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Fluorescent molecules in urine can help monitor malignant melanoma

What if you could simply provide a urine sample rather than undergo a painful surgical procedure to find out if your cancer was responding to treatment? It may seem too good to be true, but researchers at Pavol Jozef Šafárik University in Košice, Slovakia, have identified fluorescent molecules in urine that may allow patients with malignant melanoma to do just that.

11 Aug 2020

NSD2 enzyme protects against cellular senescence

Researchers from Kumamoto University in Japan have used comprehensive genetic analysis to find that the enzyme NSD2, which is known to regulate the actions of many genes, also works to block cell aging.

7 Aug 2020

Study demonstrates the dual effect of acetate in immune response

The concentration of acetate increases particularly sharply at the site of an infection in the body. As reported in the journal Cell Metabolism by a team of researchers from the University of Basel and colleagues, acetate supports the function of certain immune cells and thus helps to eliminate pathogens safely and efficiently.

5 Aug 2020

Disruptions to lipid metabolism after childbirth predict future diabetes risk

Scientists have found that disruptions to the metabolism of lipids occur after childbirth in women with gestational diabetes who go on to develop type 2 diabetes.

4 Aug 2020

ALKBH5 enzyme shows promising target for cancer immunotherapy

Cancer immunotherapy -; a treatment that better enables a patient's own immune system to attack tumors -; has shown great potential against some cancers. Yet immunotherapy doesn't work against all tumor types, and many patients who initially respond later develop resistance and relapse.

4 Aug 2020

Chlamydiae need a lot of glutamine to multiply in human cells

If chlamydiae want to multiply in a human cell, the first thing they need is a lot of glutamine. Würzburg researchers have clarified how the pathogenic bacteria obtain this substance.

3 Aug 2020

Membrane protein regulates epigenetic plasticity by mediating iron endocytosis

CNRS researchers at the Institut Curie have recently shown that cancer cells use a membrane protein that has been known for several decades to internalise iron.

3 Aug 2020

Scientists identify robust set of biomarkers to help guide treatment for brain injuries

A scientific team led by the University of Arizona and the Translational Genomics Research Institute, an affiliate of City of Hope, identified a robust set of biomarkers through proteomics and metabolomic analysis that could help guide treatment for tens of millions of patients who each year sustain brain injuries, potentially preventing severe long-term disabilities.

3 Aug 2020

Study suggests new approach to make radiation therapy more effective for glioblastoma patients

Many modern cancer drugs target a specific genetic mutation that is driving a particular cancer's runaway growth and division -- such as the HER-2 protein in some breast cancers or EGFR in certain lung cancers.

30 Jul 2020

Antioxidant-rich foods may increase risk for bowel cancers, study finds

It is a fact that has long baffled doctors: Cancer in the small intestine is quite rare, whereas colorectal cancer, a neighboring though much smaller organ, is one of the leading causes of cancer death for men and women. What is it about the colon that seems to "attract" cancer?

29 Jul 2020

Low plasma vitamin D level appears to be an independent risk factor for COVID-19 infection

Vitamin D is recognized as an important co-factor in several physiological processes linked with bone and calcium metabolism, and also in diverse non-skeletal outcomes, including autoimmune diseases, cardiovascular diseases, type 2 diabetes, obesity and cognitive decline, and infections.

27 Jul 2020

Study: L-Grb2 has therapeutic efficacy in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

Research suggests a possible new approach to treating neurodegenerative diseases

Researchers at Vanderbilt University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.

21 Jul 2020

An abundance of biomolecules linked to COVID-19 status and severity

Tapping into the potential of the multi-omic method to uncover functional connections between various classes of biomolecules, researchers from notable institutions in the United States have discovered sets of co-varying molecules that shed light on coronavirus disease (COVID-19) pathophysiology and provide treatment opportunities.

20 Jul 2020

Study identifies toxicological risks of environmental pollutants in finless porpoises

A recent study just published in Environmental Science & Technology identified the toxicological risks of environmental pollutants to finless porpoises (Neophocaena asiaeorientalis).

20 Jul 2020

George Mason researcher explores if COVID-19 could be diagnosed via sweat metabolites

Emanuela Marasco, Assistant Professor, Center for Secure Information Systems, is working to determine whether COVID-19 could be diagnosed via sweat metabolites.

17 Jul 2020

Common antioxidant enzyme catalase as COVID-19 treatment

A new paper by researchers from the USA and China and published on the preprint server bioRxiv in July 2020 discusses a new drug based on the catalase enzyme, which could play a vital part in reducing the inflammation associated with progressive and severe COVID-19 disease.

17 Jul 2020

Metabolites News and Research

Fluorescent molecules in urine can help monitor malignant melanoma

NSD2 enzyme protects against cellular senescence

Study demonstrates the dual effect of acetate in immune response

Disruptions to lipid metabolism after childbirth predict future diabetes risk

ALKBH5 enzyme shows promising target for cancer immunotherapy

Chlamydiae need a lot of glutamine to multiply in human cells

Membrane protein regulates epigenetic plasticity by mediating iron endocytosis

Scientists identify robust set of biomarkers to help guide treatment for brain injuries

Study suggests new approach to make radiation therapy more effective for glioblastoma patients

Antioxidant-rich foods may increase risk for bowel cancers, study finds

Low plasma vitamin D level appears to be an independent risk factor for COVID-19 infection

Study: L-Grb2 has therapeutic efficacy in preclinical models of ovarian and uterine cancer

Research suggests a possible new approach to treating neurodegenerative diseases

An abundance of biomolecules linked to COVID-19 status and severity

Study identifies toxicological risks of environmental pollutants in finless porpoises

George Mason researcher explores if COVID-19 could be diagnosed via sweat metabolites

Common antioxidant enzyme catalase as COVID-19 treatment

Research will help improve diagnosis of disease in newborn babies from urine samples

Bed bugs alter microbial community composition of infested homes

SARS-CoV-2 a dagger to the aging heart

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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