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Immunotherapy response in patients with advanced melanoma depends on prior treatments

Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.

10 Apr 2023

Study examines whether alcohol-associated burn injuries impair cognitive function

The relationship between alcohol use and burn injuries is a negative one in multiple ways. Not only are about 50% of adults who sustain burn injuries intoxicated at the time of injury, suggesting that alcohol use may have contributed to the incident, but alcohol use among burn-injured patients is associated with more severe complications, delayed recovery, and increased morbidity and mortality.

10 Apr 2023

Beclin-1 plays a key role in endometrial reprogramming for successful establishment of pregnancy

Throughout a woman's reproductive life, the endometrium, the mucous membrane lining the uterus, goes through cyclical remodeling. It thickens during the menstrual cycle in preparation for embryo implantation, and it is shed during menstruation when there is no fertilization.

10 Apr 2023

Novel amino acid compound treats nonalcoholic fatty liver disease in non-human primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates - bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

10 Apr 2023

The distribution and prevalence of SARS-CoV-2 in the Huanan seafood market

Researchers surveyed SARS-CoV-2 at the Huanan seafood market (HSM).

10 Apr 2023

For uninsured people with cancer, securing care can be like spinning a roulette wheel

Eighteen months after April Adcox learned she had skin cancer, she finally returned to Charleston's Medical University of South Carolina last May to seek treatment.

10 Apr 2023

Study highlights the potential long-term neurological effects post-COVID-19

Researchers studied the presence of the SARS-CoV-2 spike protein in the skull-meninges-brain (SMB) axis.

10 Apr 2023

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Researchers highlight how dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment.

10 Apr 2023

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

Study suggests potential therapeutic targets for COVID-19-related neurological pathologies

In a recent study published in the journal Molecular & Cellular Proteomics, researchers analyzed the proteins in cerebrospinal fluid (CSF) samples obtained from African green monkeys and rhesus macaques infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 to understand the neurological manifestations of coronavirus disease 2019 (COVID-19).

9 Apr 2023

Study reveals SARS-CoV-2 on hands and frequently-touched surfaces as key predictors of household transmission

A study investigating risk factors and vectors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission reveals that the presence of the virus on the hands of primary and secondary cases and on frequently-touched surfaces is associated with transmission risk. The study is published in the journal THE LANCET Microbe.

9 Apr 2023

New finding in roundworms upends classical thinking about animal cell differentiation

Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.

7 Apr 2023

Regulatory T cell populations descend from two different origins, finds study

A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children's Hospital of Philadelphia (CHOP).

7 Apr 2023

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Inflammatory bowel disease, or IBD, describes Crohn's disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder - a condition in which the body's immune system attacks healthy tissues.

7 Apr 2023

Newly discovered antibody appears to block infection by all dominant variants of SARS-CoV-2 virus

A team led by researchers at Weill Cornell Medicine, the University of Wisconsin-Madison; Scripps Research and the University of Chicago has identified an antibody that appears to block infection by all dominant variants of the virus that causes COVID-19, including Omicron, the most recent.

7 Apr 2023

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Gene editing is one of the latest breakthroughs in biology. The widely known CRISPR-Cas gene editing system provided prokaryotes (organisms that lack cell nuclei) an immunity against foreign DNA. Since the discovery of the CRISPR gene editing technology, scientists are revealing the evolution of the CRISPR-Cas proteins from their precursors.

7 Apr 2023

Leveraging cell self-destruction to treat glioblastoma tumors

Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better therapies.

7 Apr 2023

B Cell News and Research

Immunotherapy response in patients with advanced melanoma depends on prior treatments

Study examines whether alcohol-associated burn injuries impair cognitive function

Beclin-1 plays a key role in endometrial reprogramming for successful establishment of pregnancy

Novel amino acid compound treats nonalcoholic fatty liver disease in non-human primates

The distribution and prevalence of SARS-CoV-2 in the Huanan seafood market

For uninsured people with cancer, securing care can be like spinning a roulette wheel

Study highlights the potential long-term neurological effects post-COVID-19

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Study suggests potential therapeutic targets for COVID-19-related neurological pathologies

Study reveals SARS-CoV-2 on hands and frequently-touched surfaces as key predictors of household transmission

New finding in roundworms upends classical thinking about animal cell differentiation

Regulatory T cell populations descend from two different origins, finds study

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Newly discovered antibody appears to block infection by all dominant variants of SARS-CoV-2 virus

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Leveraging cell self-destruction to treat glioblastoma tumors

Is preserved vegetable consumption associated with mortality?

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Study explores the association between gut microbiome dysbiosis and uveitis

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