Clinical Trial News and Research

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Clinical study explores effect of iron supplements in reducing hospitalisation in heart failure patients

A clinical study - known as IRONMAN - will determine if iron supplement injections could ease the disabling symptoms of heart failure. The trial was officially launched today at the British Cardiovascular Society Conference in Manchester.

6 Jun 2016

Mastectomy followed by standard therapy improves survival in stage IV breast cancer patients

Surgery to remove the primary tumor in women diagnosed with stage IV breast cancer, followed by the standard combination of therapies, adds months to the patients' lives, compared with standard therapy alone, an international clinical trial led by a University of Pittsburgh Cancer Institute professor revealed.

4 Jun 2016

Clinical study finds two topical skin creams as effective noninvasive treatments for low-risk superficial BCC

Basal cell carcinoma is one of the most common cancers and its incidence is increasing worldwide, putting a significant burden on health services. Topical treatments are available for superficial basal cell carcinoma (BCC) but there has a lack of long-term follow-up data to guide treatment decisions.

3 Jun 2016

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

Neuroblastoma tumors shrank, some dramatically, in 80 percent of newly diagnosed, young, high-risk patients enrolled in a Phase II clinical trial that included an experimental monoclonal antibody. The immunotherapy agent was produced on the St. Jude Children's Research Hospital campus where the study is still underway.

3 Jun 2016

Analysing blood metabolites may help monitor effects of novel drugs

Testing for metabolic changes in the blood could indicate whether a cancer drug is working as designed, a new study reports.

3 Jun 2016

Retroviral replicating vector can extend lives of brain cancer patients

Doctors at UCLA, Cleveland Clinic, University of California San Diego School of Medicine and additional institutions have achieved a milestone in the development of a treatment for people with recurrent glioblastoma, the most common and aggressive form of brain cancer, by successfully demonstrating a modified virus that can extend the lives of patients with the disease.

2 Jun 2016

Scientists reveal how ER+ breast cancer uses cholesterol-based molecule to evade anti-hormone treatments

New research funded by Breast Cancer Now has identified how the most common breast cancers could be using a cholesterol-based molecule to evade standard anti-hormone treatments, causing patients’ disease to return.

2 Jun 2016

FDA approves blood-based cobas EGFR Mutation Test v2 for NSCLC patients

The U.S. Food and Drug Administration today approved the cobas EGFR Mutation Test v2, a blood-based companion diagnostic for the cancer drug Tarceva (erlotinib). This is the first FDA-approved, blood-based genetic test that can detect epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer patients.

2 Jun 2016

Clinical trial to evaluate ability of MRI to improve prostate cancer diagnosis

The Movember Foundation, the Ontario Institute for Cancer Research and Prostate Cancer Canada today announced $3 million in funding for a new Phase III clinical trial to evaluate if magnetic resonance imaging (MRI) can replace the current standard of care to diagnose prostate cancer.

2 Jun 2016

$CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory$

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

A two-year, multi-center clinical study with 167 patients with class III-IV refractory angina randomized to low and high dose CD34+ cells or placebo has revealed that patients who received either a high or low dose of CD34 -- a member of a family of proteins that have an impact on vascular-associated tissue -- cells had a significant reduction in angina frequency over patients who received placebo.

2 Jun 2016

Clinical trial to test safety, efficacy of Roswell Park-developed SurVaxM in multiple myeloma patients

An immune-based therapy developed at Roswell Park Cancer Institute is moving forward with its third clinical trial. The early-stage clinical trial will assess whether SurVaxM — a cancer vaccine developed at Roswell Park — is a safe and effective treatment option for patients with multiple myeloma, a rare type of blood cancer.

1 Jun 2016

Ocaliva drug gets FDA approval for primary biliary cholangitis treatment

On Friday, May 27, the U.S. Food and Drug Administration granted accelerated approval for Ocaliva (obeticholic acid) for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA, or as a single therapy in adults unable to tolerate UDCA.

1 Jun 2016

Vital compound in common anti-inflammatory drugs can combat cancer, inflammation

Scientists from the Gladstone Institutes have identified a new pathway by which salicylic acid--a key compound in the nonsteroidal anti-inflammatory drugs aspirin and diflunisal--stops inflammation and cancer.

1 Jun 2016

Overcoming barriers in autism research: an interview with Gahan Pandina

There are currently no medications which address the core symptoms of ASD, and a significant barrier to their development is that researchers have historically lacked effective methods for measuring clinical outcomes.

30 May 2016

Trial results underestimate anticoagulant bleeding risk

A study in The BMJ demonstrates that estimates of major bleeding risk in patients taking anticoagulants in clinical trials are unlikely to reflect the reality of clinical practice.

28 May 2016

UTHealth's Mobile Stroke Unit fights stroke through research, technology and patient care

About 800,000 strokes occur in America each year; that's about one every 40 seconds. Houston resident Joe Carrabba experienced one of them.

28 May 2016

Zinbryta gets FDA approval for treating adults with relapsing forms of MS

The U.S. Food and Drug Administration today approved Zinbryta (daclizumab) for the treatment of adults with relapsing forms of multiple sclerosis (MS). Zinbryta is a long-acting injection that is self- administered by the patient monthly.

28 May 2016

Study identifies potential new treatment for subset of gastric cancer patients

Testing cancers for 'addiction' to a gene that boosts cell growth can pick out patients who may respond to a targeted drug under development, a major new study reports.

28 May 2016

First buprenorphine implant for opioid dependence treatment gets FDA approval

The U.S. Food and Drug Administration today approved Probuphine, the first buprenorphine implant for the maintenance treatment of opioid dependence. Probuphine is designed to provide a constant, low-level dose of buprenorphine for six months in patients who are already stable on low-to-moderate doses of other forms of buprenorphine, as part of a complete treatment program.

27 May 2016

Fasting-mimicking diet may help decrease multiple sclerosis symptoms

Evidence is mounting that a diet mimicking the effects of fasting has health benefits beyond weight loss, with a new USC-led study indicating that it may reduce symptoms of multiple sclerosis.

27 May 2016

Clinical Trial News and Research

Clinical study explores effect of iron supplements in reducing hospitalisation in heart failure patients

Mastectomy followed by standard therapy improves survival in stage IV breast cancer patients

Clinical study finds two topical skin creams as effective noninvasive treatments for low-risk superficial BCC

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

Analysing blood metabolites may help monitor effects of novel drugs

Retroviral replicating vector can extend lives of brain cancer patients

Scientists reveal how ER+ breast cancer uses cholesterol-based molecule to evade anti-hormone treatments

FDA approves blood-based cobas EGFR Mutation Test v2 for NSCLC patients

Clinical trial to evaluate ability of MRI to improve prostate cancer diagnosis

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

Clinical trial to test safety, efficacy of Roswell Park-developed SurVaxM in multiple myeloma patients

Ocaliva drug gets FDA approval for primary biliary cholangitis treatment

Vital compound in common anti-inflammatory drugs can combat cancer, inflammation

Overcoming barriers in autism research: an interview with Gahan Pandina

Trial results underestimate anticoagulant bleeding risk

UTHealth's Mobile Stroke Unit fights stroke through research, technology and patient care

Zinbryta gets FDA approval for treating adults with relapsing forms of MS

Study identifies potential new treatment for subset of gastric cancer patients

First buprenorphine implant for opioid dependence treatment gets FDA approval

Fasting-mimicking diet may help decrease multiple sclerosis symptoms

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