Genetic News and Research

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Do androgens play a role in COVID-19 severity?

Researchers assess the association between the AR polyQ polymorphism with COVID-19 severity using a large cohort of 1,136 COVID-19 male patients.

5 Apr 2022

Childhood glaucoma poses significant threat to caregiver’s quality of life

Even with more advanced treatments and early intervention, caregivers of young people living with childhood glaucoma face profound challenges with no cure or way to reverse the damage - and always facing the prospect of their child losing their sight.

5 Apr 2022

Pre-existing memory B cell dynamics during SARS-CoV-2 Omicron breakthrough infection

A new study analyzed the recall of pre-existent cross-reactive memory B cells upon the SARS-CoV-2 Omicron breakthrough infections.

5 Apr 2022

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Supporting actors sometimes steal the show. In a new study published today in Cell, researchers headed by Prof. Ido Amit at the Weizmann Institute of Science have shown that supporting cells called fibroblasts, long viewed as uniform background players, are in fact extremely varied and vital.

5 Apr 2022

“MixOmicron” SARS-CoV-2 recombinant evades variant screening

A new study describes a new variant that resembles the SARS-CoV-2 Omicron BA.21 for the most part but has a small segment at the 3’ tip that belongs to the BA.1 variant.

5 Apr 2022

Improving our understanding of a severe pregnancy sickness (Hyperemesis Gravidarum)

News-Medical talks to Dr. Marlena Fejzo about a breakthrough in the understanding of hyperemesis gravidarum, and how it could improve maternal health around the world.

5 Apr 2022

Prior COVID vaccination induces a more robust antibody response to Omicron

A recent study posted to the medRxiv* preprint server assessed the impact of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on the human immune response against SARS-CoV-2 Omicron infection.

5 Apr 2022

Framework for genomic surveillance of SARS-CoV-2 Mpro evolution

A recent study posted to the bioRxiv* preprint server investigated the active genetic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), its emerging mutations, and the existence of antiviral resistance against Mpro inhibitors like paxlovid.

5 Apr 2022

Study provides new insights into cause of metastasis in prostate cancer

Prostate cancers remain localized in the majority of cases, giving affected individuals a good chance of survival.

4 Apr 2022

Air surveillance of SARS-CoV-2 and other respiratory pathogens

A recent study posted to the medRxiv* preprint server reported severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) detection in air samples from real-world congregate settings.

4 Apr 2022

The SAVE initiative to monitor the impact of SARS-CoV-2 variants

The SAVE initiative assesses the impact of SARS-CoV-2 variants on diagnostics, vaccines, and therapies, as well as communicating public health dangers.

4 Apr 2022

Cow dung likely behind black fungus epidemic in India

Cow dung, widely used as a fuel and in rituals in India, is likely behind an epidemic of black fungus that killed or maimed thousands of patients treated in the country for COVID-19 in 2021, say medical researchers.

4 Apr 2022

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B cell signaling acts as both a red light to signaling in healthy cells and a green light to signaling in immune-deficient cells.

4 Apr 2022

Genetic risk score predicts the likelihood of cardiovascular events in people with Type 2 diabetes

A risk score based on a gene map predicted the likelihood of high blood pressure leading to heart problems or stroke in people with Type 2 diabetes, according to a study published today in the American Heart Association's peer-reviewed journal Hypertension.

4 Apr 2022

Consensus document offers recommendations on genetic testing for inherited cardiac diseases

When should patients and family members undergo genetic assessment for a heart condition? Find out in an international consensus document published in EP Europace, a journal of the European Society of Cardiology and presented at EHRA 2022, a scientific congress of the ESC.

4 Apr 2022

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Researchers examined whether varied allelic frequencies of the HLA gene in people of different ancestral origins were associated with increased susceptibility to SARS-CoV-2 infection and disease severity.

4 Apr 2022

Novel rapid genetic test could spare 14,000 newborns from lifelong hearing loss

Clinicians and nurses in neonatal intensive care units (NICU) across Manchester University NHS Foundation Trust (MFT) are the world’s first to deploy genedrive’s MT-RNR1 ID Kit, a new rapid genetic point of care test (POCT) to screen babies for the genetic variant m.1555A>G when admitted with suspected sepsis

4 Apr 2022

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

In a recent study published in the journal PLOS Genetics, researchers explored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ribonucleic acid (RNA) editing in host cells.

4 Apr 2022

Human genome sequenced in its entirety for the first time

An international team of almost one hundred scientists has uncovered the complete, gap-free human genome by deciphering the remaining and hitherto unknown sequences – opening the door for novel approaches to treat various diseases. This seminal, historical study is published in the renowned journal Science.

3 Apr 2022

Extension study shows mavacamten’s efficacy and safety in treating hypertrophic cardiomyopathy

Use of mavacamten, a novel cardiac myosin inhibitor, to treat people with symptomatic obstructive hypertrophic cardiomyopathy (HCM), a condition that results in excess thickening of the heart muscle, resulted in continued benefits in patient quality of life and outcomes over an extended period of time, according to interim data from the EXPLORER-HCM extension study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

Genetic News and Research

Do androgens play a role in COVID-19 severity?

Childhood glaucoma poses significant threat to caregiver’s quality of life

Pre-existing memory B cell dynamics during SARS-CoV-2 Omicron breakthrough infection

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

“MixOmicron” SARS-CoV-2 recombinant evades variant screening

Improving our understanding of a severe pregnancy sickness (Hyperemesis Gravidarum)

Prior COVID vaccination induces a more robust antibody response to Omicron

Framework for genomic surveillance of SARS-CoV-2 Mpro evolution

Study provides new insights into cause of metastasis in prostate cancer

Air surveillance of SARS-CoV-2 and other respiratory pathogens

The SAVE initiative to monitor the impact of SARS-CoV-2 variants

Cow dung likely behind black fungus epidemic in India

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

Genetic risk score predicts the likelihood of cardiovascular events in people with Type 2 diabetes

Consensus document offers recommendations on genetic testing for inherited cardiac diseases

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Novel rapid genetic test could spare 14,000 newborns from lifelong hearing loss

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

Human genome sequenced in its entirety for the first time

Extension study shows mavacamten’s efficacy and safety in treating hypertrophic cardiomyopathy

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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