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Study suggests new approach to ameliorating obesity-associated metabolic abnormalities

The search by scientists to find ways to combat obesity continues. Recently, investigators have been exploring whether they can engage the lymphatic system to help regulate obesity-induced inflammation of fat (adipose) tissue and restore systemic metabolic fitness.

14 Mar 2019

Blunting emotional component associated with pain

Chronic pain involves more than just hurting. People suffering from pain often experience sadness, depression and lethargy. That's one reason opioids can be so addictive -- they not only dampen the pain but also make people feel euphoric.

13 Mar 2019

Blood donors' leftover immune cells provide crucial insights into antibody affinity

During some kinds of blood donations, you get most of your blood back. For example, platelet donation involves a procedure in which donor blood is filtered to harvest the platelets for medical use and the rest of the blood components are returned to the donor's body.

11 Mar 2019

Researchers find potential new target for chronic pain treatment

A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain.

7 Mar 2019

Inflammation in the brain increases side-effects of hypnotic drugs

In a study recently published in the European Journal of Pharmacology researchers at Okayama University show how the presence of inflammation in the brain can increase its sensitivity to benzodiazepines.

7 Mar 2019

Mechanism through which bacteria attack the immune system discovered

A research team led by Prof. Dr. Winfried Römer and Dr. Elias Hobeika from the University of Freiburg and the University Medical Center in Ulm has discovered a mechanism with which bacteria activate white blood cells and attack an organism's immune system. The scientists recently published the results in the journal Science Signaling.

7 Mar 2019

CAR-T cell therapy could be on the horizon for patients with lupus

Researchers have developed a novel CAR-T cell therapy that can reduce B cell numbers known to cause the inflammatory responses in lupus.

7 Mar 2019

Anti-inflammatory drug shown to promote cardiac reprogramming

Once damaged, the human heart does a poor job of repairing itself, so this is a key priority for treating heart failure. One way of restoring cardiac function is to reprogram non-cardiac body cells such as fibroblasts into heart muscle cells (cardiomyocytes) using a collection of cardiac transcription factors.

6 Mar 2019

Genetic manipulation can double life expectancy and increase health of offspring

By manipulating the genes that make humans age, researchers have discovered that lifespans can be doubled with a better quality of life for offspring.

6 Mar 2019

Many heroin users are not prepared to prevent or treat fentanyl-related overdoses, study finds

Most heroin users in Baltimore, a city heavily affected by the opioid epidemic, recognize that the heroin they buy is now almost always laced with the highly dangerous synthetic opioid fentanyl, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

6 Mar 2019

Researchers discover facile method for introduction of fluorine atoms into organic molecules

The vast majority of pharmaceuticals employed in the treatment of human diseases are of an organic nature, meaning that the active component is a molecule (or a combination of several molecules) that is constituted of carbon and hydrogen atoms.

6 Mar 2019

Liver tissue model can help investigate the effects of RNA interference

Novel therapies based on a process known as RNA interference hold great promise for treating a variety of diseases by blocking specific genes in a patient's cells. Many of the earliest RNAi treatments have focused on diseases of the liver, because RNA-carrying particles tend to accumulate in that organ.

6 Mar 2019

New insights into influenza A infection and its spread

A new route of influenza A infection viruses has been discovered by the researchers at the Medical Center - University of Freiburg and the University of Zurich. At present the knowledge regarding influenza A infection spread is mainly restricted to the binding of the sialic moieties of the virus to the cell surface of the host.

5 Mar 2019