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Leica Microsystems launches new camera for imaging live cells under near-native conditions

Leica Microsystems launches the Leica DFC9000, a monochrome microscope camera with a highly sensitive third-generation sCMOS sensor. The camera enables researchers to image live cells under near-native conditions, allowing them to gain a better understanding of cellular processes and dynamics.

From Leica Microsystems GmbH 12 Apr 2016

Immune cell with 'Superman' power could lead to novel therapies for type 1 diabetes

A new study led by scientists at The Scripps Research Institute (TSRI) reveals a previously unknown type of immune cell. The discovery opens new avenues in the effort to develop novel therapies for autoimmune diseases such as type 1 diabetes.

6 Apr 2016

Scientists identify RingoA protein as key regulator of meiosis

Published today in Nature Communications, a study by scientists at the Institute for Research in Biomedicine headed by ICREA researcher Angel R. Nebreda has reported that the protein RingoA is a key regulator of meiosis--the cell division process that gives rise to ovules and sperm for sexual reproduction in mammals.

31 Mar 2016

UT Southwestern scientists discover mutation that causes X-linked reticulate pigmentary disorder

UT Southwestern Medical Center researchers have discovered a mutation that causes a rare systemic disorder known as X-linked reticulate pigmentary disorder (XLPDR) and, significantly, the unexpected cellular mechanism by which the mutation causes the disease.

29 Mar 2016

High-throughput RNA interference screen identifies potential drug target against henipaviruses

The closely related Hendra and Nipah viruses (referred to jointly as henipaviruses) are deadly cousins of the more common mumps, measles, and respiratory syncytial viruses, all members of the paramyxovirus family. Henipavirus outbreaks are on the rise, but little is known about them, partly because research has to be conducted under extreme level containment conditions.

28 Mar 2016

UC Berkeley biologists discover potential target for unisex contraceptives

UC Berkeley biologists have discovered the switch that triggers the power kick sperm use to penetrate and fertilize a human egg, uncovering a possible source of male infertility but also a potential target for contraceptives that work in both men and women.

26 Mar 2016

DNA sequence features predict genome-wide binding pattern of key protein involved in brain disorders

Researchers from the University of Illinois at Urbana-Champaign and the University of California-Davis are combining in vivo experimentation with computation for highly accurate prediction of the genome-wide binding pattern of a key protein involved in brain disorders.

25 Mar 2016

Self-repairing cancer cells: A new pathway for cancer treatment

With narrow bodies and no collarbones, mice are able to squeeze through holes as small as a quarter-inch in diameter. Cancer cells similarly are able to migrate through extremely tight quarters but with a major difference: The journey often comes at a price - the deformation and, in some cases, rupture of the outer lining of a cell's nucleus. While deformation and rupture can sometimes lead to cell death, the cell - about 90 percent of the time - also has the ability to repair itself.

25 Mar 2016

Defective PTCHD1 gene in brain creates symptoms associated with autism and ADHD

Evidence is mounting that a gene called PTCHD1 helps the brain sort between important sights and sounds — and distractions. This gene is active in a brain region that attaches more attention to a conversation with your boss, for instance, than to an air conditioner buzzing in the background.

24 Mar 2016

New type of nerve cells appears to control feeding behaviors in mice

While researching the brain's learning and memory system, scientists at Johns Hopkins say they stumbled upon a new type of nerve cell that seems to control feeding behaviors in mice. The finding, they report, adds significant detail to the way brains tell animals when to stop eating and, if confirmed in humans, could lead to new tools for fighting obesity. Details of the study will be published by the journal Science on March 18.

20 Mar 2016

UT Southwestern researchers identify new role for protein linked to neurological disorders and cancers

Researchers at UT Southwestern Medical Center have identified a second role for a class of RNA-binding proteins, revealing new insights about neurological diseases and conditions associated with this protein such as autism, epilepsy, and certain types of cancer.

