Clinical Trial News and Research

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Real-world CML management in line with ELN guidelines

The first-line treatment and monitoring of patients with chronic phase-chronic myeloid leukaemia is in accordance with the European LeukaemiaNet recommendations, finds a real-world clinical practice study.

18 May 2016

CML treatment-free remission criteria outlined

Treatment-free remission may be feasible in many patients with chronic myeloid leukaemia, say researchers who set out clinical and logistical requirements for discontinuing tyrosine kinase inhibitor therapy.

18 May 2016

Study demonstrates effectiveness of NeuroStar TMS Therapy System in women with postpartum depression

An unfortunate fact facing mothers in the U.S. is that postpartum depression is the most common complication of childbirth. Approximately 10 to 15 percent of women who give birth each year – or roughly 600,000 women – experience postpartum depression symptoms.

18 May 2016

First-ever clinical trial of bioabsorbable cardiovascular device in children shows promise

Current cardiovascular valve or blood vessel implants are generally associated with a number of complications, have limited efficacy over time, and may necessitate repeated interventions over a patient's lifetime, especially when implanted in a young child.

18 May 2016

Consuming sesame-based ingredients may reduce oxidative stress

The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress, improving human health, according to a systematic review published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

18 May 2016

Research on immune system sets stage for novel approach to cancer immunotherapy

Basic research into the dual nature of certain immune system cells has set the stage for a new approach to cancer immunotherapy that avoids some of the shortcomings associated with other methods, scientists at Dana-Farber Cancer Institute report in a new study in the Proceedings of the National Academy of Sciences.

17 May 2016

RDAVR system improves survival of patients with severe aortic stenosis

When replacing a defective aortic valve with a new one, restoring function is the first priority. However, variables such as durability, length of surgery, duration of heart stoppage, size of the surgical incision, postoperative pain, and complications are other important considerations.

17 May 2016

Phase 2 results of AbbVie’s venetoclax in patients with R/R CLL with 17p deletion published in The Lancet Oncology

AbbVie, a global biopharmaceutical company, today announced The Lancet Oncology published results from the Phase 2, single arm, open label trial studying venetoclax in patients with relapsed/refractory (R/R) chronic lymphocytic leukaemia (CLL) with 17p deletion.

17 May 2016

Arkin Holdings and Primera Capital lead investment of $13M in BioSight

BioSight, Ltd, an Israeli pharmaceutical development company focused on the development of innovative chemotherapy pro-drugs with reduced toxicity, announced today the closing of an investment of $13M led by the Mori Arkin's pharmaceutical investment firm, Arkin Holdings, and the US based venture firm Primera Capital. Proceeds of the financing will be used to fund a multi-center phase IIb clinical trial with the company's lead product, Astarabine™, for the treatment of AML.

16 May 2016

Pluristem completes enrollment in Phase II intermittent claudication trial

Pluristem Therapeutics Inc., a leading developer of placenta-based cell therapy products, today announced it has completed the planned enrollment of 150 patients in a global Phase II trial of its PLacental eXpanded (PLX)-PAD cells for the treatment of intermittent claudication (IC), a peripheral artery disease (PAD). The double blind, randomized, placebo controlled trial enrolled 50 patients since October 2015 in the U.S., Germany, Israel, and South Korea.

16 May 2016

Boehringer Ingelheim presents new data on OFEV® (nintedanib) in idiopathic pulmonary fibrosis (IPF)

New analyses presented at the American Thoracic Society’s 2016 annual conference (ATS 2016) further add to the efficacy and safety profile of OFEV® (nintedanib) in idiopathic pulmonary fibrosis (IPF).

16 May 2016

Cedars-Sinai researchers explore whether healthy lifestyle choices can slow or prevent Alzheimer's disease

Cedars-Sinai neuroscience researchers are studying whether extensive changes in lifestyle among patients with mild cognitive impairment can slow the progression of Alzheimer's disease.

