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High HDL levels block development of aneurysms in the aorta

New research provides early evidence that 'good' cholesterol may possess anti-aneurysm forming properties. In laboratory-based investigations, scientists found that increased levels of high-density lipoproteins (HDL), the so-called good cholesterol, blocked the development of aneurysms - dangerous 'ballooning' in the wall of a blood vessel - in the body's largest artery, the aorta.

7 Mar 2013

Researchers discover likely origin of epithelial ovarian cancer

Cornell University researchers have discovered a likely origin of epithelial ovarian cancer (ovarian carcinoma), the fifth leading cause of cancer death among women in the United States.

7 Mar 2013

CALHM1 protein controls sense of taste, finds study

In collaboration with other research institutions, a Feinstein Institute for Medical Research investigator discovered a new protein that controls the sense of taste. The findings are published in the March issue of Nature.

7 Mar 2013

Study combines induced pluripotent stem cell technology and genetic correction to treat DMD

Researchers at the University of Minnesota's Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD).

7 Mar 2013

Researchers discover how LRRK2 mutations in familial Parkinson's damage brain cells

Researchers at Columbia University Medical Center (CUMC), with collaborators at the Albert Einstein College of Medicine of Yeshiva University, have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells.

6 Mar 2013

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer.

6 Mar 2013

Targeting ARF6 may be effectively prevent melanoma metastasis to lungs

Researchers have identified a critical protein role in the metastasis of melanoma, the most serious form of skin cancer.

6 Mar 2013

Scientists discover key biochemical step underlying heart failure

Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step underlying the condition that could aid the development of new drugs to treat and possibly prevent it.

6 Mar 2013

European scientists find root cause of age-related dementia

A team of European scientists from the University Medical Center Hamburg-Eppendorf and the Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases at the University of Cologne in Germany has taken an important step closer to understanding the root cause of age-related dementia.

6 Mar 2013

Nordic EMBL Partnership for Molecular Medicine celebrates two important milestones

Today, the Nordic EMBL Partnership for Molecular Medicine celebrates two important milestones: the renewal of the partnership agreement for an extended period of 10 years, and the expansion of the Nordic EMBL network with the official opening of the Danish Research Institute of Translational Neuroscience (DANDRITE) at Aarhus University, which will become its Danish node.

6 Mar 2013

Study shows how high shear stress could cause VWF to change shape and form blood clots

New research from Rice University, Baylor College of Medicine (BCM) and the Puget Sound Blood Center (PSBC) has revealed how stresses of flow in the small blood vessels of the heart and brain could cause a common protein to change shape and form dangerous blood clots.

6 Mar 2013

Deleting Plin2 gene prevents obesity in mice

Researchers have discovered that deleting a specific gene in mice prevents them from becoming obese even on a high fat diet, a finding they believe may be replicated in humans.

6 Mar 2013

Insight into how protein synthesis and degradation help regulate delicate ballet of cell division

Biochemists at the University of Massachusetts Amherst including assistant professor Peter Chien recently gained new insight into how protein synthesis and degradation help to regulate the delicate ballet of cell division. In particular, they reveal how two proteins shelter each other in "mutually assured cleanup" to insure that division goes smoothly and safely.

5 Mar 2013

Gene cluster implicated in Behçet's disease

Scientists may have uncovered an underlying genetic susceptibility for Behçet's disease in East Asian patients.

5 Mar 2013

tRNA synthetases play unexpected and critical role in cancer metastasis

Studied for decades for their essential role in making proteins within cells, several amino acids known as tRNA synthetases were recently found to have an unexpected - and critical - additional role in cancer metastasis in a study conducted collaboratively in the labs of Karen Lounsbury, Ph.D., University of Vermont professor of pharmacology, and Christopher Francklyn, Ph.D., UVM professor of biochemistry.

5 Mar 2013

Sanofi, DBV Technologies partner to produce Viaskin's Active Pharmaceutical Ingredients

DBV Technologies, creator of Viaskin, a new standard in the treatment of allergies, announced today that it entered into a strategic manufacturing agreement with Sanofi to produce Viaskin's Active Pharmaceutical Ingredients (API), such as the peanut protein extract.

5 Mar 2013

Five scientists aim to make strides in predicting and preventing preterm birth

Five researchers from four states are investigating how genetics and infections interact to cause preterm birth as well as how proteins and hormones regulate a healthy pregnancy, all with the goal of giving more babies a healthy start in life, the March of Dimes announced today.

5 Mar 2013

Sanford-Burnham enters into partnership to test furin for treatment of dengue fever

Sanford-Burnham Medical Research Institute and 60- Pharmaceuticals, LLC, have entered into a partnership to test furin, a human proteinase, as a drug target for the treatment of dengue fever, one of the most common infectious diseases in the tropics and subtropics.

5 Mar 2013

Oxidative stress turns protein that protects healthy cells into executioner: Study

Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.

5 Mar 2013

Carbohydrate-rich diet during pregnancy may predict RSV severity in infants

An important predictor of the severity of respiratory syncytial virus (RSV) in infants may be what their mothers ate during pregnancy, according to a Vanderbilt study published in the American Journal of Respiratory and Critical Care Medicine.

5 Mar 2013

G Protein News and Research

High HDL levels block development of aneurysms in the aorta

Researchers discover likely origin of epithelial ovarian cancer

CALHM1 protein controls sense of taste, finds study

Study combines induced pluripotent stem cell technology and genetic correction to treat DMD

Researchers discover how LRRK2 mutations in familial Parkinson's damage brain cells

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

Targeting ARF6 may be effectively prevent melanoma metastasis to lungs

Scientists discover key biochemical step underlying heart failure

European scientists find root cause of age-related dementia

Nordic EMBL Partnership for Molecular Medicine celebrates two important milestones

Study shows how high shear stress could cause VWF to change shape and form blood clots

Deleting Plin2 gene prevents obesity in mice

Insight into how protein synthesis and degradation help regulate delicate ballet of cell division

Gene cluster implicated in Behçet's disease

tRNA synthetases play unexpected and critical role in cancer metastasis

Sanofi, DBV Technologies partner to produce Viaskin's Active Pharmaceutical Ingredients

Five scientists aim to make strides in predicting and preventing preterm birth

Sanford-Burnham enters into partnership to test furin for treatment of dengue fever

Oxidative stress turns protein that protects healthy cells into executioner: Study

Carbohydrate-rich diet during pregnancy may predict RSV severity in infants

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