Progenitor Cells News and Research

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New method yields up to twice as many therapeutic myogenic cells as previous protocols

If cancer is a disease of overabundance, where cells divide without restraint and tumors grow despite the body's best interests, then degenerative diseases are disorders of deprivation.

30 Oct 2025

New stem cell-based strategy could enhance neuronal regeneration and neuroplasticity

The brain's mechanisms for repairing injuries caused by trauma or degenerative diseases are not yet known in detail.

14 Oct 2025

Breakthrough in building functional synthetic kidneys using assembloids

A USC Stem Cell-led research team has achieved a major step forward in the effort to build mouse and human synthetic kidneys.

17 Sep 2025

Novel vitamin K analogs show promise for reversing neurodegenerative diseases

Neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's disease are characterized by the progressive loss of neurons.

13 Sep 2025

Lung tumors rewire immune cells in the bone marrow before they reach cancer sites

Lung tumors don't just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy

10 Sep 2025

Spaceflight accelerates aging of human blood stem cells

Researchers from University of California San Diego Sanford Stem Cell Institute have discovered that spaceflight accelerates the aging of human hematopoietic stem and progenitor cells (HSPCs), which are vital for blood and immune system health.

4 Sep 2025

Estrogen supports kidney regeneration and protects women from chronic disease

A new study in mice provides insights into why females in their reproductive years appear to be relatively protected from chronic kidney disease, a leading public health concern.

4 Sep 2025

Why metformin could protect the brain by rewiring mitochondria

Metformin boosts human oligodendrocyte differentiation and myelination across stem-cell, organoid, and chimera models. The study links these effects to mitochondrial metabolic shifts, supporting its potential as a therapy for multiple sclerosis.

1 Sep 2025

Clonogenic hepatocytes identified as engines of liver development

In a new study published in the Journal of Hepatology, researchers from the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) show that only 15–20% of hepatocytes in newborn mice - dubbed clonogenic hepatocytes - are responsible for generating over 90% of the adult liver mass.

29 Aug 2025

Signaling mechanisms driving olfactory neurogenesis in zebrafish

Cellular differentiation of stem cells into specialized cells requires many steps, including division, to create more cells; fate determination, which is a commitment to a specific lineage or developmental path; and migration, to integrate the cell into its final location.

29 Aug 2025

Groundbreaking approach combines 3D printing and stem cell biology for spinal cord injury recovery

For the first time, a research team at the University of Minnesota Twin Cities demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery.

25 Aug 2025

SOX2 drives progression and therapy resistance in advanced prostate cancer

Prostate cancer remains a global health challenge, ranking as the second most common malignancy among men.

22 Aug 2025

Computational approach provides insight into neural progenitor cells and their role in brain disorders

For much of the 20th century it was thought that the adult brain was incapable of regeneration. This view has since shifted dramatically and neurogenesis – the birth of new neurons – is now a widely accepted phenomenon in the adult brain, offering promising avenues for treating many neurological conditions.

21 Aug 2025

Exploring the complex origins of endothelial cells in tumor angiogenesis

This newly published review article offers a comprehensive examination of the complexities of tumor angiogenesis and the origins of endothelial cells (ECs) within tumors.

18 Aug 2025

GIPR signaling opens brain’s gate for GLP-1 weight-loss therapy

A Cell Metabolism study reveals that GIPR signaling in oligodendrocytes enhances brain access and weight-loss efficacy of GLP-1R agonists by increasing vascular permeability and targeting appetite-regulating neurons. This mechanism may explain why GIPR/GLP-1R co-agonists outperform single-agent therapies.

14 Aug 2025

New research sheds light on what makes the human brain unique

Research from scientists at University of California San Diego School of Medicine have shed new light on an age-old question: what makes the human brain unique?

13 Aug 2025

PDGFRA+ progenitors identified as key players in angiogenesis and periodontal tissue repair

Stem cell research, alongside the rapidly advancing field of biotechnology, has led to remarkable innovations in regenerative medicine.

5 Aug 2025

Gfi1 regulates exhausted CD8+ T cells to improve cancer immunotherapy

Killer immune cells destroy cancer cells and cells infected by virus. These CD8+ T cells are activated after detection of viral infection or growth of "non-self" tumor cells.

5 Aug 2025

Young human serum requires bone marrow for skin rejuvenation effects

A new research paper featured on the cover of Volume 17, Issue 7 of Aging (Aging-US) was published on July 25, 2025, titled "Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system."

1 Aug 2025

Vanderbilt team explores functional β-cell enhancement for diabetes

If it has seemed like more people you know are developing diabetes, you are right. The diabetes epidemic is not called that for nothing: According to the American Diabetes Association, over 10 percent of the U.S. population-approximately 38.4 million people-had diabetes in 2021, and 1.2 million more people get diagnosed each year.

30 Jul 2025