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POET-II trial reduces antibiotic duration for infective endocarditis by two weeks

A response-tailored strategy reduced antibiotic duration by two weeks without compromising the safety of patients with left-sided infective endocarditis.

28 Aug 2026

Oral anticoagulants benefit patients with atrial fibrillation at intermediate stroke risk

Oral anticoagulant therapy lowered the risk of adverse clinical events compared with no anticoagulation in patients with atrial fibrillation at intermediate stroke risk, according to results from the SINGLE-AF trial presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

28 Aug 2026

Younger heart patients benefit from implantable cardioverter-defibrillators in CMR GUIDE trial

An implantable cardioverter-defibrillator did not improve the primary endpoint overall in the CMR GUIDE trial but younger patients appeared to benefit, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in JAMA.

28 Aug 2026

UCSF scientists build largest molecular interaction map for autism

For more than two decades, researchers have identified hundreds of genes that increase the risk of autism spectrum disorder (ASD).

28 Aug 2026

CARDIO-TTRansform trial investigating eplontersen fails to meet primary efficacy endpoint

The CARDIO-TTRansform trial investigating eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy did not meet its primary efficacy endpoint, according to results presented in a Hot Line session today at ESC Congress 2026.

28 Aug 2026

First joint guidelines address cardiovascular events and chronic kidney disease

The first-ever European Society of Cardiology Guidelines on the management of cardiovascular disease and chronic kidney disease have been developed in collaboration with the European Renal Association.

28 Aug 2026

New guidelines simplify heart failure phenotypes into two groups

Reflecting improved understanding and treatment advances, new European Society of Cardiology (ESC) Guidelines on heart failure have been published online today in the European Heart Journal and will be presented at ESC Congress 2026 this afternoon.

28 Aug 2026

Probiotics for mental health? A new review finds promising signals and major gaps

This narrative review examines how psychobiotics may influence anxiety, depression, bipolar disorder, and schizophrenia through gut-brain pathways involving neurotransmitters, inflammation, immune regulation, gut barrier function, and stress signaling. Specific Lactobacillus and Bifidobacterium strains showed encouraging effects, but wide differences in strains, doses, populations, and study designs currently limit clinical translation.

28 Aug 2026

Blood-brain barrier-crossing blood pressure drugs linked to lower dementia risk

In a large Australian cohort of adults with hypertension, use of blood-brain barrier-crossing antihypertensive medications was associated with a lower risk of dementia and mortality than use of non-crossing drugs. The association was strongest for beta-blockers and angiotensin II receptor blockers, although the observational design means the findings cannot establish causality.

27 Aug 2026

Early rasburicase treatment linked to better outcomes in tumor lysis syndrome

Tumor lysis syndrome (TLS) is a life-threatening emergency that occurs when large numbers of cancer cells break down rapidly, releasing substances such as uric acid into the bloodstream that can damage the kidneys and cause serious complications.

27 Aug 2026

$15 million trial aims to improve treatment decisions for older AML patients

A newly funded national clinical trial initiative will gather critical evidence to determine the best treatment strategies for older adults with acute myeloid leukemia (AML), an aggressive, fast-moving blood cancer that leaves a substantial proportion of older patients facing uncertainty about whether to proceed to stem cell transplantation or continue non-transplant therapy.

27 Aug 2026

Study reveals how SGLT2 inhibitors improve failing heart function

Researchers have discovered that SGLT2 inhibitors, a class of drugs originally developed to treat diabetes and now widely used for heart failure, work by activating a key enzyme that helps heart cells produce and use energy more efficiently.

27 Aug 2026

HRT linked to lower dementia risk, but timing and menopause type matter

In a UK Biobank study of 183,450 postmenopausal women followed for an average of 13.3 years, hormone replacement therapy use was associated with a modestly lower risk of dementia, with stronger associations in women who had surgical menopause or shorter natural estrogen exposure. The relationship also varied by age at HRT initiation, while the observational design means the findings cannot establish that HRT prevents dementia.

27 Aug 2026

Unexpected discovery points to a possible route for childhood brain tumor treatments

When researchers at Lund University investigated how the molecule UM171 works, a molecule used to make blood stem cells multiply, they made an unexpected connection.

27 Aug 2026

CAR T-cell therapy successfully reverses severe rheumatoid arthritis

Immunotherapies such as CAR T-cell therapy are used primarily to treat cancer. In the future, these patient-specific therapies, manufactured from patients' own immune cells, could also help cure autoimmune diseases.

27 Aug 2026

Scalable stem cell method advances off-the-shelf CAR-T therapies

Researchers at the Center for Regenerative Medicine (CReM) at Boston Medical Center (BMC) and Boston University (BU) have developed a scalable method for generating CD4+ helper T cells from induced pluripotent stem cells (iPSCs), overcoming a longstanding challenge in the development of stem cell-based immunotherapies.

27 Aug 2026

Ketogenic diet provides greatest health benefits for treating obesity

A diet that severely limits carbohydrates but is high in fat has the greatest health benefits for people with obesity compared to a Mediterranean diet or a low-fat diet, according to a clinical trial publishing August 27 in the Cell Press journal Cell Metabolism.

27 Aug 2026

Brain organoids reveal how Alu-mediated gene deletion can lead to neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice.

27 Aug 2026

Women with shorter reproductive lifespan face higher risk of developing bronchiectasis

Women with a shorter reproductive lifespan are at greater risk of developing bronchiectasis, according to a new study in the July 2026 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open access journal.

27 Aug 2026

New injectable microgel system delivers precise radiation to keloids

Researchers in Korea are developing a new approach to localized brachytherapy that could improve the treatment of keloid scars.

27 Aug 2026

Therapy News and Research

POET-II trial reduces antibiotic duration for infective endocarditis by two weeks

Oral anticoagulants benefit patients with atrial fibrillation at intermediate stroke risk

Younger heart patients benefit from implantable cardioverter-defibrillators in CMR GUIDE trial

UCSF scientists build largest molecular interaction map for autism

CARDIO-TTRansform trial investigating eplontersen fails to meet primary efficacy endpoint

First joint guidelines address cardiovascular events and chronic kidney disease

New guidelines simplify heart failure phenotypes into two groups

Probiotics for mental health? A new review finds promising signals and major gaps

Blood-brain barrier-crossing blood pressure drugs linked to lower dementia risk

Early rasburicase treatment linked to better outcomes in tumor lysis syndrome

$15 million trial aims to improve treatment decisions for older AML patients

Study reveals how SGLT2 inhibitors improve failing heart function

HRT linked to lower dementia risk, but timing and menopause type matter

Unexpected discovery points to a possible route for childhood brain tumor treatments

CAR T-cell therapy successfully reverses severe rheumatoid arthritis

Scalable stem cell method advances off-the-shelf CAR-T therapies

Ketogenic diet provides greatest health benefits for treating obesity

Brain organoids reveal how Alu-mediated gene deletion can lead to neurodegeneration

Women with shorter reproductive lifespan face higher risk of developing bronchiectasis

New injectable microgel system delivers precise radiation to keloids

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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