13 May 2016

New research solves mystery of why cetuximab drug proved futile for many colorectal cancer patients

Cancer researchers have identified a marker that shows up in a blood test that determines which patients with colorectal cancer that has spread would benefit from receiving the drug cetuximab.

13 May 2016

Clinical study shows sitagliptin drug not effective in treating NAFLD

A diabetes medication described in some studies as an effective treatment for nonalcoholic fatty liver disease (NAFLD) works no better than a placebo, report researchers at University of California San Diego School of Medicine, after conducting the first randomized, double-blind, controlled clinical trial of sitagliptin, an oral antihyperglycemic marketed by Merck & Co. under the name Januvia.

13 May 2016

Kent researchers perform first clinical trials of bionic legs for patients

Expert clinicians and engineers at the University of Kent are carrying out the first clinical trials of robotic legs for patients

13 May 2016

Same-day initiation of antiretroviral therapy for HIV patients may lead to better health outcomes

A clinical trial of same-day initiation of antiretroviral therapy (ART) for HIV patients in South Africa led to a higher proportion of people starting treatment and to better health outcomes, according to a new study led by a Boston University School of Public Health researcher.

12 May 2016

New IsoPSA test identifies molecular structural changes in protein biomarkers to detect prostate cancer

A promising new test is detecting prostate cancer more precisely than current tests, by identifying molecular changes in the prostate specific antigen (PSA) protein, according to Cleveland Clinic research presented today at the American Urological Association annual meeting.

12 May 2016

Combination of two compounds found in red grapes, oranges could treat diseases

A combination of two compounds found in red grapes and oranges could be used to improve the health of people with diabetes, and reduce cases of obesity and heart disease.

12 May 2016

Could oral supplements affect teenage behavior? An interview with Prof. Stein and Dr Tammam

We wanted to see whether supplementing the diet of disadvantaged adolescents with the omega 3 polyunsaturated acids, EPA & DHA, vitamins and minerals over a school term might improve their antisocial behaviour, which usually gets worse during a term.

12 May 2016

Computerized decision support tool can assist physicians in prescribing stroke prevention therapy

Physician-researchers in the College of Medicine at the University of Cincinnati have developed a computerized decision support tool that uses a combination of patient information and characteristics to assist physicians and patients with decisions about blood thinning treatment to prevent strokes in individuals with atrial fibrillation.

12 May 2016

Clinical Trial News and Research

Real-world CML management in line with ELN guidelines

CML treatment-free remission criteria outlined

Study demonstrates effectiveness of NeuroStar TMS Therapy System in women with postpartum depression

First-ever clinical trial of bioabsorbable cardiovascular device in children shows promise

Consuming sesame-based ingredients may reduce oxidative stress

Research on immune system sets stage for novel approach to cancer immunotherapy

RDAVR system improves survival of patients with severe aortic stenosis

Phase 2 results of AbbVie’s venetoclax in patients with R/R CLL with 17p deletion published in The Lancet Oncology

Arkin Holdings and Primera Capital lead investment of $13M in BioSight

Pluristem completes enrollment in Phase II intermittent claudication trial

Boehringer Ingelheim presents new data on OFEV® (nintedanib) in idiopathic pulmonary fibrosis (IPF)

Cedars-Sinai researchers explore whether healthy lifestyle choices can slow or prevent Alzheimer's disease

New research solves mystery of why cetuximab drug proved futile for many colorectal cancer patients

Clinical study shows sitagliptin drug not effective in treating NAFLD

Kent researchers perform first clinical trials of bionic legs for patients

Same-day initiation of antiretroviral therapy for HIV patients may lead to better health outcomes

New IsoPSA test identifies molecular structural changes in protein biomarkers to detect prostate cancer

Combination of two compounds found in red grapes, oranges could treat diseases

Could oral supplements affect teenage behavior? An interview with Prof. Stein and Dr Tammam

Computerized decision support tool can assist physicians in prescribing stroke prevention therapy

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