Endonuclease News and Research

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High mobility group (HMG) genes and cancer: an interview with Dr. Linda Resar, Johns Hopkins University School of Medicine

High mobility group A genes are highly expressed in all aggressive cancers studied to date. These genes encode the high mobility group A (HMGA) proteins. In other words, these genes provide the genetic “code” necessary to produce HMGA proteins.

8 Aug 2013

Treatment with Lfcin4-14 reduces DNA damage in colon cancer cells exposed to UV light

Milk consumption has been linked to improved health, with decreased risks of diabetes, metabolic syndrome, and colon cancer. A group of scientists in Sweden found that lactoferricin4-14 (Lfcin4-14), a milk protein with known health effects, significantly reduces the growth rate of colon cancer cells over time by prolonging the period of the cell cycle before chromosomes are replicated. In a new study, investigators report that treatment with Lfcin4-14 reduced DNA damage in colon cancer cells exposed to ultraviolet (UV) light.

4 Oct 2012

Drug molecules designed for influenza may be adapted to treat other viruses

St. Jude Children's Research Hospital study shows how compounds blocking an enzyme universal to all influenza viruses may allow development of new antiviral drugs that also avoid the problem of drug resistance

3 Aug 2012

FEN1 enzyme might serve as anti-cancer therapy target

An enzyme essential for DNA replication and repair in humans works in a way that might be exploited as anti-cancer therapy, say researchers at The Scripps Research Institute and Lawrence Berkeley National Laboratory.

15 Apr 2011

Innovative method for in-cell gene manipulation

A cross-disciplinary Small Medicine and Advanced Research Translation (SMART) team led by Prof. Dar-Bin Shieh of Institute of Oral Medicine in Medical College at National Cheng Kung University (NCKU), Tainan, Taiwan, has announced a breakthrough in the precision in-cell gene scission at pre-designed sequence sites using Artificial Targeting Light Activated Nano Scissors (ATLANS) and a custom build photonic device.

9 Nov 2010

Transgenomic expands EU distribution of SURVEYOR Scan K-RAS CE IVD mutation detection kit

Transgenomic, Inc. today announced that it completed the requirements for CE IVD labeling and has significantly expanded distribution of its SURVEYOR® Scan K-RAS mutation detection kit throughout most of the European Union. The SURVEYOR Scan K-RAS CE IVD kit is a member of Transgenomic's family of mutation detection kits, which features proprietary SURVEYOR endonuclease technology.

14 Sep 2010

PharmaMar presents new trials with Yondelis, Zalypsis and Irvalec anti-tumor drugs at 101st AACR meeting

PharmaMar, a biopharmaceutical company owned by Grupo Zeltia (ZEL.MC), presented six new trials with marine-based anti-tumor drugs Yondelis(R), Zalypsis(R) and Irvalec(R) at the American Association for Cancer Research's (AACR) 101st Annual Meeting, held in Washington, D.C. from April 17-21.

22 Apr 2010

U.S. PTO to reexamine the patents in Cellectis-Precision BioSciences litigation

Precision BioSciences, Inc. today announced that the United States Patent and Trademark Office (PTO) has granted Precision’s requests for inter partes reexamination of U.S. Patent Nos. 6,610,545 (the ‘545 patent) and 7,309,605 (the ‘605 patent), which Cellectis SA (Alternext: ALCLS) has asserted against Precision in litigation.

29 Sep 2009

Just a little squeeze lets proteins assess DNA

To find its target, all a protein needs to do is give quick squeezes as it moves along the DNA strand, suggests new research from The University of Arizona in Tucson.

16 Dec 2008

Discovery on human individuality and maternal and paternal DNA

Have you ever wondered why you inherited your mother's smile but not your father's height?

18 Oct 2007

Directed nanoparticles deliver gene therapy

After binding DNA segments to tiny iron-containing spheres called nanoparticles, researchers have used magnetic fields to direct the nanoparticles into arterial muscle cells, where the DNA could have a therapeutic effect.

31 Jul 2007

Ago2 and hematopoiesis

Argonaute 2 (Ago2) is unique among its family: It is the only one of the four mammalian Argonaute proteins that exhibits endonuclease 'slicer' activity (facilitation of miRNA-guided cleavage of target mRNA).

12 Jul 2007

Transgenomic signs contract with OSI Pharmaceuticals for cancer genetic analysis

Transgenomic has announced that it has signed a contract with OSI Pharmaceuticals to complete an analysis of specific cancer pathway genes.

11 Apr 2007

Scientists identify specific enzymes that make meningitis hard to fight

Two enzymes in meningitis bacteria which prevent the body from successfully fighting off the disease, and make the infection extremely virulent, have been identified in new research published today.

22 Feb 2007

Removing a gene involved in repairing damaged DNA causes metabolic syndrome

Removing a gene involved in repairing damaged DNA causes mice to develop the metabolic syndrome, researchers at Oregon Health & Science University have discovered.

21 Feb 2006

Research sheds light on origins of "junk" DNA

In experiments with transgenic mice, University of Pennsylvania School of Medicine researchers discovered the remaining steps in the complicated process of how the largest class of jumping genes replicates and inserts themselves within the human genome.

7 Feb 2006

Exploiting biology's own chemical toolbox...

Exploiting biology's own chemical toolbox, researchers have developed a new technique that will allow them to modify specific sequences within a DNA molecule. The approach will not only help reveal the impact of biochemical alterations to DNA, but could have far-reaching implications for DNA-based medical diagnosis and nanobiotechnology.

28 Nov 2005