DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

Researchers identify a distinct immuno-inflammatory biomarker across major psychiatric disorders

Individuals with psychiatric disorders exhibiting seemingly similar symptoms often respond very differently to the same treatment, suggesting that distinct biological processes are at work beneath the surface of similar clinical presentations.

11 Dec 2025

Researchers discover new biomarker of "complicated" mild- to severe-pediatric traumatic brain injury

Researchers at the University of Pittsburgh and UPMC Children's Hospital of Pittsburgh discovered a promising new biomarker of "complicated" mild- to severe-pediatric traumatic brain injury, or TBI.

9 Dec 2025

New analysis reveals fundamental flaws in widely used measures of biological aging

A landmark review published today in Genomic Psychiatry challenges researchers to fundamentally reconsider how the field measures and conceptualizes biological aging.

3 Dec 2025

Epigenetic drift explains why the aging intestine becomes more vulnerable to cancer

Researchers from the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology Centre (MBC) in Turin and the University of Turin, Italy, have discovered a fundamental mechanism of aging in the gut.

28 Nov 2025

Researchers uncover how a key transcription factor reads DNA in human cells

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells.

26 Nov 2025

Discovery of sequence-driven DNA methylation offers new path for epigenetic engineering

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics-meticulously placed chemical tags that influence which genes are expressed in each cell.

22 Nov 2025

Schizophrenia risk detectable at birth through epigenetic signatures

Genetic susceptibility to neurodevelopmental conditions such as schizophrenia, autism, and ADHD can be linked, in part, to distinct epigenetic signatures in newborn cord blood.

17 Nov 2025

Maternal type 1 diabetes may protect children from developing the disease

Findings suggest maternal T1D exposure leads to protective epigenetic alterations in children, influencing immune response and type 1 diabetes susceptibility.

10 Nov 2025

Maternal type 1 diabetes confers a protective effect in children through epigenetic programming

Children with a family history of type 1 diabetes (T1D) have an increased risk of developing the disease.

6 Nov 2025

Study finds high intake of ultra-processed foods tied to reduced DNA methylation

Women who consumed more ultra-processed foods (UPFs) showed distinct DNA methylation patterns, mostly reduced across key gene regions. These exploratory findings suggest that high UPF intake may influence gene regulation through epigenetic mechanisms.

4 Nov 2025

AI-powered LifeClock forecasts diseases years before symptoms appear

Researchers have developed LifeClock, an AI-driven biological clock trained on over 24 million electronic health records to estimate biological age across the human lifespan. The model accurately predicts disease risk years in advance, revealing distinct developmental and aging processes.

28 Oct 2025

Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding

Maternal peanut and peanut butter consumption during pregnancy and breastfeeding shaped DNA methylation patterns in children, particularly in genes regulating neurodevelopment and inflammation. These findings suggest maternal diet can prime offspring epigenetic sensitivity to breastfeeding duration.

27 Oct 2025

Prenatal air pollution exposure tied to higher autism risk in children

A population-based study of over two million births in Ontario found that prenatal exposure to the sulfate and ammonium components of fine particulate matter (PM₂.₅) was associated with a higher risk of autism spectrum disorder. The risk was greatest during mid to late pregnancy and among infants in urban, lower-income neighborhoods.

26 Oct 2025

Researchers reveal how maternal stress reshapes fetal growth and brain development

Maternal stress, encompassing physical, emotional, and psychological distress, remains a widespread yet underestimated risk during pregnancy.

24 Oct 2025

Review reveals how paternal lifestyle shapes sperm epigenetics and offspring health

A new review in Clinical Epigenetics synthesises growing evidence that paternal lifestyle and environmental exposures such as diet, obesity, smoking, endocrine-disrupting chemicals, and stress alter sperm epigenetic marks (DNA methylation, histone retention, and small non-coding RNAs).

17 Oct 2025

Blood test shows promise for faster ALS diagnosis

New research by UCLA Health has found a simple blood test could provide faster and more accurate diagnosis of ALS by measuring cell-free DNA.

15 Oct 2025

Child maltreatment leaves measurable biological scars on children's DNA

Child maltreatment, which includes abuse and neglect, is one of the most serious public health concerns worldwide.

15 Oct 2025

Could belonging be a biological shield? Researchers uncover aging clues

Researchers analyzing over 2,100 adults from the MIDUS cohort found that individuals with higher cumulative social advantage, spanning community ties, family relationships, and religious support, showed slower biological aging and lower systemic inflammation. The findings suggest that long-term social resources may become biologically embedded, influencing molecular pathways linked to longevity.

12 Oct 2025

Air pollution plays a significant role in the development of metabolic disorders

Long-term exposure to fine air pollution can impair metabolic health by disrupting the normal function of brown fat in mice. A study co-led by the University of Zurich shows that this occurs through complex changes in gene regulation driven by epigenetic mechanisms.

9 Oct 2025

Tagomics publishes a new approach to genome-wide epigenomic profiling

Tagomics Ltd., a pioneering biomarker discovery and diagnostics company, today announced the publication of a peer-reviewed study in Cell Reports Methods, underpinning its epigenomic profiling technology, Active-Seq, the basis of Tagomics' Activace™ platform.

30 Sep 2025

DNA Methylation News and Research

Further Reading

Researchers identify a distinct immuno-inflammatory biomarker across major psychiatric disorders

Researchers discover new biomarker of "complicated" mild- to severe-pediatric traumatic brain injury

New analysis reveals fundamental flaws in widely used measures of biological aging

Epigenetic drift explains why the aging intestine becomes more vulnerable to cancer

Researchers uncover how a key transcription factor reads DNA in human cells

Discovery of sequence-driven DNA methylation offers new path for epigenetic engineering

Schizophrenia risk detectable at birth through epigenetic signatures

Maternal type 1 diabetes may protect children from developing the disease

Maternal type 1 diabetes confers a protective effect in children through epigenetic programming

Study finds high intake of ultra-processed foods tied to reduced DNA methylation

AI-powered LifeClock forecasts diseases years before symptoms appear

Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding

Prenatal air pollution exposure tied to higher autism risk in children

Researchers reveal how maternal stress reshapes fetal growth and brain development

Review reveals how paternal lifestyle shapes sperm epigenetics and offspring health

Blood test shows promise for faster ALS diagnosis

Child maltreatment leaves measurable biological scars on children's DNA

Could belonging be a biological shield? Researchers uncover aging clues

Air pollution plays a significant role in the development of metabolic disorders

Tagomics publishes a new approach to genome-wide epigenomic profiling

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