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CENTOGENE teams up with Insilico Medicine to improve therapeutic targets for Niemann-Pick disease type C

A commercial-stage company focused on generating data-driven insights to diagnose, understand and treat rare diseases, and Insilico Medicine, an end-to-end Artificial Intelligence (AI) - driven drug discovery company, today announced a research and development collaboration to accelerate the discovery of novel therapeutic targets for Niemann-Pick disease type C

21 Jan 2022

Oral supplement appears to promote muscle endurance and mitochondrial health in humans

An oral supplement intended to stimulate a natural body process appears to promote muscle endurance and mitochondrial health in humans.

20 Jan 2022

Cancer patients receiving treatment may mount inadequate immune response to COVID-19 vaccination

A study by researchers at Mayo Clinic Cancer Center has found that patients with cancer who receive chemotherapy - and some targeted therapies, such as CDK4/6 inhibitors and therapies targeted at B cells - may mount an inadequate immune response to COVID-19 vaccination.

20 Jan 2022

Mice study identifies ventral spinocerebellar tract neurons that control locomotion

For more than a century, scientists have known that while the commands that initiate movement come from the brain, the neurons that control locomotion once movement is underway reside within the spinal cord.

20 Jan 2022

Study: Many incarcerated pregnant people with opioid use disorder do not receive standard of care treatment

In a large survey study looking at the availability of medications for opioid use disorder (MOUD) for pregnant and postpartum people in United States jails, Johns Hopkins Medicine researchers found that a substantial number of facilities fail to consistently provide standard MOUD to this group.

20 Jan 2022

Could heart rate be a risk factor for dementia?

In this interview, we speak to Dr. Yume Imahori about her latest research which looks at whether heart rate could be used as an early risk factor for dementia.

20 Jan 2022

Researchers explore furin inhibitors as a potential tool for treating COVID-19 infection

A new study suggests that coronaviruses such as SARS-CoV-2 depend on a furin cleavage site between the S1/S2 subunits to enhance viral infectivity.

20 Jan 2022

Cannabis companies flout state regulations to market products in a way that appeals to children

Many recreational cannabis companies market their products in a way that appeals to children and teens, despite state-based regulations prohibiting it, according to a new study in the Journal of Studies on Alcohol and Drugs.

20 Jan 2022

Variants of SARS-CoV-2 and preventive strategies

A recent review article published in the journal Advanced Science reviewed the features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants. Using a physical and materials science perspective, the review also summarizes the most significant variants of SARS-CoV-2 encountered to date as well as possible preventive strategies.

19 Jan 2022

New mathematical model can calculate the risk of resistance evolution for drug pairs

Bacteria have dangerously evolved to thwart many of the medicines that were designed to kill them. As a result, a growing antibiotic resistance crisis is responsible for more than 700,000 deaths each year, emerging as one of the world's most pressing health issues.

19 Jan 2022

Study identifies a new potential pathway for developing therapeutics against Epstein-Barr virus

A new study by researchers at The Wistar Institute, an international biomedical research leader in cancer, immunology, infectious disease, and vaccine development, has identified a new potential pathway for developing therapeutics that target Epstein-Barr virus (EBV).

19 Jan 2022

A comprehensive analysis places antimicrobial resistance among leading causes of death globally

The most comprehensive estimate of the global impact of antimicrobial resistance thus far is published in The Lancet today. It reveals that more than 1.2 million people (and potentially millions more) around the world died in 2019 as a direct result of antibiotic-resistant bacterial infections – placing it among the leading causes of death.

19 Jan 2022

‘Decoy’ protein mitigates lung damage, death induced by aggressive SARS-CoV-2 variants

A drug treatment that acts as a decoy against SARS-CoV-2 was highly effective at preventing death and lung damage in humanized animal models of severe COVID-19 disease, according to a Nature Chemical Biology study from researchers at the University of Illinois Chicago.

19 Jan 2022

Study shows inequalities in addressing post-acute neurological manifestations of COVID-19

Researchers have explored the inequities in understanding and addressing the neurological complications of COVID-19 among marginalized communities in the United States.

19 Jan 2022

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

In a new study, researchers used bioinformatics tools to explore the biological characteristics of SARS-CoV-2-infected myocardium.

19 Jan 2022

Independent drug action responsible for greater clinical efficacy of combination cancer therapies

Independent drug action, not synergy nor additivity, accounted for the clinical efficacy of nearly all examined combination therapies involving immune checkpoint inhibitors in clinical trials, according to results from a retrospective analysis.

19 Jan 2022

The latest advancements in polymer-based nanotechnology approaches used to fight against SARS-CoV-2

A recent review discusses the engineering versatility of polymeric nanoparticles - making a good therapeutic alternative against coronavirus diseases.

19 Jan 2022

New therapies for AIRDs can reduce the harmful side-effects caused by conventional treatments

New therapies for autoimmune rheumatic diseases (AIRDs) that are designed to better regulate lipid (fat) metabolism, could significantly reduce the harmful side-effects caused by conventional treatments, finds a new large-scale review led by UCL researchers.

19 Jan 2022

Macrodomains represent a unique target for pathogens with pandemic potential

In a new study published in the journal Pathogens, researchers have summarized the role of the macrodomain in viral replication and virulence and further reviewed the development of macrodomain inhibitors as antiviral agents.

18 Jan 2022

Machine learning model identifies new risk genes for motor neurone disease

Scientists have developed a new machine learning model for the discovery of genetic risk factors for diseases such as Motor Neurone Disease (MND).

18 Jan 2022

Drugs News and Research

CENTOGENE teams up with Insilico Medicine to improve therapeutic targets for Niemann-Pick disease type C

Oral supplement appears to promote muscle endurance and mitochondrial health in humans

Cancer patients receiving treatment may mount inadequate immune response to COVID-19 vaccination

Mice study identifies ventral spinocerebellar tract neurons that control locomotion

Study: Many incarcerated pregnant people with opioid use disorder do not receive standard of care treatment

Could heart rate be a risk factor for dementia?

Researchers explore furin inhibitors as a potential tool for treating COVID-19 infection

Cannabis companies flout state regulations to market products in a way that appeals to children

Variants of SARS-CoV-2 and preventive strategies

New mathematical model can calculate the risk of resistance evolution for drug pairs

Study identifies a new potential pathway for developing therapeutics against Epstein-Barr virus

A comprehensive analysis places antimicrobial resistance among leading causes of death globally

‘Decoy’ protein mitigates lung damage, death induced by aggressive SARS-CoV-2 variants

Study shows inequalities in addressing post-acute neurological manifestations of COVID-19

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

Independent drug action responsible for greater clinical efficacy of combination cancer therapies

The latest advancements in polymer-based nanotechnology approaches used to fight against SARS-CoV-2

New therapies for AIRDs can reduce the harmful side-effects caused by conventional treatments

Macrodomains represent a unique target for pathogens with pandemic potential

Machine learning model identifies new risk genes for motor neurone disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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