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MD Anderson and Eisbach Bio collaborate to develop precision oncology drugs

The University of Texas MD Anderson Cancer Center and Eisbach Bio GmbH today announced a strategic research collaboration to jointly discover and develop precision oncology drugs that target synthetic lethal engines key to tumor genome evolution.

18 Jan 2022

Subcutaneous nanotherapy can make immunomodulation more effective in people with type 1 diabetes

Individuals living with type 1 diabetes must carefully follow prescribed insulin regimens every day, receiving injections of the hormone via syringe, insulin pump or some other device. And without viable long-term treatments, this course of treatment is a lifelong sentence.

18 Jan 2022

Study: Nearly 30% of people with blinding retinal disease can safely stop eye injection therapy

In a preliminary study of 106 people with "wet" age-related macular degeneration, Johns Hopkins Medicine researchers report that as many as a third of those with the blinding retinal disease may someday be able to safely stop eye injection therapy without further vision loss.

18 Jan 2022

ACP guidelines: Uncomplicated diverticulitis can be treated in an outpatient setting without antibiotics

According to two new clinical guidelines from the American College of Physicians, uncomplicated diverticulitis can be treated in an outpatient setting without antibiotics.

18 Jan 2022

Antibody responses to COVID-19 mRNA vaccines in a cohort of healthcare workers

Researchers have been investigating the vaccine response of healthcare workers from specific vaccines to different variants.

18 Jan 2022

An alternative mouse model of SARS-CoV-2 infection

Recently, a study has shown the possibility of repurposing hACE2 transgenic mice, primarily raised to study SARS-CoV, to support SARS-CoV-2 infection and pathogenesis.

17 Jan 2022

DPP4 protein: The connection between severe COVID-19 and diabetes

Researchers explore the relationship between DPP4 and diabetes targets in the management of COVID-19.

17 Jan 2022

SARS-CoV-2 interacts with heparan sulfate to activate the alternative pathway

A new study discusses the activation of the complement system to determine its role in COVID-19-related deaths.

17 Jan 2022

New method may help make immunomodulation more effective in individuals with Type 1 diabetes

Individuals living with Type 1 diabetes must carefully follow prescribed insulin regimens every day, receiving injections of the hormone via syringe, insulin pump or some other device. And without viable long-term treatments, this course of treatment is a lifelong sentence.

17 Jan 2022

Researchers investigate the role of a key component of the circadian clock in heart disease

Disrupting circadian rhythms, which change naturally on a 24-hour cycle, has been implicated in heart disease, but it is unclear how it leads to the condition.

17 Jan 2022

Efficacy and safety of mRNA-based SARS-CoV-2 vaccination in immuno-compromised subjects

A team of researchers assessed the immune response after administering a SARS-COV-2 vaccine in immuno-compromised subjects who are potentially at an increased risk to experience severe COVID-19 and inadequate response to SARS-CoV2 vaccination.

17 Jan 2022

Study evaluates acute and long-term adverse events following immunization with COVID-19 Moderna vaccine

In a new study, a team of researchers conducted a case-control study at a mass vaccination center in Japan to evaluate acute and long-term adverse events following immunization (AEFI) with coronavirus disease 2019 (COVID-19) Moderna vaccine.

17 Jan 2022

Study identifies cellular receptors for alphaviruses shared across mosquitoes, humans, and animals

A new study led by researchers at Harvard Medical School has identified a set of cellular receptors for at least three related alphaviruses shared across mosquitoes, humans, and animals that host the virus.

17 Jan 2022

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health report successfully removing the nucleus out of a type of ubiquitous cell, known as enucleation, then using the genetically engineered cell as a unique cargo-carrier to deliver therapeutics precisely to diseased tissues.

17 Jan 2022

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

A new study, published in the journal Cell Chemical Biology, has reported the discovery of acriflavine (ACF), an effective inhibitor of SARS-CoV-2. This drug is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine).

16 Jan 2022

Cannabidiol may improve innate immune response against SARS-CoV-2

A recent study shows evidence that cannabidiol, an important active ingredient in the Cannabis sativa plant, can augment the antiviral innate immune response and prophylactically prime the innate antiviral response of cells – enabling in turn improved response against viruses such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Jan 2022

UMass Amherst professor receives $2 million NIH MIRA grant for trailblazing research

Jianhan Chen, a University of Massachusetts Amherst chemistry and biochemistry and molecular biology professor, has received a five-year, $2 million National Institutes of Health (NIH) grant to support research in his computational biophysics lab aimed at better understanding the role of intrinsically disordered proteins (IDPs) in biology and human disease.

16 Jan 2022

WHO's recommendation provides two new options for treating COVID-19

WHO has recommended two new drugs for COVID-19, providing yet more options for treating the disease. The extent to which these medicines will save lives depends on how widely available and affordable they will be.

16 Jan 2022

Rapid antigen test for SARS-CoV-2 proves to be highly accurate for pediatric populations

In a large prospective study of just over 1,000 patients ages 17 and younger who were seen at the Baltimore Convention Center Field Hospital (BCCFH) testing site during a seven-month period last year, researchers from Johns Hopkins Medicine and collaborating institutions report that a rapid antigen test for SARS-CoV-2 — the virus that causes COVID-19 — proved highly accurate when compared to the established standard virus detection method: the polymerase chain reaction (PCR).

16 Jan 2022

Study shows possible reverse zoonoses of SARS-CoV-2 from humans to animals

A new study describes an instance of natural infection of SARS-CoV-2 in a puma during the first wave and three lions during the third wave in a private zoo in South Africa in at least three transmission events from their handlers.

14 Jan 2022

Drugs News and Research

MD Anderson and Eisbach Bio collaborate to develop precision oncology drugs

Subcutaneous nanotherapy can make immunomodulation more effective in people with type 1 diabetes

Study: Nearly 30% of people with blinding retinal disease can safely stop eye injection therapy

ACP guidelines: Uncomplicated diverticulitis can be treated in an outpatient setting without antibiotics

Antibody responses to COVID-19 mRNA vaccines in a cohort of healthcare workers

An alternative mouse model of SARS-CoV-2 infection

DPP4 protein: The connection between severe COVID-19 and diabetes

SARS-CoV-2 interacts with heparan sulfate to activate the alternative pathway

New method may help make immunomodulation more effective in individuals with Type 1 diabetes

Researchers investigate the role of a key component of the circadian clock in heart disease

Efficacy and safety of mRNA-based SARS-CoV-2 vaccination in immuno-compromised subjects

Study evaluates acute and long-term adverse events following immunization with COVID-19 Moderna vaccine

Study identifies cellular receptors for alphaviruses shared across mosquitoes, humans, and animals

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

Cannabidiol may improve innate immune response against SARS-CoV-2

UMass Amherst professor receives $2 million NIH MIRA grant for trailblazing research

WHO's recommendation provides two new options for treating COVID-19

Rapid antigen test for SARS-CoV-2 proves to be highly accurate for pediatric populations

Study shows possible reverse zoonoses of SARS-CoV-2 from humans to animals

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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