Immune System News and Research

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Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair achieved significant tumor regression in mouse models of small cell lung cancer, suggesting a promising new approach for treating patients with this aggressive cancer.

18 Feb 2019

Smoking may blight immune response against melanoma and reduce survival

Melanoma patients with a history of smoking cigarettes are 40 per cent less likely to survive their skin cancer than people who have never smoked, according to a new report funded by Cancer Research UK.

18 Feb 2019

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Columbia researchers have learned why some glioblastomas--the most common type of brain cancer--respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments.

17 Feb 2019

New technique using patients' own modified cells could help treat Crohn's disease

A new technique using patients' own modified cells to treat Crohn's disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.

15 Feb 2019

Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft

The conformance of genetic characteristics is essential for the long-term function after kidney transplantation. This is the central result of a recent study in the top journal “The Lancet” with more than 500 patients after kidney transplantation, conducted by a global consortium led by Rainer Oberbauer and his colleagues Roman Reindl-Schwaighofer and Andreas Heinzel from the Division of Nephrology and Dialysis at MedUni Vienna.

15 Feb 2019

Common herbicide found to increase the risk of Non-Hodgkin Lymphoma

A new study has shown that the herbicide glyphosphate, could increase the risk of Non-Hodgkin Lymphoma by 41 percent among those who are exposed.

15 Feb 2019

Castration-resistant metastatic prostate cancer responds to combination of immune checkpoint inhibitors

Some patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at The University of Texas MD Anderson Cancer Center presented today at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San Francisco.

15 Feb 2019

Immune checkpoint molecule protects against future development of cancer

A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered by itself.

15 Feb 2019

Discovery of weakness in a rare cancer could be exploited with drugs

Cancer cells are, in some respects, impressive: They can grow relentlessly, sidestep the aging process by becoming immortal, and evade the immune system's persistent attacks. But in the process of acquiring such superpowers, the cells must occasionally relinquish other, more mundane skills--including the ability to produce certain nutrients.

15 Feb 2019

Moffitt researchers shed light on how CAR T cells function mechanistically

The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient's own immune system to target cancer cells.

15 Feb 2019

Researchers study animal venoms to identify new medicines for treating diseases

Animal venoms are the subject of study at research center based at the Butantan Institute in São Paulo. But in this case, the idea is not to find antidotes, but rather to use the properties of the venoms themselves to identify molecular targets of diseases and, armed with that knowledge, develop new compounds that can be used as medicines.

15 Feb 2019

Human cells can change their original function to battle against diabetes

For the first time, researchers have shown that ordinary human cells can change their original function. This may give new hope for diabetes patients.

14 Feb 2019

Inflammation in middle age may indicate increased risk of dementia in later life

New research indicates that people suffering chronic inflammation during middle age show a greater decline in cognitive function as they get older.

14 Feb 2019

New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis

A new reversible, drug-free antiplatelet therapy could reduce the risk of blood clots and potentially prevent cancer metastasis, according to a study published today in Science Translational Medicine.

14 Feb 2019

Study shows how neuroactive steroids inhibit activity of pro-inflammatory proteins

For the first time, scientists discovered how neuroactive steroids naturally found in the brain and bloodstream inhibit the activity of a specific kind of protein called Toll-like receptors, which have been known to play a role in inflammation in many organs, including the brain.

14 Feb 2019

Researchers comprehensively sequence the human immune system

For the first time ever, researchers are comprehensively sequencing the human immune system, which is billions of times larger than the human genome. In a new study published in Nature from the Human Vaccines Project, scientists have sequenced a key part of this vast and mysterious system -- the genes encoding the circulating B cell receptor repertoire.

14 Feb 2019

Discovery of a 'master switch' within the immune system

Researchers Professor Graham Lord, from The University of Manchester and colleagues have found that a specific part of the immune system could have the tools that may help in the therapy of some major diseases such as diabetes, cancer, multiple sclerosis, Crohn’s disease and other autoimmune diseases.

14 Feb 2019

Sleep could be the best medicine to fight off an infection

Sleep has been underrated as the best medicine to fight off disease say researchers working on a new study. The study titled, “Gαs-Coupled Receptor Signaling and Sleep Regulate Integrin Activation of Human Antigen-Specific T Cells,” was published this week in the Journal of Experimental Medicine.

14 Feb 2019

Breast pumps could be transmitting asthma-causing bacteria in babies, finds study

Mothers across the world use breast pumps to pump put the milk that is fed to their babies. A new study has revealed that these pumps may not be safe and may be contaminated with bacteria that can cause asthma in the babies later in life. The results of this study were published in the latest issue of the journal Cell Host & Microbe.

13 Feb 2019

Western diet may increase the risk of ‘deadly sepsis’, warn experts

A new study suggests that the Western diet may increase the risk of severe sepsis and mortality from the infection.

13 Feb 2019

Immune System News and Research

Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models

Smoking may blight immune response against melanoma and reduce survival

Columbia researchers unravel why some glioblastomas respond to immunotherapy

New technique using patients' own modified cells could help treat Crohn's disease

Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft

Common herbicide found to increase the risk of Non-Hodgkin Lymphoma

Castration-resistant metastatic prostate cancer responds to combination of immune checkpoint inhibitors

Immune checkpoint molecule protects against future development of cancer

Discovery of weakness in a rare cancer could be exploited with drugs

Moffitt researchers shed light on how CAR T cells function mechanistically

Researchers study animal venoms to identify new medicines for treating diseases

Human cells can change their original function to battle against diabetes

Inflammation in middle age may indicate increased risk of dementia in later life

New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis

Study shows how neuroactive steroids inhibit activity of pro-inflammatory proteins

Researchers comprehensively sequence the human immune system

Discovery of a 'master switch' within the immune system

Sleep could be the best medicine to fight off an infection

Breast pumps could be transmitting asthma-causing bacteria in babies, finds study

Western diet may increase the risk of ‘deadly sepsis’, warn experts

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