Cell Metabolism News and Research

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Weight loss with ozempic may weaken muscles even when size remains stable

As use of the popular anti-diabetic and weight-loss drug Ozempic skyrockets, so have concerns about the medication's side effects.

5 Aug 2025

Canadian scientists trap gut microbe fuel to improve blood sugar and liver health

A team of Canadian scientists has discovered a surprising new way to improve blood sugar levels and reduce liver damage: by trapping a little-known fuel made by gut bacteria before they wreak havoc on the body.

30 Jul 2025

IRF-5 identified as key to preventing immune cell exhaustion

In fighting chronic infections or certain cancers, CD8+ T cells-the immune system's frontline soldiers-eventually become exhausted. They lose effectiveness and respond less efficiently to threats.

24 Jul 2025

New imaging technique reveals how cells organize glucose processing

In a scientific first, researchers from Vanderbilt University and the University of California, San Diego, have generated a high-resolution metabolic "map" of how cells orchestrate glucose processing, revealing a hidden world where organelles and molecular complexes collaborate when responding to a rush of nutrients.

22 Jul 2025

Improving RNA drug delivery through intracellular traffic control

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness.

1 Jul 2025

New yeast model sheds light on proteasome and mitochondrial interaction

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating the interaction between the proteasome and mitochondrial function.

30 Jun 2025

Researchers identify key nerve cells behind semaglutide's appetite reduction

A specific group of nerve cells in the brain stem appears to control how semaglutide affects appetite and weight – without causing nausea.

27 May 2025

Scientists discover unique molecular fingerprints of insulin resistance

Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes.

27 May 2025

New insights reveal EGFR as a target in KRAS-mutated colon cancer

KRAS mutations are among the most common genetic alterations in cancer and are considered particularly difficult to treat.

26 May 2025

Brain stem nerve cells hold key to safer weight loss treatments

A specific group of nerve cells in the brain stem appears to control how semaglutide affects appetite and weight - without causing nausea

23 May 2025

Acetate and gut bacteria work together to reduce obesity in mice

Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a new way to reduce obesity.

19 May 2025

Hormone FGF21 reverses fatty liver disease by signaling the brain

A pioneering research study published today in Cell Metabolism details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. The hormone works primarily by signaling the brain to improve liver function.

13 May 2025

Estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue

A new Salk Institute study suggests estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue.

12 May 2025

Tirzepatide outperforms semaglutide in weight loss clinical trial

Tirzepatide (trade name Zepbound) promoted greater weight loss in individuals with obesity than did semaglutide (trade name Wegovy) in a clinical trial that compared the safety and efficacy of the injectable drugs.

12 May 2025

DT-109 shows promise in treating atherosclerosis and liver disease

A drug candidate, previously successful at treating severe fatty liver disease, reduces atherosclerosis - a primary driver of cardiovascular death worldwide - in large mammals, a study suggests.

23 Apr 2025

Lipid metabolism as a driver of therapy resistance in triple negative breast cancer

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC).

20 Apr 2025

Study links linoleic acid to triple-negative breast cancer growth

Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat "triple negative" breast cancer subtype, according to a preclinical study led by Weill Cornell Medicine investigators.

1 Apr 2025