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Ageing slows brain protein clearance and shifts synaptic waste to microglia

Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.

22 Jan 2026

Study shows DHPS enzyme controls macrophage maturation across multiple organs

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health found that an enzyme involved in protein translation is essential for circulating immune cells, called monocytes, to mature into tissue-resident macrophages, a specialized population of immune cells that maintain organ health by clearing dead cells and debris.

21 Jan 2026

Suppressing brain immune cells enhances memory recall in young mice

Babies of every species from mouse to human rapidly forget things that happen to them-an effect called infantile amnesia.

20 Jan 2026

Blocking microglia can prevent infantile amnesia

Scientists have found that blocking microglia (specialist immune cells in the brain) prevents infant forgetting ("infantile amnesia") and improves memory in mice, suggesting that microglia may actively manage memory formation and dictate what, and when, we forget.

20 Jan 2026

Study reveals how ketogenic diet protects against epilepsy seizures

University of Virginia School of Medicine researchers have revealed how the popular, low-carb ketogenic diet protects against epilepsy seizures and possibly neurodegenerative diseases such as Alzheimer's and Parkinson's.

16 Jan 2026

Study reveals genetic signatures linked to HIV-related cognitive impairment

Using participant skin cells reprogrammed into neurons, Weill Cornell Medicine researchers have identified genetic signatures associated with HIV infection that may contribute to the cognitive impairment that often occurs in people living with HIV, even when the virus is controlled.

14 Jan 2026

Single-cell analysis reveals gene disruptions in early-onset Alzheimer's brain regions

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to reveal disruptions in gene function in three brain regions of patients with sporadic early onset Alzheimer's disease.

13 Jan 2026

Brain immune cells drive persistent negative emotions after repeated binge drinking

New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying driver of prolonged negative feelings caused by repeated, sustained binge drinking (binge exposure).

12 Jan 2026

Injectable nanomaterial reduces secondary brain injury after ischemic stroke

When a person suffers a stroke, physicians must restore blood flow to the brain as quickly as possible to save their life.

7 Jan 2026

Microglia help protect the spinal cord from age-related damage

Researchers at Karolinska Institutet have discovered that the nervous system's own immune cells help protect the spinal cord from age-related damage.

7 Jan 2026

The gut is not just digestive and new evidence shows it actively controls brain function

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

6 Jan 2026

Researchers explore why Alzheimer's affects men and women differently

More than seven million Americans have Alzheimer's disease, and two-thirds of them are women, according to the Alzheimer's Association. The O'Banion Lab at the Del Monte Institute for Neuroscience at the University of Rochester has long been studying this disease and is looking more closely at the differences between male and female brains.

30 Dec 2025