Clinical Trial News and Research

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Combining sonoporation with chemotherapy drug may help improve pancreatic cancer treatment

Researchers at Haukeland University Hospital in Bergen, Norway have combined a laboratory ultrasound technique called "sonoporation" with the commercially-available chemotherapy compound Gemcitabine to increase the porosity of pancreatic cells with microbubbles and to help get the drug into cancer cells where it is needed.

26 May 2016

Combining vitamin A with chemotherapy may offer promise for pancreatic cancer treatment

Around 8,800 people in the UK are diagnosed with pancreatic cancer each year. It is known as the UK's deadliest cancer, with a survival rate of just 3 per cent. Chemotherapy and radiotherapy alone are relatively unsuccessful in treating the disease, and while surgery to remove the tumour offers the best chance of survival, most patients are diagnosed when the cancer has already spread to other organs.

25 May 2016

Sylvester researchers test new KTE-C19 therapy for patients with aggressive non-Hodgkin's lymphoma

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are testing a novel cellular immunotherapy approach to treating patients with diffuse large B-cell lymphoma who have failed standard therapy.

25 May 2016

First clinical trial to study use of Chinese Herbal Medicines in treating RUTIs

Researchers at the University of Southampton are to study the use of Chinese Herbal Medicines in treating recurrent urinary tract infections (RUTIs), in the first clinical trial of its kind in the UK.

25 May 2016

Obese teenagers may have lower levels of spexin harmone

Obese teenagers already show signs of hormonal differences from normal-weight peers that may make them prone to weight gain, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

25 May 2016

Clinical trials of anti-cancer agent PAC-1 continue to progress with anonymous funding

Clinical trials of the anti-cancer agent PAC-1 are continuing to expand, thanks to a $7 million angel investment from an anonymous contributor who originally invested $4 million to help get the compound this far in the drug-approval pipeline.

25 May 2016

Diet-based therapy may improve quality of life in IBS patients

A change in diet can improve the lives of those diagnosed with a common, but hard-to-treat gut disorder.

25 May 2016

Telephone-based intervention helps reduce menopause-related insomnia, hot flashes

Chatting on the phone with a "sleep coach" and keeping a nightly sleep diary significantly improve sleep quality and reduce insomnia in women through all stages of menopause, according to a new study published today in JAMA Internal Medicine.

24 May 2016

Physical exercise may be as effective as drugs for treating prostate cancer patients

At age 70, Alfred Roberts plays hockey twice a week. Nothing special, right? Except that for three years he has had advanced prostate cancer, which has spread to his bones. "I've always been active. Hockey keeps me in shape and keeps my mind off things. I've got friends that have played until age 80, and my goal is to beat them!" said the veteran stick handler.

24 May 2016

Ongoing treatment with nivolumab shows benefit in advanced kidney cancer patients

Only 12% of kidney cancer patients with advanced disease survive five years after their initial treatment. In a Roswell Park Cancer Institute-led study, scientists report that some patients with advanced kidney cancer who continued to receive a novel immunotherapy drug after their disease progressed saw clinical benefit.

24 May 2016

Clinical study examines efficacy of new interactive software game to treat pediatric food allergies

Elizabeth McQuaid, Ph.D., a staff psychologist from the Bradley Hasbro Children's Research Center, is leading the Phase II trial of an interactive software game developed to help children with food allergies better manage allergy symptoms, social situations and proper food avoidance.

23 May 2016

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

The investigational anticancer therapeutic abemaciclib, which targets CDK4 and CDK6, showed durable clinical activity when given as continuous single-agent therapy to patients with a variety of cancer types, including breast cancer, non-small cell lung cancer (NSCLC), glioblastoma, and melanoma, according to results from a phase I clinical trial.

23 May 2016

Older, frail hypertensive adults could benefit from intensive lowering of blood pressure

Adults with hypertension who are age 75 years and older, including those who are frail and with poor overall health, could benefit from lowering their blood pressure below current medical guidelines.

20 May 2016

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Using gene editing technology, researchers at the Lewis Katz School of Medicine at Temple University have, for the first time, successfully excised a segment of HIV-1 DNA - the virus responsible for AIDS - from the genomes of living animals.

20 May 2016

Combining 2-DG with fenofibrate could provide non-toxic treatments for many cancers

A team of researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine recently discovered a novel, non-toxic approach to treating a wide variety of cancers.

19 May 2016

New skin test for TB infection proves safe, effective in clinical trials

A new skin test for tuberculosis infection has proven safe, easy to administer and accurate in two Phase III clinical trials, according to research presented at the ATS 2016 International Conference.

19 May 2016

USP14 enzyme could be promising biomarker for detecting risk of endometrial cancer recurrences

Endometrial cancer is the most common gynecologic cancer in the U.S. Most cases are diagnosed at early stage and have good prognosis. Unfortunately, some patients with early stage and low grade endometrial cancer experience recurrence - and the reasons are not entirely clear.

19 May 2016

Higher adolescent intake of saturated fat linked to higher dense breast volume in early adulthood

Consuming high amounts of saturated fat or low amounts of mono- and polyunsaturated fats as an adolescent was associated with higher breast density in young adulthood. Breast density is a risk factor for breast cancer.

19 May 2016

Tecentriq drug gets FDA approval to treat urothelial carcinoma

The U.S. Food and Drug Administration today approved Tecentriq (atezolizumab) to treat the most common type of bladder cancer, called urothelial carcinoma. This is the first product in its class (PD-1/PD-L1 inhibitors) approved to treat this type of cancer.

19 May 2016

Pediatric feasibility study results set stage for clinical trial of world’s first bioabsorbable heart valve enabling Endogenous Tissue Restoration

One-year follow-up results from a pediatric feasibility study of Xeltis bioabsorbable cardiovascular pulmonary graft have been presented as late-breaker at the 96th American Association for Thoracic Surgery annual meeting today.

19 May 2016

Clinical Trial News and Research

Combining sonoporation with chemotherapy drug may help improve pancreatic cancer treatment

Combining vitamin A with chemotherapy may offer promise for pancreatic cancer treatment

Sylvester researchers test new KTE-C19 therapy for patients with aggressive non-Hodgkin's lymphoma

First clinical trial to study use of Chinese Herbal Medicines in treating RUTIs

Obese teenagers may have lower levels of spexin harmone

Clinical trials of anti-cancer agent PAC-1 continue to progress with anonymous funding

Diet-based therapy may improve quality of life in IBS patients

Telephone-based intervention helps reduce menopause-related insomnia, hot flashes

Physical exercise may be as effective as drugs for treating prostate cancer patients

Ongoing treatment with nivolumab shows benefit in advanced kidney cancer patients

Clinical study examines efficacy of new interactive software game to treat pediatric food allergies

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

Older, frail hypertensive adults could benefit from intensive lowering of blood pressure

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Combining 2-DG with fenofibrate could provide non-toxic treatments for many cancers

New skin test for TB infection proves safe, effective in clinical trials

USP14 enzyme could be promising biomarker for detecting risk of endometrial cancer recurrences

Higher adolescent intake of saturated fat linked to higher dense breast volume in early adulthood

Tecentriq drug gets FDA approval to treat urothelial carcinoma

Pediatric feasibility study results set stage for clinical trial of world’s first bioabsorbable heart valve enabling Endogenous Tissue Restoration

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