Plasmodium falciparum News and Research

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How frequent was SARS-CoV-2 and malaria co-infection during the first wave of the pandemic?

Researchers determined the prevalence of circulating SARS-CoV-2 variants and the frequency of co-occurrence of COVID-19 and malaria in Burkina Faso, West Africa.

22 Sep 2022

R21/Matrix-M booster maintains high efficacy against first and multiple episodes of clinical malaria

The phase 1/2b clinical trial on R21/Matrix-M malaria vaccine has recently reported the safety and efficacy of booster vaccination at 12 months.

15 Sep 2022

Experimental, genetically attenuated malaria vaccine warrants further exploration

Findings from a preliminary human study of an experimental, genetically attenuated malaria parasite immunization show this vaccine warrants further exploration.

24 Aug 2022

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Researchers have created a mathematical model to predict genetic resistance to antimalarial drugs in Africa to manage one of the biggest threats to global malarial control.

12 Aug 2022

New way to test vaccines may be as rigorous and stringent as exposure to field strains of malaria

Malaria is the deadliest mosquito-borne parasitic infection of humans. In 2021, after a century of research, the World Health Organization (WHO) approved the world's first malaria vaccine.

20 Jul 2022

Identifying new chemicals with greater effectiveness, safety than quisinostat

Announcing a new review article publication for Acta Materia Medica journal. In this article the authors use medicinal chemistry methods to identify new chemical entities with greater effectiveness and safety than quisinostat.

17 May 2022

Malaria eradication calls for detection and treatment of asymptomatic cases

Asymptomatic malaria infections do not reduce the risk of severe disease, as widely believed, but suppress the immune system and prevent it from getting rid of parasites that persist in the bloodstream, research suggests.

16 May 2022

Crucial discovery could inform potential strategies to control malaria transmission

WEHI researchers in Melbourne have made a crucial discovery about how asymptomatic malaria infections impact the body, informing potential strategies to control transmission and improve treatment outcomes.

5 May 2022

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

As part of World Malaria Day 2022, we interview Karine Le Roch PH.D., about her latest research into how novel antimalarial therapeutic strategies could be on the horizon, after identifying two proteins that are critical to the survival of the malaria parasite, Plasmodium falciparum.

25 Apr 2022

Scientists are searching for the ‘perfect protein’ to develop mRNA-based malaria vaccine

After the success of mRNA vaccines against COVID-19, scientists are cautiously optimistic that the same technology can be used to tackle other widespread diseases such as malaria.

7 Apr 2022

Crucial regulator of malaria parasite transmission identified

Malaria remains one of the biggest global public health challenges. It kills a young child every two minutes, more than any other infectious disease.

25 Feb 2022

Research shows a relationship between increased SARS-CoV-2 seroreactivity and antimalarial humoral immunity

Researchers investigate the cross-reactivity of the SARS-CoV-2 with pre-pandemic malaria-exposed sera samples collected from Cambodia.

19 Jan 2022

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Malaria is one of the most dangerous infectious diseases. The causative pathogens are microorganisms of the genus Plasmodium.

29 Nov 2021

Examining the effects of malaria parasites on global health

News-Medical speaks to Professor Kevin Baird about his lifelong research into malaria and how another malaria parasite, P. Vivax, is taking a toll on global health.

22 Nov 2021

New findings about naturally acquired immunity may help improve existing malaria vaccines

When you have become immune to malaria after having contracted the disease, it seems that the body uses a more efficient protection than if you have been vaccinated against the deadly disease.

12 Nov 2021

Single-genome sequencing reveals malaria parasite genetics and evolution

Understanding how malaria parasites evolve after a human is bitten by an infected mosquito is very difficult. There can be billions of individual parasites in a patient's bloodstream and traditional genetic sequencing techniques can't identify the raw material for evolution: new mutations.

12 Oct 2021

Second most common malaria parasite causes unrecognized burden on global health

The malaria parasite Plasmodium vivax (P. vivax) causes frequent, chronic infections that represent a major unrecognized burden on global health, according to a review by Kevin Baird of the Eijkman-Oxford Clinical Research Unit in Indonesia and Katherine Battle of the Institute for Disease Modeling in the United States publishing October 7th in the open access journal PLOS Medicine.

8 Oct 2021

New vaccine platform can better induce anti-malaria immunity in the liver

Malaria remains a deadly disease that affects people worldwide, particularly in Africa. Caused by a parasite that can enter the human bloodstream via mosquito bite, the parasites can then infect and reproduce within the person's liver.

16 Sep 2021

Designing antimalarials with multiple targeting mechanisms of action

Malaria remains a serious global health threat. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance.

18 Aug 2021

Two chemoattenuated PfSPZ malaria vaccines provide strong and lasting protection

A team of researchers recently optimized regimens for CVac, wherein aseptic, purified, cryopreserved, and infectious PfSPZ were inoculated and mixed with PYR and CQ.

5 Jul 2021