep 2016

CBN neuroscientists awarded NIMH grant to develop novel genome engineering research tools

The Center for Behavioral Neuroscience at Georgia State University has received a two-year, exploratory grant from the National Institute of Mental Health to develop transformative genome engineering research tools.

20 Sep 2016

Researchers underscore importance of immune-based prevention to conquer cancer

In a Perspective piece published this week in PNAS, cancer researchers from across the country, including faculty at University of California San Diego School of Medicine and Moores Cancer Center, write that a greater emphasis on immune-based prevention should be central to new efforts like the federal Cancer Moonshot program, headed by Vice President Joe Biden.

19 Sep 2016

Researchers identify mutant traits in mouse for many human disease genes

About one-third of all genes in the mammalian genome are essential for life. An international, multi-institutional research collaboration identified, for the first time, mutant traits in the mouse for 52 human disease genes, which significantly contributes to the understanding of the genetic bases for some human diseases, including cardiovascular defects, spina bifida, and metabolic disorders, among many others. The study was published this week in Nature.

19 Sep 2016

Researchers find switch that helps restore damaged axons

Researchers at the University of Wisconsin-Madison have found a switch that redirects helper cells in the peripheral nervous system into "repair" mode, a form that restores damaged axons.

16 Sep 2016

Chromatrap reports benefits of using ChIP-seq kit for histone methylation applications

Chromatrap reports on the advantages of using its Chromatin Immunoprecipitation Sequencing (ChIP-seq) assay kits for histone methylation applications.

From Chromatrap® - Porvair Sciences Ltd 16 Sep 2016

ATR inhibitors show improved survival and effectiveness in animal models of cancer

Tumours are an accumulation of cells that divide without control, accumulating hundreds of chromosomal alterations and mutations in their DNA.

13 Sep 2016

Novel DNA-altering method could lead to more treatment options for diseases

Researchers in Singapore have developed a new protein that can alter DNA in living cells with much higher precision than current methods.

13 Sep 2016

NUS study reveals RNA editing events play vital role in gastric cancer development

A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore has found that changes in ribonucleic acid (RNA) sequences play a major role in the development of gastric cancer.

13 Sep 2016

New four-stranded version of DNA may hold key to development of targeted cancer therapies

Scientists have identified where a four-stranded version of DNA exists within the genome of human cells, and suggest that it may hold a key to developing new, targeted therapies for cancer.

13 Sep 2016

Researchers uncover specific sites in the genome linked to high blood pressure

Three large, collaborating international consortia of researchers, including a team co-led by investigators from Brigham and Women's Hospital, have uncovered new genes and sites in the genome tied to elevated blood pressure, implicating certain biological pathways and pointing toward new therapeutic strategies for treating hypertension.

12 Sep 2016

Research reveals how Zika virus arrests fetal brain development in pigtail macaque

For the first time, abnormal brain development following a Zika infection during pregnancy has been documented experimentally in the offspring of a non-human primate.

12 Sep 2016

Genome-wide studies reveal evolutionary conserved enzyme facilitates DNA replication

Genome-wide studies of fission yeast (Schizosaccharomyces pombe) suggest that the evolutionary conserved enzyme Pfh1 helicase facilitates DNA synthesis by tracking along with the replication apparatus, promoting intact DNA synthesis at hard-to-replicate sites and consequently suppressing DNA damage. The findings are published in PLOS Genetics.

12 Sep 2016

Researchers identify how ionising radiation can cause cancer by damaging DNA

For the first time, researchers from the Wellcome Trust Sanger Institute and their collaborators have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionising radiation.

12 Sep 2016

Novel controlled clinical trial finds Ayurvedic-based well-being program can alter blood-based metabolites

In a novel controlled clinical trial, participants in a six-day Ayurvedic-based well-being program that featured a vegetarian diet, meditation, yoga and massages experienced measurable decreases in a set of blood-based metabolites associated with inflammation, cardiovascular disease risk and cholesterol regulation.

9 Sep 2016

UAB researchers find microRNA as potential therapeutic target for MDD

A tiny RNA appears to play a role in producing major depression, the mental disorder that affects as many as 250 million people a year worldwide.

9 Sep 2016

Genome News and Research

Study suggests interactions between distant DNA regions may impact disease gene levels

Researchers use novel technique to unravel key mystery of earliest stage of development

De-bookmarking could be key to better reprogramming of fibroblasts into iPS cells

Tendency to feel lonely linked partially to genetic traits

Gene therapy may be viable approach for treating CF lung problems

CBN neuroscientists awarded NIMH grant to develop novel genome engineering research tools

Researchers underscore importance of immune-based prevention to conquer cancer

Researchers identify mutant traits in mouse for many human disease genes

Researchers find switch that helps restore damaged axons

Chromatrap reports benefits of using ChIP-seq kit for histone methylation applications

ATR inhibitors show improved survival and effectiveness in animal models of cancer

Novel DNA-altering method could lead to more treatment options for diseases

NUS study reveals RNA editing events play vital role in gastric cancer development

New four-stranded version of DNA may hold key to development of targeted cancer therapies

Researchers uncover specific sites in the genome linked to high blood pressure

Research reveals how Zika virus arrests fetal brain development in pigtail macaque

Genome-wide studies reveal evolutionary conserved enzyme facilitates DNA replication

Researchers identify how ionising radiation can cause cancer by damaging DNA

Novel controlled clinical trial finds Ayurvedic-based well-being program can alter blood-based metabolites

UAB researchers find microRNA as potential therapeutic target for MDD

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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