Crohn’s Disease News and Research

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Broccoli sprouts diet protects mice from Crohn's disease, study shows

High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life in patients with inflammatory bowel disease (IBD), according to a study conducted in mice.

9 Nov 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Lack of direct comparisons prevents assessment of upadacitinib's benefit in Crohn's disease

Like several immunosuppressive biologics, the JAK inhibitor upadacitinib is also approved for the treatment of Crohn's disease. Commissioned by the Federal Joint Committee (G-BA), the Institute for Quality and Efficiency in Health Care (IQWiG) has now investigated in an early benefit assessment whether the drug offers an added benefit versus the appropriate comparator therapy to patients with moderate to severe active Crohn's disease who have had an inadequate response, lost response or are intolerant to conventional therapy or a biologic agent.

25 Oct 2023

Does inflammatory bowel disease have a causal relationship with extracolonic tumors?

Whether inflammatory bowel disease (IBD) is causally related to extracolonic cancers.

17 Oct 2023

Beyond the gut: Crohn's disease's oral clues for timely diagnosis

The oral manifestations of CD.

12 Oct 2023

Effectiveness of Lactobacillus in treating inflammatory bowel disease

The role of Lactobacillus in treating inflammatory bowel disease.

4 Oct 2023

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

New study in Nature Medicine links yeast cells in the gastrointestinal tract to abnormal immune responses causing inflammation in Crohn's disease patients. The research suggests that these yeast-reactive T-cells could be a potential therapeutic target, offering new avenues for treatment.

27 Sep 2023

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

A recent study in the Nutrients journal employs bibliometrics to explore how nutrition impacts the relationship between gut microbiota and chronic pain. The research highlights the potential of probiotics and prebiotics in managing pain conditions and underscores the need for further studies to understand the interplay between diet, gut health, and chronic pain.

28 Aug 2023

How have inflammatory bowel disease treatments changed after the introduction of biologics?

Researchers compared changes in inflammatory bowel disease treatment strategies before and after the introduction of biologics in Japan.

24 Aug 2023

Are inflammatory bowel disease patients more at risk of colorectal cancer?

Researchers analyzed data from a large cohort of inflammatory bowel disease patients and looked at the risk and frequency of colorectal cancer.

9 Aug 2023

The effectiveness of psychological therapies in patients with inflammatory bowel disease

Psychological therapies provide short-term improvements in stress, anxiety, depression, and quality-of-life scores in patients with IBD.

8 Aug 2023

Study finds genetic overlap between IBS, gastrointestinal diseases, and psychiatric disorders

Researchers characterized the genetic architecture of IBS and investigated genetic overlap with gastrointestinal and psychiatric phenotypes.

8 Aug 2023

How do dietary patterns influence inflammatory bowel disease?

Researchers used bibliometrics to analyze studies describing the effects of dietary patterns on inflammatory bowel disease (IBD).

7 Aug 2023

Stem cells offer new hope for Crohn's disease treatment

Research from Ann & Robert H. Lurie Children's Hospital of Chicago found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn's disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage.

28 Jul 2023

Anti-inflammatory nanoparticles show promise in treating inflammatory bowel disease

Chronic inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects.

24 Jul 2023

Is constipation associated with hypertension and cardiovascular events in older Australian adults?

Scientists investigated the association between constipation and cardiovascular events such as angina, myocardial infarction, transient ischemic attack, and stroke, as well as hypertension among a representative population of elderly hospitalized patients in Australia.

11 Jul 2023

Lilly granted MHRA marketing authorization in Great Britain for a ground-breaking UC therapy

Eli Lilly and Company announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorisation (MA) for mirikizumab (OMVOH®) for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic treatment.

10 Jul 2023

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Research paper discusses the relationship between iron deficiencies and immune tolerance in patients with inflammatory bowel disease. The study shows that high cellular iron levels fostered by pentanoate, a short-chain fatty acid produced by intestinal microbiota, are necessary for the homeostasis of regulatory T cells in the intestine, and iron deficiencies in Treg can result in lethal autoimmune disease.

17 May 2023

Crohn’s disease: Symptoms, diagnosis, and treatments

Anyone newly diagnosed with Crohn's disease likely has a lot of questions – and probably some anxiety – about having a chronic ailment for which there's no cure.

4 May 2023

Newly discovered genetic variant increases risk of developing perianal Crohn's disease

Cedars-Sinai investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease.

20 Apr 2023