18 Mar 2016

UC San Diego researchers use CRISPR-Cas9 system to target RNA in living cells for first time ever

The genetic code stored in DNA determines everything from the color of our eyes to our susceptibility to disease. This has motivated scientists to sequence the human genome and develop ways to alter the genetic code, but many diseases are linked to a different fundamental molecule: RNA.

18 Mar 2016

New drug could transform treatment of metastatic triple negative breast cancer

A team of investigators from Houston Methodist Research Institute may have transformed the treatment of metastatic triple negative breast cancer by creating the first drug to successfully eliminate lung metastases in mice.

15 Mar 2016

Could environmental toxins trigger amyloid plaques in the brain? An interview with Dr Paul Alan Cox

Many Chamorro villagers on the island of Guam perished from a puzzling paralytic disease that combines aspects of ALS, Alzheimer's, and Parkinson's disease.

From Huron Technologies 14 Mar 2016

Scientists discover brain mechanisms that separate food consumption from cravings

Researchers investigating eating disorders often study chemical and neurological functions in the brain to discover clues to overeating. Understanding non-homeostatic eating -- or eating that is driven more by palatability, habit and food cues -- and how it works in the brain may help neuroscientists determine how to control cravings, maintain healthier weights and promote healthier lifestyles. Scientists at the University of Missouri recently discovered the chemical circuits and mechanisms in the brain that separate food consumption from cravings. Knowing more about these mechanisms could help researchers develop drugs that reduce overeating.

9 Mar 2016

First atomic-scale view of interaction between HIV capsid and host protein cyclophilin A

A new study offers the first atomic-scale view of an interaction between the HIV capsid - the protein coat that shepherds HIV into the nucleus of human cells - and a host protein known as cyclophilin A. This interaction is key to HIV infection, researchers say.

7 Mar 2016

Unlocking H5N1 virus replication: an interview with Martin Blackledge

We were able to show that one small domain of the polymerase, the part that is essential for entry of a piece of the polymerase into the cell nucleus, changes its conformation to allow it to interact with the transporter protein than takes it into the nucleus.

3 Mar 2016

New research sheds light on circadian rhythms

New research sheds light on how the rhythms of daily life are encoded in the brain. Scientists at Washington University School of Medicine in St. Louis have discovered that different groups of neurons, those charged with keeping time, become active at different times of day despite being on the same molecular clock.

3 Mar 2016

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

When the heart begins to fail, the body does everything in its power to fix the situation. But sometimes, those compensatory mechanisms ultimately do more harm than good. Such is the case with the adrenal hormone aldosterone, which stimulates the heart to pump harder, causing greater damage to the heart muscle.

3 Mar 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

Cell Nucleus News and Research

Leica Microsystems launches new camera for imaging live cells under near-native conditions

Immune cell with 'Superman' power could lead to novel therapies for type 1 diabetes

Scientists identify RingoA protein as key regulator of meiosis

UT Southwestern scientists discover mutation that causes X-linked reticulate pigmentary disorder

High-throughput RNA interference screen identifies potential drug target against henipaviruses

UC Berkeley biologists discover potential target for unisex contraceptives

DNA sequence features predict genome-wide binding pattern of key protein involved in brain disorders

Self-repairing cancer cells: A new pathway for cancer treatment

Defective PTCHD1 gene in brain creates symptoms associated with autism and ADHD

New type of nerve cells appears to control feeding behaviors in mice

UT Southwestern researchers identify new role for protein linked to neurological disorders and cancers

UC San Diego researchers use CRISPR-Cas9 system to target RNA in living cells for first time ever

New drug could transform treatment of metastatic triple negative breast cancer

Could environmental toxins trigger amyloid plaques in the brain? An interview with Dr Paul Alan Cox

Scientists discover brain mechanisms that separate food consumption from cravings

First atomic-scale view of interaction between HIV capsid and host protein cyclophilin A

Unlocking H5N1 virus replication: an interview with Martin Blackledge

New research sheds light on circadian rhythms

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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